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- W2920082801 abstract "In their cross-sectional study of 5177 children admitted to 28 emergency departments across Europe between Nov 1, 2014, and Feb 28, 2016, Josephine van de Maat and colleagues 1 van de Maat J van de Voort E Mintegi S et al. Antibiotic prescription for febrile children in European emergency departments: a cross-sectional, observational study. Lancet Inf Dis. 2019; (published online Feb 28.)http://dx.doi.org/10.1016/S1473-3099(18)30672-8 Summary Full Text Full Text PDF PubMed Scopus (27) Google Scholar report in The Lancet Infectious Diseases that 1454 (32%) of 4560 children without comorbidities were given a course of antibiotics on discharge. The variation in prescription frequency across countries was vast, from 19% (81 of 428 children received antibiotics) in Switzerland to 64% (450 of 708) in Turkey. The authors focused their analysis on respiratory tract infections, which accounted for 82% of all antibiotic prescriptions, to identify factors affecting prescription decisions. Duration of fever, elevated C-reactive protein concentration, focal abnormalities, or, to a lesser degree, diffuse abnormalities in chest X-rays were associated with increased prescribing but these factors did not fully explain the variance in the model. The authors hypothesised that other factors they did not include might be contributing. However, the high frequency of prescriptions also raises the issue of irrationality toward prescribing antibiotics. Antibiotic prescription for febrile children in European emergency departments: a cross-sectional, observational studyAntibiotic prescription in European emergency departments is highly variable, with frequent use of second-line antibiotics. To ensure successful antibiotic stewardship initiatives in Europe aimed at reducing unnecessary prescription of antibiotics, variability of prescription across hospitals should be considered, drivers of suboptimal antibiotic prescription at the local level need to be identified, and European guidelines need to be devised. Full-Text PDF" @default.
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- W2920082801 date "2019-04-01" @default.
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- W2920082801 title "Antibiotic prescription in paediatric emergency departments: fear and reason" @default.
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- W2920082801 doi "https://doi.org/10.1016/s1473-3099(18)30727-8" @default.
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