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- W2920140422 endingPage "591" @default.
- W2920140422 startingPage "574" @default.
- W2920140422 abstract "Primary biliary cholangitis/cirrhosis (PBC) is a rare autoimmune liver disease for which therapies are limited to the licensed agents ursodeoxycholic acid (UDCA) and obeticholic acid (OCA). The low prevalence of PBC represents a significant barrier to conducting large controlled clinical outcome trials. Fibric acid derivatives exert potent anti-cholestatic effects through the variable activation of peroxisome proliferator-activated receptors (PPAR), in addition to downregulation of several pathways leading to bile acid synthesis. In patients with PBC exhibiting florid interface hepatitis on biopsy, there are anecdotal data demonstrating the efficacy of budesonide in improving liver histology and biochemistry when used in combination with UDCA. Azathioprine has very little effect in improving serum liver biochemistry or hepatic histology in PBC and although early trials suggested a tendency toward improved survival, this failed to reach statistical significance." @default.
- W2920140422 created "2019-03-11" @default.
- W2920140422 creator A5028517177 @default.
- W2920140422 creator A5065028057 @default.
- W2920140422 date "2019-02-27" @default.
- W2920140422 modified "2023-10-14" @default.
- W2920140422 title "Primary Biliary Cholangitis (Formerly Primary Biliary Cirrhosis)" @default.
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