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- W2920119086 abstract "Knee osteoarthritis (OA) is a common type of musculoskeletal disability, particularly among the elderly population. Excessive contact forces on the joint, or on specific parts of it (e.g. medial compartment), or shifting the contact forces to the regions that are not adapted to loading are the mechanical factors which can trigger OA. Therefore, it is crucial to understand the differences of these mechanical parameters in OA subjects with respect to the healthy ones. The aim of this study was to the compare the tibiofemoral contact point locations and the contact forces in OA and healthy subjects and examine if the contact point locations influence the contact force sharing in both groups.The tibiofemoral contact point locations in 10 healthy and 9 osteoarthritic (OA) subjects during a weight-bearing squat was measured using stand-alone biplane X-ray images. A manual multiple view 3D reconstruction/registration method was used to reconstruct the bones in different squat postures from the biplane radiographs and a weighted center of bone-to-bone proximity was applied to estimate the contact point locations. Results showed that the contact point locations of the OA subjects on the medial and lateral compartments were shifted medially compared to the healthy group. In both groups, contact points showed a posterior excursion on the medial compartment and posterior and lateral excursions on the lateral compartment, where the excursion on the lateral compartment was smaller in OA subjects.To estimate the tibiofemoral contact forces, a custom musculoskeletal model of the lower limb with the integration of personalized contact points was provided to estimate contact forces at subject-specific contact points during gait. The tibiofemoral joint model was reformulated so that the constraints of the joint were formed by the superimposition of the personalized tibial and femoral contact points. The suggested constraints are adaptable to the contact points derived from the classical joint models or those experimentally measured from the 3D imaging techniques. The estimated contact forces estimated using the personalized contact points were compared to those estimated from the classical knee joint models in 10 healthy subjects. Results showed that the impact of personalization of contact points on the contact forces is very variable among the subjects and the shifts of the contact points alone cannot predict the distribution of contact forces in the medial and lateral compartments.To evaluate the contribution of contact point locations to the contact force distribution the musculoskeletal model of the lower limb with the personalized contact point trajectories were used to estimate the medial and lateral contact forces of 10 healthy and 12 OA subjects. The contact forces in healthy subjects were slightly higher compared to the OA subjects. However, no statistically significant difference was noted in the peaks of medial, lateral or total contact forces. The regression analysis results showed that the knee adduction moment and knee flexion moment were the main contributors to the medial-to-total contact force ratio (MR) in both groups. From the components of the contact point location, the medial contact point location in medial/lateral direction had a significant contribution to the MR in OA subjects. This study showed that the mechanism of load distribution was different in OA joints where contrary to the healthy ones the contact point location was a significant contributor to MR. In addition, the knee flexion moment had a higher contribution to MR than the knee adduction moment whereas in healthy subjects the knee adduction moment was the most significant contributor to the MR." @default.
- W2920119086 created "2019-03-11" @default.
- W2920119086 creator A5015859388 @default.
- W2920119086 date "2018-06-27" @default.
- W2920119086 modified "2023-09-24" @default.
- W2920119086 title "Tibiofemoral contact areas and contact forces in healthy and osteoarthritic subjects" @default.
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