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• W2920587414 abstract "SOX9 is a key transcription factor during cell differentiation, sex determination, and tumorigenesis. However, the detailed mechanisms of its targeting strategy remain elusive. To investigate possibilities of targeting SOX9 with epigenetic drugs and the precise underlying mechanisms, two human cancer cell lines were chosen as model systems, which showed high SOX9 expression and anti-tumorigenic effects upon loss of SOX9. Histone acetylation-related screening of a small panel of epigenetic drugs revealed that the bromodomain reader inhibitor JQ1 dramatically downregulated SOX9 through multiple regulation steps, namely, transcription, BRD4-SOX9 protein-protein interaction, and further protein stability. These findings suggest that BRD4 inhibition is a novel therapeutic strategy for diseases characterized by SOX9 overexpression." @default.
• W2920587414 created "2019-03-11" @default.
• W2920587414 creator A5062081531 @default.
• W2920587414 creator A5088090136 @default.
• W2920587414 date "2019-04-01" @default.
• W2920587414 modified "2023-10-13" @default.
• W2920587414 title "SOX9 is controlled by the BRD4 inhibitor JQ1 via multiple regulation mechanisms" @default.
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• W2920587414 doi "https://doi.org/10.1016/j.bbrc.2019.02.135" @default.
• W2920587414 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30833074" @default.
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