FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2920287735> ?p ?o ?g. }

• W2920287735 abstract "The voltage-gated sodium channel subunit β4 (SCN4B) regulates neuronal activity by modulating channel gating and has been implicated in ethanol consumption in rodent models and human alcoholics. However, the functional role for Scn4b in ethanol-mediated behaviors is unknown. We determined if genetic global knockout (KO) or targeted knockdown of Scn4b in the central nucleus of the amygdala (CeA) altered ethanol drinking or related behaviors. We used four different ethanol consumption procedures (continuous and intermittent two-bottle choice (2BC), drinking-in-the dark and chronic intermittent ethanol vapor) and found that male and female Scn4b KO mice did not differ from their wild-type (WT) littermates in ethanol consumption in any of the tests. Knockdown of Scn4b mRNA in the CeA also did not alter 2BC ethanol drinking. However, Scn4b KO mice showed longer duration of the loss of righting reflex induced by ethanol, gaboxadol, pentobarbital and ketamine. KO mice showed slower recovery to basal levels of handling-induced convulsions after ethanol injection, which is consistent with the increased sedative effects observed in these mice. However, Scn4b KO mice did not differ in the severity of acute ethanol withdrawal. Acoustic startle responses, ethanol-induced hypothermia and clearance of blood ethanol also did not differ between the genotypes. There were also no functional differences in the membrane properties or excitability of CeA neurons from Scn4b KO and WT mice. Although we found no evidence that Scn4b regulates ethanol consumption in mice, it was involved in the acute hypnotic effects of ethanol and other sedatives." @default.
• W2920287735 created "2019-03-11" @default.
• W2920287735 creator A5001704340 @default.
• W2920287735 creator A5010388465 @default.
• W2920287735 creator A5015541900 @default.
• W2920287735 creator A5027784997 @default.
• W2920287735 creator A5041184076 @default.
• W2920287735 creator A5060479945 @default.
• W2920287735 creator A5061431867 @default.
• W2920287735 creator A5063608221 @default.
• W2920287735 creator A5064679989 @default.
• W2920287735 creator A5072610252 @default.
• W2920287735 creator A5073567262 @default.
• W2920287735 creator A5082855062 @default.
• W2920287735 date "2019-05-02" @default.
• W2920287735 modified "2023-10-16" @default.
• W2920287735 title "<i>Scn4b</i> regulates the hypnotic effects of ethanol and other sedative drugs" @default.
• W2920287735 cites W1578375215 @default.
• W2920287735 cites W1761714741 @default.
• W2920287735 cites W1937176890 @default.
• W2920287735 cites W1964909924 @default.
• W2920287735 cites W1971108844 @default.
• W2920287735 cites W1971831953 @default.
• W2920287735 cites W1977546136 @default.
• W2920287735 cites W1983187084 @default.
• W2920287735 cites W1984081894 @default.
• W2920287735 cites W1986726759 @default.
• W2920287735 cites W1987256529 @default.
• W2920287735 cites W1989812125 @default.
• W2920287735 cites W1996835303 @default.
• W2920287735 cites W1997270233 @default.
• W2920287735 cites W1999486752 @default.
• W2920287735 cites W2016149358 @default.
• W2920287735 cites W2047782981 @default.
• W2920287735 cites W2049973503 @default.
• W2920287735 cites W2052338190 @default.
• W2920287735 cites W2052407013 @default.
• W2920287735 cites W2057104160 @default.
• W2920287735 cites W2061119206 @default.
• W2920287735 cites W2068137434 @default.
• W2920287735 cites W2073489133 @default.
• W2920287735 cites W2079044818 @default.
• W2920287735 cites W2079172827 @default.
• W2920287735 cites W2092830214 @default.
• W2920287735 cites W2123606173 @default.
• W2920287735 cites W2161798290 @default.
• W2920287735 cites W2163695767 @default.
• W2920287735 cites W2411302073 @default.
• W2920287735 cites W2417072335 @default.
• W2920287735 cites W2537274910 @default.
• W2920287735 cites W2586599850 @default.
• W2920287735 cites W2624850536 @default.
• W2920287735 cites W2791331713 @default.
• W2920287735 doi "https://doi.org/10.1111/gbb.12562" @default.
• W2920287735 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6612599" @default.
• W2920287735 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30817077" @default.
• W2920287735 hasPublicationYear "2019" @default.
• W2920287735 type Work @default.
• W2920287735 sameAs 2920287735 @default.
• W2920287735 citedByCount "3" @default.
• W2920287735 countsByYear W29202877352020 @default.
• W2920287735 countsByYear W29202877352023 @default.
• W2920287735 crossrefType "journal-article" @default.
• W2920287735 hasAuthorship W2920287735A5001704340 @default.
• W2920287735 hasAuthorship W2920287735A5010388465 @default.
• W2920287735 hasAuthorship W2920287735A5015541900 @default.
• W2920287735 hasAuthorship W2920287735A5027784997 @default.
• W2920287735 hasAuthorship W2920287735A5041184076 @default.
• W2920287735 hasAuthorship W2920287735A5060479945 @default.
• W2920287735 hasAuthorship W2920287735A5061431867 @default.
• W2920287735 hasAuthorship W2920287735A5063608221 @default.
• W2920287735 hasAuthorship W2920287735A5064679989 @default.
• W2920287735 hasAuthorship W2920287735A5072610252 @default.
• W2920287735 hasAuthorship W2920287735A5073567262 @default.
• W2920287735 hasAuthorship W2920287735A5082855062 @default.
• W2920287735 hasBestOaLocation W29202877352 @default.
• W2920287735 hasConcept C126322002 @default.
• W2920287735 hasConcept C131783052 @default.
• W2920287735 hasConcept C134018914 @default.
• W2920287735 hasConcept C170493617 @default.
• W2920287735 hasConcept C182704531 @default.
• W2920287735 hasConcept C185592680 @default.
• W2920287735 hasConcept C2776755955 @default.
• W2920287735 hasConcept C2777389121 @default.
• W2920287735 hasConcept C2777390192 @default.
• W2920287735 hasConcept C2777602617 @default.
• W2920287735 hasConcept C2778195246 @default.
• W2920287735 hasConcept C2780161600 @default.
• W2920287735 hasConcept C2780795376 @default.
• W2920287735 hasConcept C2780930544 @default.
• W2920287735 hasConcept C2910067630 @default.
• W2920287735 hasConcept C42219234 @default.
• W2920287735 hasConcept C55493867 @default.
• W2920287735 hasConcept C71924100 @default.
• W2920287735 hasConcept C83974742 @default.
• W2920287735 hasConcept C98274493 @default.
• W2920287735 hasConceptScore W2920287735C126322002 @default.
• W2920287735 hasConceptScore W2920287735C131783052 @default.
• W2920287735 hasConceptScore W2920287735C134018914 @default.
• W2920287735 hasConceptScore W2920287735C170493617 @default.

• next