FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2920005970> ?p ?o ?g. }

• W2920005970 endingPage "60" @default.
• W2920005970 startingPage "57" @default.
• W2920005970 abstract "Canine histiocytic sarcoma (HS) is an aggressive tumor type originating from dendritic cells or macrophages. We previously reported high incidence of the two-base (AT) insertion mutation (insAT) in the tumor protein p53 (TP53) gene in dogs with HS, and the aim of this study was to investigate the clinical significance of insAT in canine HS. The present study established a sensitive digital PCR-based assay for detecting insAT and examined its associations with clinical variables and survival time. The mutation was detected in 26 of 64 dogs (41%), and the mean mutant allele frequency was 1.9% (range, 0.014-35%), indicating that not all tumor cells harbor insAT. The incidence of insAT was significantly higher in dogs with metastatic lesions than in those without metastatic lesions. However, the existence of insAT was not associated with survival time or response to chemotherapy with lomustine or nimustine. This study suggested that HS cells might acquire insAT in the TP53 gene during development of metastasis, but insAT was not a prognostic factor in canine HS. Further studies are needed to investigate the contribution of insAT to the development of metastatic lesions of canine HS." @default.
• W2920005970 created "2019-03-11" @default.
• W2920005970 creator A5002863575 @default.
• W2920005970 creator A5004893002 @default.
• W2920005970 creator A5019110368 @default.
• W2920005970 creator A5029806948 @default.
• W2920005970 creator A5042603120 @default.
• W2920005970 creator A5054886646 @default.
• W2920005970 creator A5065111139 @default.
• W2920005970 creator A5073147177 @default.
• W2920005970 creator A5091203642 @default.
• W2920005970 date "2019-06-01" @default.
• W2920005970 modified "2023-10-16" @default.
• W2920005970 title "Clinical significance of the two-base insertion mutation in the TP53 gene in canine histiocytic sarcoma" @default.
• W2920005970 cites W1988125845 @default.
• W2920005970 cites W2014457499 @default.
• W2920005970 cites W2062789329 @default.
• W2920005970 cites W2096504879 @default.
• W2920005970 cites W2110444317 @default.
• W2920005970 cites W2195692730 @default.
• W2920005970 cites W2213268081 @default.
• W2920005970 cites W2282803984 @default.
• W2920005970 cites W2751691235 @default.
• W2920005970 cites W2802867685 @default.
• W2920005970 cites W4256390741 @default.
• W2920005970 doi "https://doi.org/10.1016/j.rvsc.2019.03.003" @default.
• W2920005970 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30852355" @default.
• W2920005970 hasPublicationYear "2019" @default.
• W2920005970 type Work @default.
• W2920005970 sameAs 2920005970 @default.
• W2920005970 citedByCount "1" @default.
• W2920005970 countsByYear W29200059702022 @default.
• W2920005970 crossrefType "journal-article" @default.
• W2920005970 hasAuthorship W2920005970A5002863575 @default.
• W2920005970 hasAuthorship W2920005970A5004893002 @default.
• W2920005970 hasAuthorship W2920005970A5019110368 @default.
• W2920005970 hasAuthorship W2920005970A5029806948 @default.
• W2920005970 hasAuthorship W2920005970A5042603120 @default.
• W2920005970 hasAuthorship W2920005970A5054886646 @default.
• W2920005970 hasAuthorship W2920005970A5065111139 @default.
• W2920005970 hasAuthorship W2920005970A5073147177 @default.
• W2920005970 hasAuthorship W2920005970A5091203642 @default.
• W2920005970 hasConcept C104317684 @default.
• W2920005970 hasConcept C120665830 @default.
• W2920005970 hasConcept C121332964 @default.
• W2920005970 hasConcept C121608353 @default.
• W2920005970 hasConcept C126322002 @default.
• W2920005970 hasConcept C142724271 @default.
• W2920005970 hasConcept C2776694085 @default.
• W2920005970 hasConcept C2776755627 @default.
• W2920005970 hasConcept C2777578932 @default.
• W2920005970 hasConcept C2778256501 @default.
• W2920005970 hasConcept C2779013556 @default.
• W2920005970 hasConcept C2779429289 @default.
• W2920005970 hasConcept C2779434656 @default.
• W2920005970 hasConcept C2994225774 @default.
• W2920005970 hasConcept C43100952 @default.
• W2920005970 hasConcept C501734568 @default.
• W2920005970 hasConcept C502942594 @default.
• W2920005970 hasConcept C54355233 @default.
• W2920005970 hasConcept C61511704 @default.
• W2920005970 hasConcept C63363279 @default.
• W2920005970 hasConcept C71924100 @default.
• W2920005970 hasConcept C86803240 @default.
• W2920005970 hasConceptScore W2920005970C104317684 @default.
• W2920005970 hasConceptScore W2920005970C120665830 @default.
• W2920005970 hasConceptScore W2920005970C121332964 @default.
• W2920005970 hasConceptScore W2920005970C121608353 @default.
• W2920005970 hasConceptScore W2920005970C126322002 @default.
• W2920005970 hasConceptScore W2920005970C142724271 @default.
• W2920005970 hasConceptScore W2920005970C2776694085 @default.
• W2920005970 hasConceptScore W2920005970C2776755627 @default.
• W2920005970 hasConceptScore W2920005970C2777578932 @default.
• W2920005970 hasConceptScore W2920005970C2778256501 @default.
• W2920005970 hasConceptScore W2920005970C2779013556 @default.
• W2920005970 hasConceptScore W2920005970C2779429289 @default.
• W2920005970 hasConceptScore W2920005970C2779434656 @default.
• W2920005970 hasConceptScore W2920005970C2994225774 @default.
• W2920005970 hasConceptScore W2920005970C43100952 @default.
• W2920005970 hasConceptScore W2920005970C501734568 @default.
• W2920005970 hasConceptScore W2920005970C502942594 @default.
• W2920005970 hasConceptScore W2920005970C54355233 @default.
• W2920005970 hasConceptScore W2920005970C61511704 @default.
• W2920005970 hasConceptScore W2920005970C63363279 @default.
• W2920005970 hasConceptScore W2920005970C71924100 @default.
• W2920005970 hasConceptScore W2920005970C86803240 @default.
• W2920005970 hasFunder F4320334764 @default.
• W2920005970 hasLocation W29200059701 @default.
• W2920005970 hasLocation W29200059702 @default.
• W2920005970 hasOpenAccess W2920005970 @default.
• W2920005970 hasPrimaryLocation W29200059701 @default.
• W2920005970 hasRelatedWork W2019043546 @default.
• W2920005970 hasRelatedWork W2074316965 @default.
• W2920005970 hasRelatedWork W2076351641 @default.
• W2920005970 hasRelatedWork W2115112186 @default.
• W2920005970 hasRelatedWork W2617912133 @default.
• W2920005970 hasRelatedWork W2888060900 @default.
• W2920005970 hasRelatedWork W2914186347 @default.

• next