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- W2920403874 abstract "We have previously demonstrated a 10% reduction in peak expira- tory flow (PEF) in healthy adults following a breathhold at total lung capacity (TLC). This fall was attributed to dissipation of airway wall viscoelasticity, increas- ing airway wall compliance (Caw). To investigate this phenomenon in children and to determine whether the effect of breathhold would be greater in asthmatics than in normal children, 15 asthmatics and 14 normal children (aged 10-15 yrs) performed maximal post expirations (MFE) with and without a 5 s breathhold at TLC. The entire study was repeated follow- ing the inhalation of salbutamol (800 µg) to relax the airway smooth muscle (and to increase Caw). Breathhold at TLC resulted in a significant decrease in PEF both in the asthma- tics (group mean fall 5.8%; p<0.01) and normal children (group mean fall 10.3%; p<0.05). Salbutamol diminished this fall, becoming nonsignificant in the normal children. Similar patterns were also seen in forced expiratory volume in one sec- ond (FEV1) and in maximal expiratory flow at 50% vital capacity (V'50). These data are consistent with the proposal that breathhold at total lung capa- city dissipated viscoelastic energy (increasing airway compliance) and decreased maximal expiratory flows both in normal and asthmatic children. They also demon- strate the need to standardize the forced vital capacity manoeuvre to decrease the variability in the flows recorded during the subsequent forced expiration." @default.
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- W2920403874 date "1996-01-01" @default.
- W2920403874 modified "2023-09-26" @default.
- W2920403874 title "The influence of breathhold on peak expiratory flow in normal and asthmatic children" @default.
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