FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2920262430> ?p ?o ?g. }

• W2920262430 abstract "Though esophageal cancer is three to four times more common among males than females worldwide, this type of cancer still ranks in the top incidence among women, even more than the female specific cancer types. The occurrence is currently attributed to extrinsic factors, including tobacco use and alcohol consumption. However, limited attention has been given to gender-specific intrinsic genetic factors, especially in female. We re-annotated a large cohort of microarrays on 179 ESCC patients and identified female-specific differently expressed lncRNAs. The associations between FMR1-AS1 and the risk and prognosis of ESCC were examined in 206 diagnosed patients from eastern China and validated in 188 additional patients from southern China. The effects of FMR1-AS1 on the malignant phenotypes on female ESCC cells were detected in vitro and in vivo. ChIRP-MS, reporter gene assays and EMSA were conducted to identify the interaction and regulation among FMR1-AS1, TLR7 and NFκB. We found FMR1-AS1 expression is exclusively altered and closely associated with the level of sXCI in female ESCC patients, and its overexpression may correlate to poor clinical outcome. ChIRP-MS data indicate that FMR1-AS1 could be packaged into exosomes and released into tumor microenvironment. Functional studies demonstrated that FMR1-AS1 could bind to endosomal toll-like receptor 7 (TLR7) and activate downstream TLR7-NFκB signaling, promoting the c-Myc expression, thus inducing ESCC cell proliferation, anti-apoptosis and invasion ability. Exosome incubation and co-xenograft assay indicate that FMR1-AS1 exosomes may secreted from ESCC CSCs, transferring stemness phenotypes to recipient non-CSCs in tumor microenvironment. Furthermore, we also found a correlation between the serum levels of FMR1-AS1 and the overall survival (OS) of the female ESCC patients. Our results highlighted exosomal FMR1-AS1 in maintaining CSC dynamic interconversion state through the mechanism of activating TLR7-NFκB signaling, upregulating c-Myc level in recipient cells, which may be taken as an attractive target approach for advancing current precision cancer therapeutics in female patients." @default.
• W2920262430 created "2019-03-11" @default.
• W2920262430 creator A5015158690 @default.
• W2920262430 creator A5017170633 @default.
• W2920262430 creator A5020424535 @default.
• W2920262430 creator A5023890889 @default.
• W2920262430 creator A5037475520 @default.
• W2920262430 creator A5047916176 @default.
• W2920262430 creator A5049763932 @default.
• W2920262430 creator A5051970004 @default.
• W2920262430 creator A5079875804 @default.
• W2920262430 date "2019-02-08" @default.
• W2920262430 modified "2023-10-14" @default.
• W2920262430 title "Exosomal FMR1-AS1 facilitates maintaining cancer stem-like cell dynamic equilibrium via TLR7/NFκB/c-Myc signaling in female esophageal carcinoma" @default.
• W2920262430 cites W1557776005 @default.
• W2920262430 cites W1716301446 @default.
• W2920262430 cites W1736155067 @default.
• W2920262430 cites W1824585857 @default.
• W2920262430 cites W1825703274 @default.
• W2920262430 cites W1828298093 @default.
• W2920262430 cites W1951507118 @default.
• W2920262430 cites W1967867693 @default.
• W2920262430 cites W1969072247 @default.
• W2920262430 cites W1969759955 @default.
• W2920262430 cites W1974720903 @default.
• W2920262430 cites W1975728749 @default.
• W2920262430 cites W1980153364 @default.
• W2920262430 cites W1994391392 @default.
• W2920262430 cites W1996073862 @default.
• W2920262430 cites W2001525415 @default.
• W2920262430 cites W2027798298 @default.
• W2920262430 cites W2041770101 @default.
• W2920262430 cites W2047566408 @default.
• W2920262430 cites W2049717090 @default.
• W2920262430 cites W2051761998 @default.
• W2920262430 cites W2057419005 @default.
• W2920262430 cites W2059794606 @default.
• W2920262430 cites W2068862319 @default.
• W2920262430 cites W2079162697 @default.
• W2920262430 cites W2084770914 @default.
• W2920262430 cites W2087032228 @default.
• W2920262430 cites W2095945017 @default.
• W2920262430 cites W2096847064 @default.
• W2920262430 cites W2104005622 @default.
• W2920262430 cites W2106787323 @default.
• W2920262430 cites W2113089439 @default.
• W2920262430 cites W2119293746 @default.
• W2920262430 cites W2137840425 @default.
• W2920262430 cites W2140654997 @default.
• W2920262430 cites W2145968882 @default.
• W2920262430 cites W2146573461 @default.
• W2920262430 cites W2148430424 @default.
• W2920262430 cites W2164333612 @default.
• W2920262430 cites W2296538017 @default.
• W2920262430 cites W2342038157 @default.
• W2920262430 cites W2523682386 @default.
• W2920262430 cites W2559922077 @default.
• W2920262430 cites W2586119928 @default.
• W2920262430 cites W2587972368 @default.
• W2920262430 cites W2609322822 @default.
• W2920262430 cites W2803516105 @default.
• W2920262430 cites W2893261070 @default.
• W2920262430 cites W2904169994 @default.
• W2920262430 doi "https://doi.org/10.1186/s12943-019-0949-7" @default.
• W2920262430 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6367809" @default.
• W2920262430 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30736860" @default.
• W2920262430 hasPublicationYear "2019" @default.
• W2920262430 type Work @default.
• W2920262430 sameAs 2920262430 @default.
• W2920262430 citedByCount "82" @default.
• W2920262430 countsByYear W29202624302019 @default.
• W2920262430 countsByYear W29202624302020 @default.
• W2920262430 countsByYear W29202624302021 @default.
• W2920262430 countsByYear W29202624302022 @default.
• W2920262430 countsByYear W29202624302023 @default.
• W2920262430 crossrefType "journal-article" @default.
• W2920262430 hasAuthorship W2920262430A5015158690 @default.
• W2920262430 hasAuthorship W2920262430A5017170633 @default.
• W2920262430 hasAuthorship W2920262430A5020424535 @default.
• W2920262430 hasAuthorship W2920262430A5023890889 @default.
• W2920262430 hasAuthorship W2920262430A5037475520 @default.
• W2920262430 hasAuthorship W2920262430A5047916176 @default.
• W2920262430 hasAuthorship W2920262430A5049763932 @default.
• W2920262430 hasAuthorship W2920262430A5051970004 @default.
• W2920262430 hasAuthorship W2920262430A5079875804 @default.
• W2920262430 hasBestOaLocation W29202624301 @default.
• W2920262430 hasConcept C121608353 @default.
• W2920262430 hasConcept C126322002 @default.
• W2920262430 hasConcept C502942594 @default.
• W2920262430 hasConcept C54355233 @default.
• W2920262430 hasConcept C71924100 @default.
• W2920262430 hasConcept C86803240 @default.
• W2920262430 hasConceptScore W2920262430C121608353 @default.
• W2920262430 hasConceptScore W2920262430C126322002 @default.
• W2920262430 hasConceptScore W2920262430C502942594 @default.
• W2920262430 hasConceptScore W2920262430C54355233 @default.
• W2920262430 hasConceptScore W2920262430C71924100 @default.
• W2920262430 hasConceptScore W2920262430C86803240 @default.
• W2920262430 hasIssue "1" @default.
• W2920262430 hasLocation W29202624301 @default.

• next