Matches in SemOpenAlex for { <https://semopenalex.org/work/W2920439197> ?p ?o ?g. }
- W2920439197 abstract "New neurons are continuously generated from stem cells and integrated into the adult hippocampal circuitry, contributing to memory function. Several environmental, cellular, and molecular factors regulate the formation of new neurons, but the mechanisms that govern their incorporation into memory circuits are less explored. Herein we will focus on microglia, the resident immune cells of the CNS, which modulate the production of new neurons in the adult hippocampus and are also well suited to participate in their circuit integration. Microglia may contribute to the refinement of brain circuits during development and exert a role in physiological and pathological conditions by regulating axonal and dendritic growth; promoting the formation, elimination, and relocation of synapses; modulating excitatory synaptic maturation; and participating in functional synaptic plasticity. Importantly, microglia are able to sense subtle changes in their environment and may use this information to differently modulate hippocampal wiring, ultimately impacting on memory function. Deciphering the role of microglia in hippocampal circuitry constant rewiring will help to better understand the influence of microglia on memory function." @default.
- W2920439197 created "2019-03-11" @default.
- W2920439197 creator A5065233553 @default.
- W2920439197 creator A5073129412 @default.
- W2920439197 creator A5078083717 @default.
- W2920439197 date "2019-03-05" @default.
- W2920439197 modified "2023-10-12" @default.
- W2920439197 title "Rewiring of Memory Circuits: Connecting Adult Newborn Neurons With the Help of Microglia" @default.
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