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• W2920403745 abstract "Spinal cord injury (SCI) is a devastating condition with variability in injury mechanisms and neurologic recovery. Spinal cord impairment after SCI is measured and classified by a widely accepted standard neurological examination. In the very acute stages post-injury, however, this examination is extremely challenging (and often impossible) to conduct and has modest prognostic value in terms of neurological recovery. The lack of objective tools to classify injury severity and predict outcome is a barrier for clinical trials and thwarts development of therapies for those with SCI. Biological markers (biomarkers) represent a promising, complementary approach to these challenges because they represent an unbiased approach to classify injury severity and predict neurological outcome. Identification of a suitable panel of molecular biomarkers would comprise a fundamental shift in how patients with acute SCI are evaluated, stratified, and treated in clinical trials. MicroRNA are attractive biomarker candidates in neurological disorders for several reasons, including their stability in biological fluids, their conservation between humans and model mammals, and their tissue specificity. In this study, we used next-generation sequencing to identify microRNA associated with injury severity within the cerebrospinal fluid (CSF) and serum of human patients with acute SCI. The CSF and serum samples were obtained 1–5 days post-injury from 39 patients with acute SCI (24 American Spinal Injury Association Impairment Scale [AIS] A, 8 AIS B, 7 AIS C) and from five non-SCI controls. We identified a severity-dependent pattern of change in microRNA expression in CSF and identified a set of microRNA that are diagnostic of baseline AIS classification and prognostic of neurological outcome six months post-injury. The data presented here provide a comprehensive description of the CSF and serum microRNA expression changes that occur after acute human SCI. This data set reveals microRNA candidates that warrant further evaluation as biomarkers of injury severity after SCI and as key regulators in other neurological disorders." @default.
• W2920403745 created "2019-03-11" @default.
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• W2920403745 date "2019-08-01" @default.
• W2920403745 modified "2023-10-16" @default.
• W2920403745 title "MicroRNA Biomarkers in Cerebrospinal Fluid and Serum Reflect Injury Severity in Human Acute Traumatic Spinal Cord Injury" @default.
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• W2920403745 cites W1584776808 @default.
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• W2920403745 cites W1962605277 @default.
• W2920403745 cites W1976870104 @default.
• W2920403745 cites W1984265555 @default.
• W2920403745 cites W1986005801 @default.
• W2920403745 cites W1992549770 @default.
• W2920403745 cites W1993165035 @default.
• W2920403745 cites W1995405296 @default.
• W2920403745 cites W1996301670 @default.
• W2920403745 cites W1999869217 @default.
• W2920403745 cites W2003286659 @default.
• W2920403745 cites W2009330906 @default.
• W2920403745 cites W2011943543 @default.
• W2920403745 cites W2013092651 @default.
• W2920403745 cites W2014958031 @default.
• W2920403745 cites W2035904405 @default.
• W2920403745 cites W2037119008 @default.
• W2920403745 cites W2038019937 @default.
• W2920403745 cites W2041349035 @default.
• W2920403745 cites W2046773304 @default.
• W2920403745 cites W2047606645 @default.
• W2920403745 cites W2050322930 @default.
• W2920403745 cites W2062993238 @default.
• W2920403745 cites W2064856872 @default.
• W2920403745 cites W2073152245 @default.
• W2920403745 cites W2077847097 @default.
• W2920403745 cites W2085789455 @default.
• W2920403745 cites W2099359509 @default.
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• W2920403745 cites W2115093090 @default.
• W2920403745 cites W2124774548 @default.
• W2920403745 cites W2130305733 @default.
• W2920403745 cites W2132190410 @default.
• W2920403745 cites W2135920287 @default.
• W2920403745 cites W2144339761 @default.
• W2920403745 cites W2155749005 @default.
• W2920403745 cites W2169336810 @default.
• W2920403745 cites W2169744240 @default.
• W2920403745 cites W2171540336 @default.
• W2920403745 cites W2179438025 @default.
• W2920403745 cites W2191899786 @default.
• W2920403745 cites W2235837253 @default.
• W2920403745 cites W2316255286 @default.
• W2920403745 cites W2474824777 @default.
• W2920403745 cites W2514255391 @default.
• W2920403745 cites W2531862582 @default.
• W2920403745 cites W2564254866 @default.
• W2920403745 cites W2594161232 @default.
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• W2920403745 cites W2770770994 @default.
• W2920403745 cites W2792925567 @default.
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• W2920403745 doi "https://doi.org/10.1089/neu.2018.6256" @default.
• W2920403745 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30827169" @default.
• W2920403745 hasPublicationYear "2019" @default.
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