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• W2920341705 endingPage "1355" @default.
• W2920341705 startingPage "1342" @default.
• W2920341705 abstract "MicroRNAs (miRNAs) have been implicated in β cells dysfunction. Previous studies indicated that miR-127 was specifically abundant in β cells and one of its target genes, Kif3b, promoted cell proliferation. However, the impact of the miR-127-Kif3b axis on β cells remains unknown. In this study, we revealed that miR-127 level was declined both in islets from the mice with a high-fat diet and in MIN6 cells with elevated glucose treatment. The elevated level of miR-127 attenuated β cell proliferation by repressing Kif3b expression without affecting apoptosis and cell cycle, and it dampened insulin secretion. Moreover, β cell-derived miR-127 could also affect the islet endothelial cell-line, MS1, in vitro via the transfer of extracellular vesicles (EVs). Treating MS1 cells with the EVs secreted by MIN6 cells exhibited a higher ability in cell migration and tube formation. However, this effect was abolished by the miR-127 inhibitor co-cultured with EVs-treated MS1 cells. Thus, we define that miR-127 is a crucial regulator of insulin secretion and cell proliferation in pancreatic β cells as well as a potential functional regulation factor in islet endothelial cells." @default.
• W2920341705 created "2019-03-11" @default.
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• W2920341705 date "2019-03-01" @default.
• W2920341705 modified "2023-09-26" @default.
• W2920341705 title "MicroRNA-127 inhibits cell proliferation via targeting Kif3b in pancreatic β cells" @default.
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• W2920341705 doi "https://doi.org/10.18632/aging.101835" @default.
• W2920341705 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6428088" @default.
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• W2920341705 hasPublicationYear "2019" @default.
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