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• W2920294825 abstract "Abstract Neu-medullocytes, which were previously identified and named by our group, are sialidase (neuraminidase)-positive B cells that express immunoglobulin and Mac-1 in the mouse thymus. Recently, B cells that migrated into the thymus were reported to express autoimmune regulator (AIRE) and to contribute to self-tolerance. We sought to determine whether Neu-medullocytes also express AIRE. We obtained positive results by triple staining Neu-medullocytes for in situ sialidase activity, anti-AIRE, and either anti-IgG or anti-IgM antibodies and observing the staining with confocal microscopy. Additional molecules including CD5, IgM, major histocompatibility complex (MHC) Class II, and neuraminidase 1 (NEU1) were found in sialidase-positive cells independently. The real-time PCR results suggest that the primary sialidase in AIRE-positive cells is neuraminidase 2 (NEU2). Furthermore, some of the AIRE-positive medullary thymic epithelial cells also clearly showed sialidase activity when a triple staining of sialidase activity, anti-AIRE, and Ulex europaeus agglutinin-1 (UEA-1) was performed. Neu-medullocytes may present Aire -dependent antigens for negative selection. We discuss the negative selection steps in consideration of sialidases and sialic acids." @default.
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• W2920294825 date "2019-01-29" @default.
• W2920294825 modified "2023-10-05" @default.
• W2920294825 title "Neu-medullocytes, sialidase-positive B cells in the thymus, express autoimmune regulator (AIRE)" @default.
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• W2920294825 doi "https://doi.org/10.1038/s41598-018-37225-y" @default.
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