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• W2920324197 abstract "Poor O2 supply to the infiltrated immune cells in the joint synovium of rheumatoid arthritis (RA) up-regulates hypoxia-inducible factor (HIF-1α) expression and induces reactive oxygen species (ROS) generation, both of which exacerbate synovial inflammation. Synovial inflammation in RA can be resolved by eliminating pro-inflammatory M1 macrophages and inducing anti-inflammatory M2 macrophages. Because hypoxia and ROS in the RA synovium play a crucial role in the induction of M1 macrophages and reduction of M2 macrophages, herein, we develop manganese ferrite and ceria nanoparticle-anchored mesoporous silica nanoparticles (MFC-MSNs) that can synergistically scavenge ROS and produce O2 for reducing M1 macrophage levels and inducing M2 macrophages for RA treatment. MFC-MSNs exhibit a synergistic effect on O2 generation and ROS scavenging that is attributed to the complementary reaction of ceria nanoparticles (NPs) that can scavenge intermediate hydroxyl radicals generated by manganese ferrite NPs in the process of O2 generation during the Fenton reaction, leading to the efficient polarization of M1 to M2 macrophages both in vitro and in vivo. Intra-articular administration of MFC-MSNs to rat RA models alleviated hypoxia, inflammation, and pathological features in the joint. Furthermore, MSNs were used as a drug-delivery vehicle, releasing the anti-rheumatic drug methotrexate in a sustained manner to augment the therapeutic effect of MFC-MSNs. This study highlights the therapeutic potential of MFC-MSNs that simultaneously generate O2 and scavenge ROS, subsequently driving inflammatory macrophages to the anti-inflammatory subtype for RA treatment." @default.
• W2920324197 created "2019-03-11" @default.
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• W2920324197 date "2019-03-04" @default.
• W2920324197 modified "2023-10-14" @default.
• W2920324197 title "Synergistic Oxygen Generation and Reactive Oxygen Species Scavenging by Manganese Ferrite/Ceria Co-decorated Nanoparticles for Rheumatoid Arthritis Treatment" @default.
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• W2920324197 cites W1846935465 @default.
• W2920324197 cites W1968077631 @default.
• W2920324197 cites W1971496705 @default.
• W2920324197 cites W1981053807 @default.
• W2920324197 cites W1981056356 @default.
• W2920324197 cites W1985994131 @default.
• W2920324197 cites W2004233759 @default.
• W2920324197 cites W2011676749 @default.
• W2920324197 cites W2011815515 @default.
• W2920324197 cites W2018507306 @default.
• W2920324197 cites W2029231128 @default.
• W2920324197 cites W2029827839 @default.
• W2920324197 cites W2030824935 @default.
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• W2920324197 cites W2045350680 @default.
• W2920324197 cites W2054472394 @default.
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• W2920324197 cites W2055901626 @default.
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• W2920324197 cites W2110639369 @default.
• W2920324197 cites W2118969052 @default.
• W2920324197 cites W2129051084 @default.
• W2920324197 cites W2129176918 @default.
• W2920324197 cites W2131255599 @default.
• W2920324197 cites W2134729461 @default.
• W2920324197 cites W2134798397 @default.
• W2920324197 cites W2138272556 @default.
• W2920324197 cites W2149472502 @default.
• W2920324197 cites W2155702314 @default.
• W2920324197 cites W2193672635 @default.
• W2920324197 cites W2229268188 @default.
• W2920324197 cites W2266539117 @default.
• W2920324197 cites W2268788143 @default.
• W2920324197 cites W2278059930 @default.
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• W2920324197 cites W2294574674 @default.
• W2920324197 cites W2305745682 @default.
• W2920324197 cites W2310415701 @default.
• W2920324197 cites W2320182137 @default.
• W2920324197 cites W2322744662 @default.
• W2920324197 cites W2328216958 @default.
• W2920324197 cites W2395249393 @default.
• W2920324197 cites W2413193118 @default.
• W2920324197 cites W2417259144 @default.
• W2920324197 cites W2533707421 @default.
• W2920324197 cites W2577396496 @default.
• W2920324197 cites W2689318812 @default.
• W2920324197 cites W2736417543 @default.
• W2920324197 cites W2737866071 @default.
• W2920324197 cites W2774325261 @default.
• W2920324197 cites W2782879922 @default.
• W2920324197 cites W2787460561 @default.
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• W2920324197 doi "https://doi.org/10.1021/acsnano.8b08785" @default.
• W2920324197 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30830763" @default.
• W2920324197 hasPublicationYear "2019" @default.
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