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- W2920163856 abstract "Abstract Basement membranes (BMs) are cell-associated extracellular matrices that support tissue integrity, signaling, and barrier properties. Type IV collagen is critical for BM mechanical and signaling functions, yet how it is directed into BMs in vivo is unclear. Through live-cell imaging of endogenous localization, conditional knockdown, and misexpression experiments, we uncovered distinct mechanisms of integrin-mediated collagen recruitment to Caenorhabditis elegans gonadal and pharyngeal BMs. The putative laminin-binding αINA-1/βPAT-3 integrin was selectively activated in the gonad and recruited laminin, which directed moderate collagen incorporation. In contrast, the putative Arg-Gly-Asp (RGD)-binding αPAT-2/βPAT-3 integrin was activated in the pharynx and recruited high levels of collagen independent of laminin. Through an RNAi screen, we further identified the small GTPase RAP-3 (Rap1) as a pharyngeal-specific PAT-2/PAT-3 activator that modulates collagen levels. Together, these studies demonstrate that tissues can use distinct mechanisms to direct collagen incorporation into BMs to precisely control collagen levels and construct diverse BMs." @default.
- W2920163856 created "2019-03-11" @default.
- W2920163856 creator A5014466674 @default.
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- W2920163856 creator A5066889503 @default.
- W2920163856 creator A5067307252 @default.
- W2920163856 date "2019-03-05" @default.
- W2920163856 modified "2023-09-28" @default.
- W2920163856 title "α-integrins dictate distinct modes of type IV collagen recruitment to basement membranes" @default.
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- W2920163856 doi "https://doi.org/10.1101/568964" @default.
- W2920163856 hasPublicationYear "2019" @default.
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