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• W2920146477 abstract "In the last two decades, there has been a considerable rise in the number of renal masses incidentally detected. Although the majority of these masses have distinct clinical and radiological features, a minority share similar patterns leading to diagnostic uncertainty. A clear understating of the evaluation, current management approaches, and awareness of the evolving evidence pertaining to renal masses is essential. With improvement in imaging modalities and pathological assessment techniques, a more precise diagnosis can be made. In the last few years, we have observed a significant evolution in surgical techniques with various minimally invasive approaches showing promising outcomes. The understanding of the molecular basis of many of these lesions is paramount. Translational research has led to the introduction of various novel targeted therapies in an attempt to improve oncological outcomes. Upper urinary tract (UUT) tumours are uncommon cancers of the renal pelvis, calyces, and ureter. Upper urinary tract urothelial (transitional) cell carcinomas (UT-UCC) are notoriously aggressive cancers with a propensity for local recurrence and advancement to higher-stage disease. Additionally, they have a tendency for synchronicity and metachronicity. They bear histological resemblance to bladder urothelial cancer. Accurate diagnosis and staging is reliant on a combination of cytology, endoscopic, and UUT imaging modalities. The treatment of UT-UCC depends on the stage, grade, and volume of the disease. Radical nephroureterectomy (RNU) with ipsilateral cuff excision is the most oncological efficacious treatment option for localised UT-UCC. Other treatment options for UT-UCC include ureteroscopic and percutaneous ablation and segmental resection. The role of adjuvant treatment and systemic chemotherapy remain unclear and continue to be under the realms of future research." @default.
• W2920146477 created "2019-03-11" @default.
• W2920146477 creator A5000680967 @default.
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• W2920146477 date "2019-02-27" @default.
• W2920146477 modified "2023-10-18" @default.
• W2920146477 title "Kidney and Ureter Neoplasm" @default.
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