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• W2920247639 startingPage "756" @default.
• W2920247639 abstract "Six new lathyrane diterpenoids (1-6) and 10 known analogues (7-16), were separated from the seeds of Euphorbia lathyris. The absolute configuration of 1 was determined by X-ray crystallography, and the C-2' configuration of 5 was elucidated by comparing experimental and calculated ECD data. These compounds were studied for their inhibition against nitric oxide (NO) generation induced by lipopolysaccharide in RAW264.7 macrophage cells. Compounds 1-3, 7, 9, 11, 13, 14, and 16 displayed inhibitory effects on NO production, with IC50 values of 2.6-26.0 μM. The new compound 1 (IC50 3.0 ± 1.1 μM), with no obvious cytotoxicity, was selected for further experiments. The production of cytokines such as IL-6 and IL-1β, as well as the protein expression of iNOS, NF-κB, and phosphorylated IκBα, was reduced by 1 dose-dependently. These results suggested that lathyrane diterpenoids may be used as potential anti-inflammatory agents and are worth being further researched." @default.
• W2920247639 created "2019-03-11" @default.
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• W2920247639 date "2019-02-28" @default.
• W2920247639 modified "2023-10-14" @default.
• W2920247639 title "Anti-inflammatory Lathyrane Diterpenoids from <i>Euphorbia lathyris</i>" @default.
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• W2920247639 doi "https://doi.org/10.1021/acs.jnatprod.8b00600" @default.
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