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- W2920254002 abstract "Shape memory polymers are of great interest for biomedical applications. However, most stimuli used to trigger shape memory processes, including heat, light, electricity, magnetism, and pH are inconvenient and maybe harmful to the body. Here, we designed and fabricated a new shape memory porous scaffold using biocompatible and readily available water as the trigger. This scaffold was based on poly(fumaricacid-co-1,7-octadiene diepoxide-co-terephthalic acid) (PFOT) synthesized via epoxide ring-opening polymerization in one step. The PFOT scaffold promoted the adhesion, spreading, proliferation and function of cardiomyoblast H9C2 cells in a manner comparable to that for the poly(lactic-co-glycolic acid) scaffold. It exhibited an excellent water-responsive shape memory effect with a fixity and recovery ratio >97% and a shape-recovery process of several minutes, suitable for surgery. In addition, the PFOT scaffold presented good in vitro biodegradation. More importantly, PFOT contains extensive free hydroxyl groups and could be facilely functionalized and would be a promising smart material for multiple biomedical applications." @default.
- W2920254002 created "2019-03-11" @default.
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- W2920254002 date "2019-02-28" @default.
- W2920254002 modified "2023-10-14" @default.
- W2920254002 title "A Biocompatible, Biodegradable, and Functionalizable Copolyester and Its Application in Water-Responsive Shape Memory Scaffold" @default.
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- W2920254002 doi "https://doi.org/10.1021/acsbiomaterials.8b01337" @default.
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