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- W2920256957 endingPage "1176" @default.
- W2920256957 startingPage "1155" @default.
- W2920256957 abstract "In this paper, we describe a mathematical model of the cardiovascular system in human pregnancy. An automated, closed-loop 1D-0D modelling framework was developed, and we demonstrate its efficacy in (1) reproducing measured multi-variate cardiovascular variables (pulse pressure, total peripheral resistance and cardiac output) and (2) providing automated estimates of variables that have not been measured (uterine arterial and venous blood flow, pulse wave velocity, pulsatility index). This is the first model capable of estimating volumetric blood flow to the uterus via the utero-ovarian communicating arteries. It is also the first model capable of capturing wave propagation phenomena in the utero-ovarian circulation, which are important for the accurate estimation of arterial stiffness in contemporary obstetric practice. The model will provide a basis for future studies aiming to elucidate the physiological mechanisms underlying the dynamic properties (changing shapes) of vascular flow waveforms that are observed with advancing gestation. This in turn will facilitate the development of methods for the earlier detection of pathologies that have an influence on vascular structure and behaviour." @default.
- W2920256957 created "2019-03-11" @default.
- W2920256957 creator A5006864115 @default.
- W2920256957 creator A5043944428 @default.
- W2920256957 creator A5090650732 @default.
- W2920256957 creator A5090845825 @default.
- W2920256957 date "2019-03-05" @default.
- W2920256957 modified "2023-10-02" @default.
- W2920256957 title "A data-driven model to study utero-ovarian blood flow physiology during pregnancy" @default.
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