Matches in SemOpenAlex for { <https://semopenalex.org/work/W2920253635> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2920253635 abstract "Aging is the main challenge that humanity will face on the near future. Brain aging is associated with cognitive deficiencies and is the main risk factor for Alzheimer’s Disease (AD). AD is the most common neurodegenerative disease leading to dementia caused by the aggregation of amyloid-β peptide (Aβ). In this thesis, we have shown that neuronal aging leads to alteration in the ganglioside membrane content. Specifically, increased levels of GM1 ganglioside in membrane leads to a decrease in the calcium entry through NMDA receptors and a reduction of dendritic spines. Overall, pointing a role in the alterations in learning and memory associated to aging. On the other hand, we have showed the inhibitory effect of the human gamma immunoglobulins (IgG) in Aβ aggregation through the antigen-binding fragment (Fab), which binds to Aβ blocking fibrillation progression." @default.
- W2920253635 created "2019-03-11" @default.
- W2920253635 creator A5013532586 @default.
- W2920253635 creator A5051869697 @default.
- W2920253635 date "2018-09-07" @default.
- W2920253635 modified "2023-09-23" @default.
- W2920253635 title "Targeting aging and alzheimer's disease: from gm1 ganglioside to amyloid-beta peptide" @default.
- W2920253635 hasPublicationYear "2018" @default.
- W2920253635 type Work @default.
- W2920253635 sameAs 2920253635 @default.
- W2920253635 citedByCount "0" @default.
- W2920253635 crossrefType "dissertation" @default.
- W2920253635 hasAuthorship W2920253635A5013532586 @default.
- W2920253635 hasAuthorship W2920253635A5051869697 @default.
- W2920253635 hasConcept C126322002 @default.
- W2920253635 hasConcept C142724271 @default.
- W2920253635 hasConcept C159654299 @default.
- W2920253635 hasConcept C169760540 @default.
- W2920253635 hasConcept C177907266 @default.
- W2920253635 hasConcept C185592680 @default.
- W2920253635 hasConcept C203014093 @default.
- W2920253635 hasConcept C2776156579 @default.
- W2920253635 hasConcept C2777331542 @default.
- W2920253635 hasConcept C2777633098 @default.
- W2920253635 hasConcept C2779134260 @default.
- W2920253635 hasConcept C2779281246 @default.
- W2920253635 hasConcept C2779483572 @default.
- W2920253635 hasConcept C31705614 @default.
- W2920253635 hasConcept C502032728 @default.
- W2920253635 hasConcept C55493867 @default.
- W2920253635 hasConcept C71924100 @default.
- W2920253635 hasConcept C86803240 @default.
- W2920253635 hasConceptScore W2920253635C126322002 @default.
- W2920253635 hasConceptScore W2920253635C142724271 @default.
- W2920253635 hasConceptScore W2920253635C159654299 @default.
- W2920253635 hasConceptScore W2920253635C169760540 @default.
- W2920253635 hasConceptScore W2920253635C177907266 @default.
- W2920253635 hasConceptScore W2920253635C185592680 @default.
- W2920253635 hasConceptScore W2920253635C203014093 @default.
- W2920253635 hasConceptScore W2920253635C2776156579 @default.
- W2920253635 hasConceptScore W2920253635C2777331542 @default.
- W2920253635 hasConceptScore W2920253635C2777633098 @default.
- W2920253635 hasConceptScore W2920253635C2779134260 @default.
- W2920253635 hasConceptScore W2920253635C2779281246 @default.
- W2920253635 hasConceptScore W2920253635C2779483572 @default.
- W2920253635 hasConceptScore W2920253635C31705614 @default.
- W2920253635 hasConceptScore W2920253635C502032728 @default.
- W2920253635 hasConceptScore W2920253635C55493867 @default.
- W2920253635 hasConceptScore W2920253635C71924100 @default.
- W2920253635 hasConceptScore W2920253635C86803240 @default.
- W2920253635 hasLocation W29202536351 @default.
- W2920253635 hasOpenAccess W2920253635 @default.
- W2920253635 hasPrimaryLocation W29202536351 @default.
- W2920253635 hasRelatedWork W1984035411 @default.
- W2920253635 hasRelatedWork W2004819007 @default.
- W2920253635 hasRelatedWork W2023739625 @default.
- W2920253635 hasRelatedWork W2047522580 @default.
- W2920253635 hasRelatedWork W2051212454 @default.
- W2920253635 hasRelatedWork W2070138192 @default.
- W2920253635 hasRelatedWork W2079031778 @default.
- W2920253635 hasRelatedWork W2116141347 @default.
- W2920253635 hasRelatedWork W2120153709 @default.
- W2920253635 hasRelatedWork W2160383632 @default.
- W2920253635 hasRelatedWork W2368729090 @default.
- W2920253635 hasRelatedWork W2396604491 @default.
- W2920253635 hasRelatedWork W2431803917 @default.
- W2920253635 hasRelatedWork W2528558988 @default.
- W2920253635 hasRelatedWork W2612359837 @default.
- W2920253635 hasRelatedWork W2792517115 @default.
- W2920253635 hasRelatedWork W2810634108 @default.
- W2920253635 hasRelatedWork W3009098505 @default.
- W2920253635 hasRelatedWork W3171812685 @default.
- W2920253635 hasRelatedWork W2065386298 @default.
- W2920253635 isParatext "false" @default.
- W2920253635 isRetracted "false" @default.
- W2920253635 magId "2920253635" @default.
- W2920253635 workType "dissertation" @default.