Matches in SemOpenAlex for { <https://semopenalex.org/work/W2920238929> ?p ?o ?g. }
- W2920238929 abstract "Abstract Advances in genetic engineering have enabled the use of bacterial outer membrane vesicles (OMVs) to deliver vaccines, drugs and immunotherapy agents, as a strategy to circumvent biocompatibility and large-scale production issues associated with synthetic nanomaterials. We investigate bioengineered OMVs for contrast enhancement in optoacoustic (photoacoustic) imaging. We produce OMVs encapsulating biopolymer-melanin (OMV Mel ) using a bacterial strain expressing a tyrosinase transgene. Our results show that upon near-infrared light irradiation, OMV Mel generates strong optoacoustic signals appropriate for imaging applications. In addition, we show that OMV Mel builds up intense heat from the absorbed laser energy and mediates photothermal effects both in vitro and in vivo. Using multispectral optoacoustic tomography, we noninvasively monitor the spatio-temporal, tumour-associated OMV Mel distribution in vivo. This work points to the use of bioengineered vesicles as potent alternatives to synthetic particles more commonly employed for optoacoustic imaging, with the potential to enable both image enhancement and photothermal applications." @default.
- W2920238929 created "2019-03-11" @default.
- W2920238929 creator A5008353746 @default.
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- W2920238929 date "2019-03-07" @default.
- W2920238929 modified "2023-10-16" @default.
- W2920238929 title "Bioengineered bacterial vesicles as biological nano-heaters for optoacoustic imaging" @default.
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- W2920238929 doi "https://doi.org/10.1038/s41467-019-09034-y" @default.
- W2920238929 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6405847" @default.
- W2920238929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30846699" @default.
- W2920238929 hasPublicationYear "2019" @default.
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