FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2920494534> ?p ?o ?g. }

• W2920494534 endingPage "111" @default.
• W2920494534 startingPage "106" @default.
• W2920494534 abstract "Leucine rich-repeat kinase 2 (LRRK2) is involved in the pathogenesis of Parkinson’s disease (PD). LRRK2 has kinase and GTPase activities, and mediates several cell functions, including vesicle trafficking, apoptosis, autophagy, mitochondrial dynamics, and neuroinflammation. G2019S (GS) is the most prevalent mutation of LRRK2. The mutation increases kinase activity, suggesting that this activity is crucial for PD pathogenesis. The activation and inhibition of LRRK2 kinase increases and reduces the levels of proinflammatory cytokines, respectively suggesting that the role of LRRK2 in neuroinflammation is critical for the pathology of PD. Previously, we demonstrated that microglial activation by lipopolysaccharide (LPS) increases mitochondrial fission via the activation of LRRK2 kinase, while LRRK2 kinase inhibition diminishes the fission morphology and release of tumor necrosis factor-alpha (TNFα) in BV2 or rat primary microglia and the brains of GS transgenic mice. In this study, the ectopic expression of GS LRRK2 in BV2 cells significantly elevated the expression of Drp1 along the fragmented mitochondria and decreased mitochondria size compared with controls. GS LRRK2-transfected BV2 cells displayed significantly increased TNFα release and neuronal death. Inhibition of LRRK2 kinase alleviated these features. TNFα levels in brains of GS mice were significantly increased compared to those in their littermates. These data further support our previous findings concerning LPS-induced neuroinflammation and mitochondrial fission in microglia via LRRK2 kinase activation." @default.
• W2920494534 created "2019-03-11" @default.
• W2920494534 creator A5035768302 @default.
• W2920494534 creator A5075407599 @default.
• W2920494534 creator A5081584954 @default.
• W2920494534 creator A5086083933 @default.
• W2920494534 date "2019-03-01" @default.
• W2920494534 modified "2023-10-15" @default.
• W2920494534 title "G2019s LRRK2 promotes mitochondrial fission and increases TNFα-mediated neuroinflammation responses" @default.
• W2920494534 cites W1561611826 @default.
• W2920494534 cites W1706551824 @default.
• W2920494534 cites W1774334900 @default.
• W2920494534 cites W1974495821 @default.
• W2920494534 cites W1992365739 @default.
• W2920494534 cites W1993547586 @default.
• W2920494534 cites W1997163042 @default.
• W2920494534 cites W2002260194 @default.
• W2920494534 cites W2016912126 @default.
• W2920494534 cites W2017158686 @default.
• W2920494534 cites W2018003642 @default.
• W2920494534 cites W2042183116 @default.
• W2920494534 cites W2104947764 @default.
• W2920494534 cites W2113518091 @default.
• W2920494534 cites W2117667168 @default.
• W2920494534 cites W2127978123 @default.
• W2920494534 cites W2160484806 @default.
• W2920494534 cites W2166593844 @default.
• W2920494534 cites W2472252914 @default.
• W2920494534 cites W2558423871 @default.
• W2920494534 cites W2883212301 @default.
• W2920494534 cites W2888203729 @default.
• W2920494534 cites W2889922047 @default.
• W2920494534 doi "https://doi.org/10.1080/19768354.2019.1585948" @default.
• W2920494534 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6440522" @default.
• W2920494534 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30949397" @default.
• W2920494534 hasPublicationYear "2019" @default.
• W2920494534 type Work @default.
• W2920494534 sameAs 2920494534 @default.
• W2920494534 citedByCount "16" @default.
• W2920494534 countsByYear W29204945342019 @default.
• W2920494534 countsByYear W29204945342020 @default.
• W2920494534 countsByYear W29204945342021 @default.
• W2920494534 countsByYear W29204945342022 @default.
• W2920494534 countsByYear W29204945342023 @default.
• W2920494534 crossrefType "journal-article" @default.
• W2920494534 hasAuthorship W2920494534A5035768302 @default.
• W2920494534 hasAuthorship W2920494534A5075407599 @default.
• W2920494534 hasAuthorship W2920494534A5081584954 @default.
• W2920494534 hasAuthorship W2920494534A5086083933 @default.
• W2920494534 hasBestOaLocation W29204945341 @default.
• W2920494534 hasConcept C104317684 @default.
• W2920494534 hasConcept C153911025 @default.
• W2920494534 hasConcept C164027704 @default.
• W2920494534 hasConcept C17619807 @default.
• W2920494534 hasConcept C17991360 @default.
• W2920494534 hasConcept C184235292 @default.
• W2920494534 hasConcept C203014093 @default.
• W2920494534 hasConcept C2776914184 @default.
• W2920494534 hasConcept C2779830541 @default.
• W2920494534 hasConcept C2780427247 @default.
• W2920494534 hasConcept C28859421 @default.
• W2920494534 hasConcept C501734568 @default.
• W2920494534 hasConcept C55493867 @default.
• W2920494534 hasConcept C86803240 @default.
• W2920494534 hasConcept C87753298 @default.
• W2920494534 hasConcept C95444343 @default.
• W2920494534 hasConceptScore W2920494534C104317684 @default.
• W2920494534 hasConceptScore W2920494534C153911025 @default.
• W2920494534 hasConceptScore W2920494534C164027704 @default.
• W2920494534 hasConceptScore W2920494534C17619807 @default.
• W2920494534 hasConceptScore W2920494534C17991360 @default.
• W2920494534 hasConceptScore W2920494534C184235292 @default.
• W2920494534 hasConceptScore W2920494534C203014093 @default.
• W2920494534 hasConceptScore W2920494534C2776914184 @default.
• W2920494534 hasConceptScore W2920494534C2779830541 @default.
• W2920494534 hasConceptScore W2920494534C2780427247 @default.
• W2920494534 hasConceptScore W2920494534C28859421 @default.
• W2920494534 hasConceptScore W2920494534C501734568 @default.
• W2920494534 hasConceptScore W2920494534C55493867 @default.
• W2920494534 hasConceptScore W2920494534C86803240 @default.
• W2920494534 hasConceptScore W2920494534C87753298 @default.
• W2920494534 hasConceptScore W2920494534C95444343 @default.
• W2920494534 hasFunder F4320321310 @default.
• W2920494534 hasIssue "2" @default.
• W2920494534 hasLocation W29204945341 @default.
• W2920494534 hasLocation W29204945342 @default.
• W2920494534 hasLocation W29204945343 @default.
• W2920494534 hasLocation W29204945344 @default.
• W2920494534 hasOpenAccess W2920494534 @default.
• W2920494534 hasPrimaryLocation W29204945341 @default.
• W2920494534 hasRelatedWork W1561611826 @default.
• W2920494534 hasRelatedWork W2297229933 @default.
• W2920494534 hasRelatedWork W2803817550 @default.
• W2920494534 hasRelatedWork W2804482952 @default.
• W2920494534 hasRelatedWork W2965172925 @default.
• W2920494534 hasRelatedWork W3107395714 @default.
• W2920494534 hasRelatedWork W4210963704 @default.
• W2920494534 hasRelatedWork W4281290245 @default.

• next