FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2920193420> ?p ?o ?g. }

• W2920193420 abstract "Abstract Introduction Evidence suggests the existence of cytokine disturbances in patients with schizophrenia but their association with psychopathology is still unclear. The aim of the current study was to determine if pro-inflammatory cytokine levels (tumor necrosis factor-α, interleukin (IL)-6, IL-2, IL-1β, IL-1RA) are increased in stable outpatients compared with healthy subjects, and to analyze if they could be specific biomarkers of clinical dimensions in schizophrenia. Methods We studied 73 stable outpatients with schizophrenia in their first 10 years of illness and 73 age- and sex-matched healthy controls. An accurate assessment of clinical dimensions (positive, negative, depressive, cognitive) was performed in patients. Results Only IL-6 levels were significantly increased in patients after controlling for body mass index, waist circumference, smoking, and psychopharmacological treatment, compared with healthy subjects. After adjusting for several confounders, multiple linear regression models identified that Positive and Negative Syndrome Scale negative symptoms, general psychopathology, and global severity are predicted by IL-1β concentrations, while motivation and pleasure domain of Clinical Assessment Interview for Negative Symptoms and Personal and Social Performance global functioning scores are predicted by IL-2 levels. Cognitive performance, positive, and depressive symptom severity did not correlate with any cytokine. Conclusions Our findings suggested that IL-6 concentrations are elevated in stable patients with schizophrenia. Whereas IL-2 specifically marks severity of the motivation and pleasure domain of negative symptoms, IL-1β is not specific to this dimension as it also predicts severity of general and global symptomatology." @default.
• W2920193420 created "2019-03-11" @default.
• W2920193420 creator A5003997662 @default.
• W2920193420 creator A5021850889 @default.
• W2920193420 creator A5027378045 @default.
• W2920193420 creator A5038482944 @default.
• W2920193420 creator A5043060628 @default.
• W2920193420 creator A5064815642 @default.
• W2920193420 creator A5073194403 @default.
• W2920193420 creator A5084393887 @default.
• W2920193420 creator A5084687443 @default.
• W2920193420 date "2019-01-01" @default.
• W2920193420 modified "2023-10-11" @default.
• W2920193420 title "Can interleukin-2 and interleukin-1β be specific biomarkers of negative symptoms in schizophrenia?" @default.
• W2920193420 cites W1550926313 @default.
• W2920193420 cites W1608349302 @default.
• W2920193420 cites W1831393147 @default.
• W2920193420 cites W1969833165 @default.
• W2920193420 cites W1971002170 @default.
• W2920193420 cites W1979283977 @default.
• W2920193420 cites W1988895293 @default.
• W2920193420 cites W1993026721 @default.
• W2920193420 cites W2000422174 @default.
• W2920193420 cites W2002024279 @default.
• W2920193420 cites W2012832829 @default.
• W2920193420 cites W2015656459 @default.
• W2920193420 cites W2030396834 @default.
• W2920193420 cites W2032806073 @default.
• W2920193420 cites W2042755650 @default.
• W2920193420 cites W2048363612 @default.
• W2920193420 cites W2070023870 @default.
• W2920193420 cites W2070757253 @default.
• W2920193420 cites W2079187454 @default.
• W2920193420 cites W2094336141 @default.
• W2920193420 cites W2121637331 @default.
• W2920193420 cites W2122501311 @default.
• W2920193420 cites W2138022406 @default.
• W2920193420 cites W2139161910 @default.
• W2920193420 cites W2152502983 @default.
• W2920193420 cites W2165988750 @default.
• W2920193420 cites W2166043067 @default.
• W2920193420 cites W2166818025 @default.
• W2920193420 cites W2167486251 @default.
• W2920193420 cites W2168408561 @default.
• W2920193420 cites W2175366611 @default.
• W2920193420 cites W2210219816 @default.
• W2920193420 cites W2276233600 @default.
• W2920193420 cites W2302122367 @default.
• W2920193420 cites W2399060753 @default.
• W2920193420 cites W2439898622 @default.
• W2920193420 cites W2547285684 @default.
• W2920193420 cites W2576331479 @default.
• W2920193420 cites W2592490726 @default.
• W2920193420 cites W2605908960 @default.
• W2920193420 cites W2621566730 @default.
• W2920193420 cites W2745345494 @default.
• W2920193420 cites W2766428619 @default.
• W2920193420 doi "https://doi.org/10.1016/j.rpsmen.2018.03.003" @default.
• W2920193420 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29724678" @default.
• W2920193420 hasPublicationYear "2019" @default.
• W2920193420 type Work @default.
• W2920193420 sameAs 2920193420 @default.
• W2920193420 citedByCount "2" @default.
• W2920193420 countsByYear W29201934202023 @default.
• W2920193420 crossrefType "journal-article" @default.
• W2920193420 hasAuthorship W2920193420A5003997662 @default.
• W2920193420 hasAuthorship W2920193420A5021850889 @default.
• W2920193420 hasAuthorship W2920193420A5027378045 @default.
• W2920193420 hasAuthorship W2920193420A5038482944 @default.
• W2920193420 hasAuthorship W2920193420A5043060628 @default.
• W2920193420 hasAuthorship W2920193420A5064815642 @default.
• W2920193420 hasAuthorship W2920193420A5073194403 @default.
• W2920193420 hasAuthorship W2920193420A5084393887 @default.
• W2920193420 hasAuthorship W2920193420A5084687443 @default.
• W2920193420 hasConcept C118552586 @default.
• W2920193420 hasConcept C123273963 @default.
• W2920193420 hasConcept C126322002 @default.
• W2920193420 hasConcept C15744967 @default.
• W2920193420 hasConcept C169900460 @default.
• W2920193420 hasConcept C185592680 @default.
• W2920193420 hasConcept C2776412080 @default.
• W2920193420 hasConcept C2778690821 @default.
• W2920193420 hasConcept C2779727114 @default.
• W2920193420 hasConcept C2780135775 @default.
• W2920193420 hasConcept C2780221984 @default.
• W2920193420 hasConcept C2781197716 @default.
• W2920193420 hasConcept C55493867 @default.
• W2920193420 hasConcept C70410870 @default.
• W2920193420 hasConcept C71924100 @default.
• W2920193420 hasConcept C74172505 @default.
• W2920193420 hasConcept C77350462 @default.
• W2920193420 hasConceptScore W2920193420C118552586 @default.
• W2920193420 hasConceptScore W2920193420C123273963 @default.
• W2920193420 hasConceptScore W2920193420C126322002 @default.
• W2920193420 hasConceptScore W2920193420C15744967 @default.
• W2920193420 hasConceptScore W2920193420C169900460 @default.
• W2920193420 hasConceptScore W2920193420C185592680 @default.
• W2920193420 hasConceptScore W2920193420C2776412080 @default.
• W2920193420 hasConceptScore W2920193420C2778690821 @default.
• W2920193420 hasConceptScore W2920193420C2779727114 @default.

• next