Matches in SemOpenAlex for { <https://semopenalex.org/work/W2920220762> ?p ?o ?g. }
- W2920220762 endingPage "575.e5" @default.
- W2920220762 startingPage "567" @default.
- W2920220762 abstract "Long-term delivery of anti-HIV monoclonal antibodies (mAbs) using adeno-associated virus (AAV) vectors holds promise for the prevention and treatment of HIV infection. We describe a therapy trial in which four rhesus monkeys were infected with SHIV-AD8 for 86 weeks before receiving the AAV-encoded mAbs 3BNC117, 10-1074, and 10E8. Although anti-drug antibody (ADA) responses restricted mAb delivery, one monkey successfully maintained 50–150 μg/mL of 3BNC117 and 10-1074 for over 2 years. Delivery of these two mAbs to this monkey resulted in an abrupt decline in plasma viremia, which remained undetectable for 38 successive measurements over 3 years. We generated two more examples of virologic suppression using AAV delivery of a cocktail of four mAbs in a 12-monkey study. Our results provide proof of concept for AAV-delivered mAbs to produce a “functional cure.” However, they also serve as a warning that ADAs may be a problem for practical application of this approach in humans." @default.
- W2920220762 created "2019-03-11" @default.
- W2920220762 creator A5002345157 @default.
- W2920220762 creator A5004282576 @default.
- W2920220762 creator A5009470292 @default.
- W2920220762 creator A5043225490 @default.
- W2920220762 creator A5056797877 @default.
- W2920220762 creator A5058855999 @default.
- W2920220762 creator A5069303302 @default.
- W2920220762 creator A5072715696 @default.
- W2920220762 creator A5082767203 @default.
- W2920220762 creator A5083004103 @default.
- W2920220762 date "2019-03-01" @default.
- W2920220762 modified "2023-10-01" @default.
- W2920220762 title "Adeno-Associated Virus Delivery of Anti-HIV Monoclonal Antibodies Can Drive Long-Term Virologic Suppression" @default.
- W2920220762 cites W1062587256 @default.
- W2920220762 cites W1518023932 @default.
- W2920220762 cites W1519797983 @default.
- W2920220762 cites W1565933769 @default.
- W2920220762 cites W1823082370 @default.
- W2920220762 cites W1896824500 @default.
- W2920220762 cites W1919421000 @default.
- W2920220762 cites W1974431423 @default.
- W2920220762 cites W1979162895 @default.
- W2920220762 cites W1992628263 @default.
- W2920220762 cites W1993634191 @default.
- W2920220762 cites W1998683102 @default.
- W2920220762 cites W2000070017 @default.
- W2920220762 cites W2007021820 @default.
- W2920220762 cites W2022039028 @default.
- W2920220762 cites W2025632994 @default.
- W2920220762 cites W2028518212 @default.
- W2920220762 cites W2032515169 @default.
- W2920220762 cites W2035813371 @default.
- W2920220762 cites W2038244683 @default.
- W2920220762 cites W2054677438 @default.
- W2920220762 cites W2065202529 @default.
- W2920220762 cites W2065379504 @default.
- W2920220762 cites W2065904018 @default.
- W2920220762 cites W2070086938 @default.
- W2920220762 cites W2073383703 @default.
- W2920220762 cites W2087468350 @default.
- W2920220762 cites W2088344513 @default.
- W2920220762 cites W2092188479 @default.
- W2920220762 cites W2094826813 @default.
- W2920220762 cites W2109368056 @default.
- W2920220762 cites W2113236498 @default.
- W2920220762 cites W2118274231 @default.
- W2920220762 cites W2124058652 @default.
- W2920220762 cites W2132694357 @default.
- W2920220762 cites W2137280949 @default.
- W2920220762 cites W2147169218 @default.
- W2920220762 cites W2150633245 @default.
- W2920220762 cites W2159515958 @default.
- W2920220762 cites W2164250779 @default.
- W2920220762 cites W2168915939 @default.
- W2920220762 cites W2190652005 @default.
- W2920220762 cites W2237428848 @default.
- W2920220762 cites W2264232485 @default.
- W2920220762 cites W2272185077 @default.
- W2920220762 cites W2308542537 @default.
- W2920220762 cites W2381153372 @default.
- W2920220762 cites W2415277045 @default.
- W2920220762 cites W2468791964 @default.
- W2920220762 cites W2473595575 @default.
- W2920220762 cites W2547359354 @default.
- W2920220762 cites W2550082644 @default.
- W2920220762 cites W2551273870 @default.
- W2920220762 cites W2557191642 @default.
- W2920220762 cites W2572760626 @default.
- W2920220762 cites W2598871150 @default.
- W2920220762 cites W2599802686 @default.
- W2920220762 cites W2802584574 @default.
- W2920220762 cites W2890205877 @default.
- W2920220762 cites W2892753696 @default.
- W2920220762 cites W2895775323 @default.
- W2920220762 cites W2897595682 @default.
- W2920220762 doi "https://doi.org/10.1016/j.immuni.2019.02.005" @default.
- W2920220762 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6457122" @default.
- W2920220762 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30850342" @default.
- W2920220762 hasPublicationYear "2019" @default.
- W2920220762 type Work @default.
- W2920220762 sameAs 2920220762 @default.
- W2920220762 citedByCount "80" @default.
- W2920220762 countsByYear W29202207622019 @default.
- W2920220762 countsByYear W29202207622020 @default.
- W2920220762 countsByYear W29202207622021 @default.
- W2920220762 countsByYear W29202207622022 @default.
- W2920220762 countsByYear W29202207622023 @default.
- W2920220762 crossrefType "journal-article" @default.
- W2920220762 hasAuthorship W2920220762A5002345157 @default.
- W2920220762 hasAuthorship W2920220762A5004282576 @default.
- W2920220762 hasAuthorship W2920220762A5009470292 @default.
- W2920220762 hasAuthorship W2920220762A5043225490 @default.
- W2920220762 hasAuthorship W2920220762A5056797877 @default.
- W2920220762 hasAuthorship W2920220762A5058855999 @default.
- W2920220762 hasAuthorship W2920220762A5069303302 @default.
- W2920220762 hasAuthorship W2920220762A5072715696 @default.