Matches in SemOpenAlex for { <https://semopenalex.org/work/W2920180968> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2920180968 abstract "Background: Impaired kidney function is frequently observed in heart surgery patients following cardio-pulmonary bypass. Previous studies by our group have linked acute reductions in nitric oxide bioactivity, specifically declines in the main regulator of tissue blood flow S-nitrosohemoglobin (SNO-Hb), to reductions in kidney oxygenation and blood flow and subsequent renal impairment. For the current study, we hypothesized that components of the bypass procedure (viz. transfusion and red blood cell trauma) would reduce circulating SNO-Hb levels with the magnitude of this reduction correlating with markers of kidney function and patient outcome. Methods: After obtaining written informed consent, blood samples were obtained before and during bypass and on post-operative day (POD) 1. In addition to quantifying SNO-Hb samples were analyzed for change in kidney function (estimated glomerular filtration rate; eGFR), and plasma erythropoietin (EPO) concentration. Status and outcome data were secured from the patients’ medical record. Results: In the patients studied to date (n=30), there was a significant decline in SNO-Hb concentration by POD 1, the level of which inversely correlated with ICU stay (R=-0.32). In addition, there was a direct correlation between SNO-Hb and eGFR on PODs 1 & 2 (R=0.48 and 0.30, respectively), i.e. lower SNO-Hb tracked with reductions in kidney function. Consistent with a presumed reduction in kidney oxygenation, we observed a significant rise in plasma EPO levels when coming off pump that were sustained into POD 1. Furthermore, the rise in EPO was inversely correlated with both SNO-Hb (R=-0.53) and eGFR (R=-0.55). Conclusion: CPB decreases SNO-Hb and is associated with kidney dysfunction and worse patient outcome (e.g. increased ICU stay). While the mechanism for this decline remains to be determined, the results suggest that therapies directed at maintaining or increasing NO bioactivity could improve outcome in adult cardiac surgery patients." @default.
- W2920180968 created "2019-03-11" @default.
- W2920180968 creator A5005168094 @default.
- W2920180968 creator A5024244993 @default.
- W2920180968 creator A5029240851 @default.
- W2920180968 creator A5041685878 @default.
- W2920180968 creator A5050716059 @default.
- W2920180968 creator A5070833857 @default.
- W2920180968 date "2018-08-03" @default.
- W2920180968 modified "2023-09-27" @default.
- W2920180968 title "Abstract 365: Potential Relationship Between Nitric Oxide Bioactivity And Kidney Function Following Cardio-pulmonary Bypass" @default.
- W2920180968 doi "https://doi.org/10.1161/res.123.suppl_1.365" @default.
- W2920180968 hasPublicationYear "2018" @default.
- W2920180968 type Work @default.
- W2920180968 sameAs 2920180968 @default.
- W2920180968 citedByCount "0" @default.
- W2920180968 crossrefType "journal-article" @default.
- W2920180968 hasAuthorship W2920180968A5005168094 @default.
- W2920180968 hasAuthorship W2920180968A5024244993 @default.
- W2920180968 hasAuthorship W2920180968A5029240851 @default.
- W2920180968 hasAuthorship W2920180968A5041685878 @default.
- W2920180968 hasAuthorship W2920180968A5050716059 @default.
- W2920180968 hasAuthorship W2920180968A5070833857 @default.
- W2920180968 hasConcept C126322002 @default.
- W2920180968 hasConcept C126894567 @default.
- W2920180968 hasConcept C134018914 @default.
- W2920180968 hasConcept C142225936 @default.
- W2920180968 hasConcept C159641895 @default.
- W2920180968 hasConcept C164705383 @default.
- W2920180968 hasConcept C2778534260 @default.
- W2920180968 hasConcept C2778653478 @default.
- W2920180968 hasConcept C2780091579 @default.
- W2920180968 hasConcept C2780472472 @default.
- W2920180968 hasConcept C519581460 @default.
- W2920180968 hasConcept C70289976 @default.
- W2920180968 hasConcept C71924100 @default.
- W2920180968 hasConceptScore W2920180968C126322002 @default.
- W2920180968 hasConceptScore W2920180968C126894567 @default.
- W2920180968 hasConceptScore W2920180968C134018914 @default.
- W2920180968 hasConceptScore W2920180968C142225936 @default.
- W2920180968 hasConceptScore W2920180968C159641895 @default.
- W2920180968 hasConceptScore W2920180968C164705383 @default.
- W2920180968 hasConceptScore W2920180968C2778534260 @default.
- W2920180968 hasConceptScore W2920180968C2778653478 @default.
- W2920180968 hasConceptScore W2920180968C2780091579 @default.
- W2920180968 hasConceptScore W2920180968C2780472472 @default.
- W2920180968 hasConceptScore W2920180968C519581460 @default.
- W2920180968 hasConceptScore W2920180968C70289976 @default.
- W2920180968 hasConceptScore W2920180968C71924100 @default.
- W2920180968 hasIssue "Suppl_1" @default.
- W2920180968 hasLocation W29201809681 @default.
- W2920180968 hasOpenAccess W2920180968 @default.
- W2920180968 hasPrimaryLocation W29201809681 @default.
- W2920180968 hasRelatedWork W1977762863 @default.
- W2920180968 hasRelatedWork W2010123253 @default.
- W2920180968 hasRelatedWork W2054438741 @default.
- W2920180968 hasRelatedWork W2279888091 @default.
- W2920180968 hasRelatedWork W2404152533 @default.
- W2920180968 hasRelatedWork W2418654739 @default.
- W2920180968 hasRelatedWork W2920180968 @default.
- W2920180968 hasRelatedWork W2966250918 @default.
- W2920180968 hasRelatedWork W3003790982 @default.
- W2920180968 hasRelatedWork W4229030241 @default.
- W2920180968 hasVolume "123" @default.
- W2920180968 isParatext "false" @default.
- W2920180968 isRetracted "false" @default.
- W2920180968 magId "2920180968" @default.
- W2920180968 workType "article" @default.