Matches in SemOpenAlex for { <https://semopenalex.org/work/W2920012340> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2920012340 endingPage "193" @default.
- W2920012340 startingPage "187" @default.
- W2920012340 abstract "Prophylactic IV infusion of phenylephrine has been recommended to prevent hypotension during spinal anesthesia for cesarean delivery. However, the optimal infusion dose is unknown. This study aimed to determine the infusion dose of phenylephrine that would be effective in preventing hypotension in 50% (ED50) and 90% (ED90) of patients when administered as a prophylactic infusion at a fixed rate based on the individual body weight.Eighty parturients scheduled for elective cesarean delivery were randomly allocated to receive IV infusion of prophylactic phenylephrine at 0.25, 0.375, 0.5, or 0.625 µg/kg/min (n = 20 per group) started immediately after intrathecal injection of 10 mg hyperbaric bupivacaine and 5 µg sufentanil using a combined spinal-epidural technique. An effective dose was defined by the occurrence of no hypotension (defined as a decrease in systolic blood pressure by ≥20% below baseline and to <90 mm Hg) during the interval from the initiation of spinal anesthesia to delivery of the infant. Values for ED50 and ED90 of prophylactic phenylephrine were calculated using probit analysis.Hypotension occurred in 13/20, 8/20, 2/20, and 1/20 patients in the groups that received phenylephrine infusion at 0.25, 0.375, 0.5, or 0.625 µg/kg/min, respectively. The calculated values for ED50 and ED90 were 0.31 (95% CI, 0.24-0.36) and 0.54 (95% CI, 0.46-0.76) µg/kg/min, respectively. No difference was found in the incidence of adverse effects and neonatal outcomes among groups.Under the conditions of this study, when phenylephrine was given as a fixed-rate prophylactic infusion during spinal anesthesia for cesarean delivery to prevent hypotension, the values for ED50 and ED90 were 0.31 (95% CI, 0.24-0.36) and 0.54 (95% CI, 0.46-0.76) µg/kg/min, respectively." @default.
- W2920012340 created "2019-03-11" @default.
- W2920012340 creator A5005610930 @default.
- W2920012340 creator A5008312852 @default.
- W2920012340 creator A5008726478 @default.
- W2920012340 creator A5067488317 @default.
- W2920012340 creator A5081201991 @default.
- W2920012340 creator A5091423455 @default.
- W2920012340 date "2020-01-01" @default.
- W2920012340 modified "2023-09-30" @default.
- W2920012340 title "Dose–Response Study of 4 Weight-Based Phenylephrine Infusion Regimens for Preventing Hypotension During Cesarean Delivery Under Combined Spinal–Epidural Anesthesia" @default.
- W2920012340 cites W1950129318 @default.
- W2920012340 cites W2017278007 @default.
- W2920012340 cites W2024642539 @default.
- W2920012340 cites W2026654655 @default.
- W2920012340 cites W2028067695 @default.
- W2920012340 cites W2051287378 @default.
- W2920012340 cites W2052907879 @default.
- W2920012340 cites W2053829705 @default.
- W2920012340 cites W2148335841 @default.
- W2920012340 cites W2331117443 @default.
- W2920012340 cites W2331960282 @default.
- W2920012340 cites W2591823270 @default.
- W2920012340 cites W2593302516 @default.
- W2920012340 cites W2594708050 @default.
- W2920012340 cites W2765374518 @default.
- W2920012340 cites W2771633375 @default.
- W2920012340 cites W2772112079 @default.
- W2920012340 cites W2789883258 @default.
- W2920012340 cites W4252051413 @default.
- W2920012340 doi "https://doi.org/10.1213/ane.0000000000004092" @default.
- W2920012340 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30829668" @default.
- W2920012340 hasPublicationYear "2020" @default.
- W2920012340 type Work @default.
- W2920012340 sameAs 2920012340 @default.
- W2920012340 citedByCount "14" @default.
- W2920012340 countsByYear W29200123402020 @default.
- W2920012340 countsByYear W29200123402021 @default.
- W2920012340 countsByYear W29200123402022 @default.
- W2920012340 countsByYear W29200123402023 @default.
- W2920012340 crossrefType "journal-article" @default.
- W2920012340 hasAuthorship W2920012340A5005610930 @default.
- W2920012340 hasAuthorship W2920012340A5008312852 @default.
- W2920012340 hasAuthorship W2920012340A5008726478 @default.
- W2920012340 hasAuthorship W2920012340A5067488317 @default.
- W2920012340 hasAuthorship W2920012340A5081201991 @default.
- W2920012340 hasAuthorship W2920012340A5091423455 @default.
- W2920012340 hasBestOaLocation W29200123401 @default.
- W2920012340 hasConcept C126322002 @default.
- W2920012340 hasConcept C170493617 @default.
- W2920012340 hasConcept C197934379 @default.
- W2920012340 hasConcept C2777019824 @default.
- W2920012340 hasConcept C2777952589 @default.
- W2920012340 hasConcept C2779234561 @default.
- W2920012340 hasConcept C3020128735 @default.
- W2920012340 hasConcept C42219234 @default.
- W2920012340 hasConcept C42533223 @default.
- W2920012340 hasConcept C54355233 @default.
- W2920012340 hasConcept C71924100 @default.
- W2920012340 hasConcept C84393581 @default.
- W2920012340 hasConcept C86803240 @default.
- W2920012340 hasConcept C98274493 @default.
- W2920012340 hasConceptScore W2920012340C126322002 @default.
- W2920012340 hasConceptScore W2920012340C170493617 @default.
- W2920012340 hasConceptScore W2920012340C197934379 @default.
- W2920012340 hasConceptScore W2920012340C2777019824 @default.
- W2920012340 hasConceptScore W2920012340C2777952589 @default.
- W2920012340 hasConceptScore W2920012340C2779234561 @default.
- W2920012340 hasConceptScore W2920012340C3020128735 @default.
- W2920012340 hasConceptScore W2920012340C42219234 @default.
- W2920012340 hasConceptScore W2920012340C42533223 @default.
- W2920012340 hasConceptScore W2920012340C54355233 @default.
- W2920012340 hasConceptScore W2920012340C71924100 @default.
- W2920012340 hasConceptScore W2920012340C84393581 @default.
- W2920012340 hasConceptScore W2920012340C86803240 @default.
- W2920012340 hasConceptScore W2920012340C98274493 @default.
- W2920012340 hasIssue "1" @default.
- W2920012340 hasLocation W29200123401 @default.
- W2920012340 hasLocation W29200123402 @default.
- W2920012340 hasLocation W29200123403 @default.
- W2920012340 hasOpenAccess W2920012340 @default.
- W2920012340 hasPrimaryLocation W29200123401 @default.
- W2920012340 hasRelatedWork W1976567472 @default.
- W2920012340 hasRelatedWork W1984841713 @default.
- W2920012340 hasRelatedWork W2007316116 @default.
- W2920012340 hasRelatedWork W2024642539 @default.
- W2920012340 hasRelatedWork W2048090345 @default.
- W2920012340 hasRelatedWork W2354958659 @default.
- W2920012340 hasRelatedWork W2593668220 @default.
- W2920012340 hasRelatedWork W2901520753 @default.
- W2920012340 hasRelatedWork W2920012340 @default.
- W2920012340 hasRelatedWork W3029449902 @default.
- W2920012340 hasVolume "130" @default.
- W2920012340 isParatext "false" @default.
- W2920012340 isRetracted "false" @default.
- W2920012340 magId "2920012340" @default.
- W2920012340 workType "article" @default.