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- W2920397651 abstract "Dietary intake is implicated in the pathogenesis of non-communicable diseases, especially those affecting metabolism. Many non-communicable diseases are mediated by alterations in antioxidant activity and chronic inflammation with its resultant effects. Developmental programming causes offspring of parents with particular metabolic phenotypes to adopt predisposition to these phenotypes during development.This study investigated the effects of maternal macronutrient consumption in two generations of rats (F0 and F1) on programming of antioxidant activity and inflammatory status in F2 offspring.The F0 and F1 animals were fed on different macronutrient diets (control, HCD, HFD, HPD) for nine weeks and mated, however F2 animals were fed on standard chow. Glutathione (GSH), Glutathione disulphide (GSSG), lipid peroxidation, Interleukin-6 (IL-6), and Transforming Growth Factor- β (TGF-β) were then determined in F0, F1 and F2 generations using standard methods.In all test groups, the F2 offspring reflected similar changes in measured variables as observed in F0 and F1 animals.The results of the study suggest that dietary macronutrient intake in parent generations, could have an effect on developmental programming of antioxidant activity and inflammatory status in offspring." @default.
- W2920397651 created "2019-03-11" @default.
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- W2920397651 date "2019-04-01" @default.
- W2920397651 modified "2023-09-24" @default.
- W2920397651 title "Dietary intake of parents affects antioxidant activity and inflammatory status in F2 offspring" @default.
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- W2920397651 doi "https://doi.org/10.1016/j.lfs.2019.02.055" @default.
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