FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2920497807> ?p ?o ?g. }

• W2920497807 endingPage "625" @default.
• W2920497807 startingPage "619" @default.
• W2920497807 abstract "The abnormal expression of microRNAs (miRNAs) contributes to the development and progression of cancer. Recent studies have reported that miRNA-520e (miR-520e) is dysregulated in multiple cancers and is associated with tumor progression. However, the role of miR-520e in glioma has not been fully investigated. In this study, we investigated the function of miR-520e and its regulation by a molecular mechanism in gliomas. Our results showed that miR-520e expression was significantly downregulated in glioma tissues and cell lines. The overexpression of miR-520e repressed the proliferation, colony formation, and invasive potential of glioma cells, while the inhibition of miR-520e showed the opposite effect. The oncogenic gene fibroblast growth factor 19 (FGF19) was identified as a downstream target gene of miR-520e. The knockdown of FGF19 restricted the proliferation and invasion of glioma cells. Moreover, FGF19 knockdown or miR-520e overexpression decreased the expression of β-catenin and suppressed the transcriptional activity of Wnt/β-catenin signaling. Notably, the restoration of FGF19 expression partially reversed the miR-520e-mediated antitumor effect. In conclusion, our results demonstrate that miR-520e restricts the proliferation and invasion of glioma cells through the downregulation of FGF19/Wnt/β-catenin signaling, highlighting an importance of miR-520e/FGF19/Wnt/β-catenin signaling in gliomagenesis and suggesting miR-520e as a potential therapeutic target for gliomas." @default.
• W2920497807 created "2019-03-11" @default.
• W2920497807 creator A5066599847 @default.
• W2920497807 creator A5066828397 @default.
• W2920497807 creator A5069098559 @default.
• W2920497807 creator A5079873709 @default.
• W2920497807 date "2019-04-01" @default.
• W2920497807 modified "2023-10-18" @default.
• W2920497807 title "MicroRNA-520e restricts the proliferation and invasion of glioma cells through the downregulation of Wnt/β-catenin signaling by targeting fibroblast growth factor 19" @default.
• W2920497807 cites W1524819323 @default.
• W2920497807 cites W1539520316 @default.
• W2920497807 cites W1648301895 @default.
• W2920497807 cites W1935995766 @default.
• W2920497807 cites W1972645639 @default.
• W2920497807 cites W1975437957 @default.
• W2920497807 cites W1985121353 @default.
• W2920497807 cites W1988927152 @default.
• W2920497807 cites W2002408371 @default.
• W2920497807 cites W2002995168 @default.
• W2920497807 cites W2018441617 @default.
• W2920497807 cites W2027239974 @default.
• W2920497807 cites W2031236987 @default.
• W2920497807 cites W2034198983 @default.
• W2920497807 cites W2036044314 @default.
• W2920497807 cites W2042055907 @default.
• W2920497807 cites W2050633433 @default.
• W2920497807 cites W2060033322 @default.
• W2920497807 cites W2063746351 @default.
• W2920497807 cites W2119765426 @default.
• W2920497807 cites W2130220620 @default.
• W2920497807 cites W2131388056 @default.
• W2920497807 cites W2134807618 @default.
• W2920497807 cites W2136278188 @default.
• W2920497807 cites W2148337676 @default.
• W2920497807 cites W2153997364 @default.
• W2920497807 cites W2209465445 @default.
• W2920497807 cites W2334254977 @default.
• W2920497807 cites W2338827943 @default.
• W2920497807 cites W2515593787 @default.
• W2920497807 cites W2594877844 @default.
• W2920497807 cites W2747985210 @default.
• W2920497807 cites W2754439206 @default.
• W2920497807 cites W2806655879 @default.
• W2920497807 cites W2885505553 @default.
• W2920497807 cites W2887772201 @default.
• W2920497807 cites W2897223556 @default.
• W2920497807 cites W32883903 @default.
• W2920497807 doi "https://doi.org/10.1016/j.bbrc.2019.02.112" @default.
• W2920497807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30826062" @default.
• W2920497807 hasPublicationYear "2019" @default.
• W2920497807 type Work @default.
• W2920497807 sameAs 2920497807 @default.
• W2920497807 citedByCount "3" @default.
• W2920497807 countsByYear W29204978072019 @default.
• W2920497807 countsByYear W29204978072020 @default.
• W2920497807 crossrefType "journal-article" @default.
• W2920497807 hasAuthorship W2920497807A5066599847 @default.
• W2920497807 hasAuthorship W2920497807A5066828397 @default.
• W2920497807 hasAuthorship W2920497807A5069098559 @default.
• W2920497807 hasAuthorship W2920497807A5079873709 @default.
• W2920497807 hasConcept C104317684 @default.
• W2920497807 hasConcept C121608353 @default.
• W2920497807 hasConcept C127561419 @default.
• W2920497807 hasConcept C137620995 @default.
• W2920497807 hasConcept C145059251 @default.
• W2920497807 hasConcept C170493617 @default.
• W2920497807 hasConcept C173396325 @default.
• W2920497807 hasConcept C2778227246 @default.
• W2920497807 hasConcept C2779256057 @default.
• W2920497807 hasConcept C30145163 @default.
• W2920497807 hasConcept C502942594 @default.
• W2920497807 hasConcept C54355233 @default.
• W2920497807 hasConcept C62112901 @default.
• W2920497807 hasConcept C62478195 @default.
• W2920497807 hasConcept C74373430 @default.
• W2920497807 hasConcept C81885089 @default.
• W2920497807 hasConcept C86803240 @default.
• W2920497807 hasConcept C95444343 @default.
• W2920497807 hasConceptScore W2920497807C104317684 @default.
• W2920497807 hasConceptScore W2920497807C121608353 @default.
• W2920497807 hasConceptScore W2920497807C127561419 @default.
• W2920497807 hasConceptScore W2920497807C137620995 @default.
• W2920497807 hasConceptScore W2920497807C145059251 @default.
• W2920497807 hasConceptScore W2920497807C170493617 @default.
• W2920497807 hasConceptScore W2920497807C173396325 @default.
• W2920497807 hasConceptScore W2920497807C2778227246 @default.
• W2920497807 hasConceptScore W2920497807C2779256057 @default.
• W2920497807 hasConceptScore W2920497807C30145163 @default.
• W2920497807 hasConceptScore W2920497807C502942594 @default.
• W2920497807 hasConceptScore W2920497807C54355233 @default.
• W2920497807 hasConceptScore W2920497807C62112901 @default.
• W2920497807 hasConceptScore W2920497807C62478195 @default.
• W2920497807 hasConceptScore W2920497807C74373430 @default.
• W2920497807 hasConceptScore W2920497807C81885089 @default.
• W2920497807 hasConceptScore W2920497807C86803240 @default.
• W2920497807 hasConceptScore W2920497807C95444343 @default.
• W2920497807 hasIssue "3" @default.
• W2920497807 hasLocation W29204978071 @default.

• next