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• W2920209417 endingPage "188" @default.
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• W2920209417 abstract "Bisphenol A (BPA) is an environmentally ubiquitous chemical widely used in industry and is known to have adverse effects on organisms. Given the negative effect, BPA-free products have been developed with BPA analogs such as bisphenol F (BPF) and bisphenol S (BPS); however, these analogs are proving to exhibit toxicity similar to that of BPA. In the present study, we aimed to identify and compare the underlying mechanisms of toxicity of BPA, BPF, and BPS at the transcriptional level by conducting global transcriptome sequencing (RNA-Seq) on zebrafish embryos. RNA-seq results showed that the expression levels of 285, 191, and 246 genes were significantly changed in zebrafish larvae after embryos were treated for 120 h with 100 μg/L BPA, BPF, and BPS, respectively. Among the genes exhibiting altered expression, a substantial number were common to two or three exposure groups, suggesting consistent toxicity between the three bisphenols. We further validated the expression levels of 19 differentially expressed genes by qRT-PCR, using sequencing RNA and the RNA samples after treatment by 0.01, 1, and 100 μg/L bisphenols under identical condition, the results were similar to RNA-Seq. Moreover, functional enrichment analysis indicated that metabolism was the main pathway which disrupted in zebrafish larvae by bisphenols treatment. Protein-protein interaction network analysis indicated that six DEGs (ces, cda, dpyd, upp1, upp2, and cmpk2) interact together in the drug metabolism of zebrafish. In summary, our study revealed changes in the transcription of genes upon bisphenols treatment in zebrafish larvae for the first time, indicating that BPF and BPS may cause adverse effects similar to BPA via their involvement in various biological processes, providing a solid foundation for further research on the toxicology of BPA analogs." @default.
• W2920209417 created "2019-03-11" @default.
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• W2920209417 date "2019-06-01" @default.
• W2920209417 modified "2023-10-16" @default.
• W2920209417 title "Metabolism disruption analysis of zebrafish larvae in response to BPA and BPA analogs based on RNA-Seq technique" @default.
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• W2920209417 cites W1866198391 @default.
• W2920209417 cites W1972086601 @default.
• W2920209417 cites W1976182007 @default.
• W2920209417 cites W1987797208 @default.
• W2920209417 cites W1987800568 @default.
• W2920209417 cites W1990053219 @default.
• W2920209417 cites W1994219871 @default.
• W2920209417 cites W2009039250 @default.
• W2920209417 cites W2013210063 @default.
• W2920209417 cites W2014089999 @default.
• W2920209417 cites W2027847170 @default.
• W2920209417 cites W2030873172 @default.
• W2920209417 cites W2048655519 @default.
• W2920209417 cites W2053578993 @default.
• W2920209417 cites W2064258700 @default.
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• W2920209417 cites W2133461377 @default.
• W2920209417 cites W2133790733 @default.
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• W2920209417 cites W2141458291 @default.
• W2920209417 cites W2142237411 @default.
• W2920209417 cites W2143248519 @default.
• W2920209417 cites W2145876138 @default.
• W2920209417 cites W2147526198 @default.
• W2920209417 cites W2153032620 @default.
• W2920209417 cites W2154139219 @default.
• W2920209417 cites W2158714788 @default.
• W2920209417 cites W2159140746 @default.
• W2920209417 cites W2159317013 @default.
• W2920209417 cites W2168755677 @default.
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• W2920209417 doi "https://doi.org/10.1016/j.ecoenv.2019.01.126" @default.
• W2920209417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30826544" @default.
• W2920209417 hasPublicationYear "2019" @default.
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