Matches in SemOpenAlex for { <https://semopenalex.org/work/W2920383669> ?p ?o ?g. }
- W2920383669 endingPage "302" @default.
- W2920383669 startingPage "281" @default.
- W2920383669 abstract "The rising cost of drug development has necessitated the search for efficient approaches for the discovery of novel drugs. Such difficulty arises from the fact that promising lead compounds would need to be further scrutinized via preclinical and clinical studies so as to characterize their absorption, distribution, metabolism, excretion, and toxicity in order to verify their safety for clinical use. In this respect, drug repositioning/repurposing represents an attractive venue for the discovery of novel therapeutic indications for existing food and drug administration-approved drugs, which in a nutshell repurposes old drugs for treating new diseases for which they were not originally developed. Computational approaches have been instrumental in drug repositioning efforts as they make use of existing biological and chemical data to uncover new therapeutic indications by relying on the concept that similar compounds bind to similar targets. Quantitative structure-activity relationship (QSAR) is a powerful ligand-based approach that correlates structural features of compounds with their observed biological activity against a single target protein. Proteochemometric modeling (PCM) extends QSAR to an extra dimension by allowing several target proteins to be considered in a single model. This chapter briefly explores the concepts of polypharmacology and computational drug discovery and finally examines the use of PCM for drug repositioning." @default.
- W2920383669 created "2019-03-11" @default.
- W2920383669 creator A5009545970 @default.
- W2920383669 creator A5043577834 @default.
- W2920383669 creator A5069155677 @default.
- W2920383669 creator A5081085064 @default.
- W2920383669 creator A5081984122 @default.
- W2920383669 creator A5091844409 @default.
- W2920383669 date "2019-01-01" @default.
- W2920383669 modified "2023-09-25" @default.
- W2920383669 title "Proteochemometric Modeling for Drug Repositioning" @default.
- W2920383669 cites W1489237918 @default.
- W2920383669 cites W1500036797 @default.
- W2920383669 cites W1651886044 @default.
- W2920383669 cites W1725133249 @default.
- W2920383669 cites W1898375943 @default.
- W2920383669 cites W1940331911 @default.
- W2920383669 cites W1950227823 @default.
- W2920383669 cites W1964057811 @default.
- W2920383669 cites W1964124955 @default.
- W2920383669 cites W1971315259 @default.
- W2920383669 cites W1975420361 @default.
- W2920383669 cites W1975538973 @default.
- W2920383669 cites W1977282213 @default.
- W2920383669 cites W1977972453 @default.
- W2920383669 cites W1981775239 @default.
- W2920383669 cites W1983479017 @default.
- W2920383669 cites W1986124907 @default.
- W2920383669 cites W1995530068 @default.
- W2920383669 cites W1996544703 @default.
- W2920383669 cites W1996630442 @default.
- W2920383669 cites W1999802559 @default.
- W2920383669 cites W2003488516 @default.
- W2920383669 cites W2004117957 @default.
- W2920383669 cites W2017398555 @default.
- W2920383669 cites W2018518196 @default.
- W2920383669 cites W2029789136 @default.
- W2920383669 cites W2031082559 @default.
- W2920383669 cites W2031390939 @default.
- W2920383669 cites W2033591223 @default.
- W2920383669 cites W2033757486 @default.
- W2920383669 cites W2034290945 @default.
- W2920383669 cites W2034763638 @default.
- W2920383669 cites W2034981836 @default.
- W2920383669 cites W2041729187 @default.
- W2920383669 cites W2050847085 @default.
- W2920383669 cites W2051503575 @default.
- W2920383669 cites W2055786859 @default.
- W2920383669 cites W2062941476 @default.
- W2920383669 cites W2064899634 @default.
- W2920383669 cites W2068819452 @default.
- W2920383669 cites W2071472412 @default.
- W2920383669 cites W2075904044 @default.
- W2920383669 cites W2079266488 @default.
- W2920383669 cites W2079639517 @default.
- W2920383669 cites W2087278935 @default.
- W2920383669 cites W2087983371 @default.
- W2920383669 cites W2096713193 @default.
- W2920383669 cites W2097363837 @default.
- W2920383669 cites W2098972483 @default.
- W2920383669 cites W2100076566 @default.
- W2920383669 cites W2102377211 @default.
- W2920383669 cites W2105120272 @default.
- W2920383669 cites W2106440817 @default.
- W2920383669 cites W2106591444 @default.
- W2920383669 cites W2108103746 @default.
- W2920383669 cites W2112411768 @default.
- W2920383669 cites W2114704115 @default.
- W2920383669 cites W2118146791 @default.
- W2920383669 cites W2118339791 @default.
- W2920383669 cites W2121384662 @default.
- W2920383669 cites W2122995608 @default.
- W2920383669 cites W2126624551 @default.
- W2920383669 cites W2127587566 @default.
- W2920383669 cites W2127905857 @default.
- W2920383669 cites W2129434099 @default.
- W2920383669 cites W2130119642 @default.
- W2920383669 cites W2130606967 @default.
- W2920383669 cites W2134697397 @default.
- W2920383669 cites W2138389332 @default.
- W2920383669 cites W2142325821 @default.
- W2920383669 cites W2144377773 @default.
- W2920383669 cites W2151338484 @default.
- W2920383669 cites W2162525969 @default.
- W2920383669 cites W2162579416 @default.
- W2920383669 cites W2162830271 @default.
- W2920383669 cites W2163368193 @default.
- W2920383669 cites W2167261147 @default.
- W2920383669 cites W2167960276 @default.
- W2920383669 cites W2168990503 @default.
- W2920383669 cites W2177317049 @default.
- W2920383669 cites W2199312772 @default.
- W2920383669 cites W2204695023 @default.
- W2920383669 cites W2221253132 @default.
- W2920383669 cites W2223809533 @default.
- W2920383669 cites W2268071782 @default.
- W2920383669 cites W2273267066 @default.
- W2920383669 cites W2278874757 @default.