FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2920406506> ?p ?o ?g. }

• W2920406506 endingPage "84" @default.
• W2920406506 startingPage "73" @default.
• W2920406506 abstract "BackgroundGlucagon-like peptide-1 (GLP-1) and its based agents improve glycemic control. Although their attenuating effect on hepatic glucose output has drawn our attention for decades, the potential mechanisms remain unclear.MethodsCytokine array kit was used to assess cytokine profiles in db/db mice and mouse primary hepatocytes treated with exenatide (exendin-4). Two diabetic mouse models (db/db and Pax6m/+) were treated with a GLP-1 analog exenatide or liraglutide. The expression and secretion of fibroblast growth factor 21 (FGF21) in the livers of diabetic mice, primary mouse and human hepatocytes, and the human hepatic cell line HepG2 treated with or without GLP-1 analog were measured. Blockage of FGF21 with neutralizing antibody or siRNA, or hepatocytes isolated from Fgf21 knockout mice were used, and the expression and activity of key enzymes in gluconeogenesis were analyzed. Serum FGF21 level was evaluated in patients with type 2 diabetes (T2D) receiving exenatide treatment.FindingsUtilizing the cytokine array, we identified that FGF21 secretion was upregulated by exenatide (exendin-4). Similarly, FGF21 production in hepatocytes was stimulated by exenatide or liraglutide. FGF21 blockage attenuated the inhibitory effects of the GLP-1 analogs on hepatic glucose output. Similar results were also observed in primary hepatocytes from Fgf21 knockout mice. Furthermore, exenatide treatment increased serum FGF21 level in patients with T2D, particularly in those with better glucose control.InterpretationWe identify that function of GLP-1 in inhibiting hepatic glucose output is mediated via the liver hormone FGF21. Thus, we provide a new extra-pancreatic mechanism by which GLP-1 regulates glucose homeostasis.FundNational Key Research and Development Program of China, the National Natural Science Foundation of China, the Natural Science Foundation of Beijing and Peking University Medicine Seed Fund for Interdisciplinary Research." @default.
• W2920406506 created "2019-03-11" @default.
• W2920406506 creator A5006301048 @default.
• W2920406506 creator A5016812789 @default.
• W2920406506 creator A5019872937 @default.
• W2920406506 creator A5025015130 @default.
• W2920406506 creator A5027463348 @default.
• W2920406506 creator A5031564392 @default.
• W2920406506 creator A5039579465 @default.
• W2920406506 creator A5049882309 @default.
• W2920406506 creator A5050887292 @default.
• W2920406506 creator A5058539752 @default.
• W2920406506 creator A5085347094 @default.
• W2920406506 creator A5090219433 @default.
• W2920406506 date "2019-03-01" @default.
• W2920406506 modified "2023-10-17" @default.
• W2920406506 title "Liver-derived fibroblast growth factor 21 mediates effects of glucagon-like peptide-1 in attenuating hepatic glucose output" @default.
• W2920406506 cites W1509966862 @default.
• W2920406506 cites W1554082053 @default.
• W2920406506 cites W1758370979 @default.
• W2920406506 cites W1877152454 @default.
• W2920406506 cites W1942040918 @default.
• W2920406506 cites W1968002849 @default.
• W2920406506 cites W1968925787 @default.
• W2920406506 cites W1973489602 @default.
• W2920406506 cites W1977119153 @default.
• W2920406506 cites W1977516373 @default.
• W2920406506 cites W1981183973 @default.
• W2920406506 cites W1984740259 @default.
• W2920406506 cites W1986085856 @default.
• W2920406506 cites W1988857777 @default.
• W2920406506 cites W1989584881 @default.
• W2920406506 cites W1992116679 @default.
• W2920406506 cites W1993235686 @default.
• W2920406506 cites W1993624198 @default.
• W2920406506 cites W1999938411 @default.
• W2920406506 cites W2004424892 @default.
• W2920406506 cites W2004836557 @default.
• W2920406506 cites W2012392098 @default.
• W2920406506 cites W2038335142 @default.
• W2920406506 cites W2047726905 @default.
• W2920406506 cites W2048975186 @default.
• W2920406506 cites W2074869995 @default.
• W2920406506 cites W2075514437 @default.
• W2920406506 cites W2080785707 @default.
• W2920406506 cites W2084948079 @default.
• W2920406506 cites W2087340989 @default.
• W2920406506 cites W2098435874 @default.
• W2920406506 cites W2100433915 @default.
• W2920406506 cites W2109071746 @default.
• W2920406506 cites W2114650931 @default.
• W2920406506 cites W2116286254 @default.
• W2920406506 cites W2119351413 @default.
• W2920406506 cites W2121049950 @default.
• W2920406506 cites W2125769789 @default.
• W2920406506 cites W2127046928 @default.
• W2920406506 cites W2129631252 @default.
• W2920406506 cites W2134944069 @default.
• W2920406506 cites W2139881904 @default.
• W2920406506 cites W2141362365 @default.
• W2920406506 cites W2143014102 @default.
• W2920406506 cites W2147029239 @default.
• W2920406506 cites W2150237271 @default.
• W2920406506 cites W2153152770 @default.
• W2920406506 cites W2155391879 @default.
• W2920406506 cites W2158342810 @default.
• W2920406506 cites W2159205789 @default.
• W2920406506 cites W2161407981 @default.
• W2920406506 cites W2162934281 @default.
• W2920406506 cites W2296260051 @default.
• W2920406506 cites W2306319461 @default.
• W2920406506 cites W2339053935 @default.
• W2920406506 cites W2389974717 @default.
• W2920406506 cites W2425644022 @default.
• W2920406506 cites W2516535870 @default.
• W2920406506 cites W2561274033 @default.
• W2920406506 cites W2566078452 @default.
• W2920406506 cites W2568036976 @default.
• W2920406506 cites W2583152045 @default.
• W2920406506 cites W2788921071 @default.
• W2920406506 doi "https://doi.org/10.1016/j.ebiom.2019.02.037" @default.
• W2920406506 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6443026" @default.
• W2920406506 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30827929" @default.
• W2920406506 hasPublicationYear "2019" @default.
• W2920406506 type Work @default.
• W2920406506 sameAs 2920406506 @default.
• W2920406506 citedByCount "36" @default.
• W2920406506 countsByYear W29204065062019 @default.
• W2920406506 countsByYear W29204065062020 @default.
• W2920406506 countsByYear W29204065062021 @default.
• W2920406506 countsByYear W29204065062022 @default.
• W2920406506 countsByYear W29204065062023 @default.
• W2920406506 crossrefType "journal-article" @default.
• W2920406506 hasAuthorship W2920406506A5006301048 @default.
• W2920406506 hasAuthorship W2920406506A5016812789 @default.
• W2920406506 hasAuthorship W2920406506A5019872937 @default.
• W2920406506 hasAuthorship W2920406506A5025015130 @default.
• W2920406506 hasAuthorship W2920406506A5027463348 @default.

• next