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- W2920762928 endingPage "238" @default.
- W2920762928 startingPage "191" @default.
- W2920762928 abstract "Organohalide respiration (OHR) is an anaerobic metabolism by which bacteria conserve energy with the use of halogenated compounds as terminal electron acceptors. Genes involved in OHR are organized in reductive dehalogenase (rdh) gene clusters and can be found in relatively high copy numbers in the genomes of organohalide-respiring bacteria (OHRB). The minimal rdh gene set is composed by rdhA and rdhB, encoding the catalytic enzyme involved in reductive dehalogenation and its putative membrane anchor, respectively. In this chapter, we present the major findings concerning the regulatory strategies developed by OHRB to control the expression of the rdh gene clusters. The first section focuses on the description of regulation patterns obtained from targeted transcriptional analyses, and from transcriptomic and proteomic studies, while the second section offers a detailed overview of the biochemically characterized OHR regulatory proteins identified so far. Depending on OHRB, transcriptional regulators belonging to three different protein families are found in the direct vicinity of rdh gene clusters, suggesting that they activate the transcription of their cognate gene cluster. In this chapter, strong emphasis was laid on the family of CRP/FNR-type RdhK regulators which belong to members of the genera Dehalobacter and Desulfitobacterium. Whereas only chlorophenols have been identified as effectors for RdhK regulators, the protein sequence diversity suggests a broader organohalide spectrum. Thus, effector identification of new regulators offers a promising alternative to elucidate the substrates of yet uncharacterized reductive dehalogenases. Future work investigating the possible cross-talk between OHR regulators and their possible use as biosensors is discussed." @default.
- W2920762928 created "2019-03-11" @default.
- W2920762928 creator A5045555604 @default.
- W2920762928 creator A5055787416 @default.
- W2920762928 date "2019-01-01" @default.
- W2920762928 modified "2023-10-14" @default.
- W2920762928 title "Regulation of organohalide respiration" @default.
- W2920762928 cites W1554496134 @default.
- W2920762928 cites W1589237644 @default.
- W2920762928 cites W1933628209 @default.
- W2920762928 cites W1953614311 @default.
- W2920762928 cites W1965530140 @default.
- W2920762928 cites W1967148090 @default.
- W2920762928 cites W1972627065 @default.
- W2920762928 cites W1973394058 @default.
- W2920762928 cites W1978101440 @default.
- W2920762928 cites W1978495127 @default.
- W2920762928 cites W1980549909 @default.
- W2920762928 cites W1982573344 @default.
- W2920762928 cites W1983081312 @default.
- W2920762928 cites W1983732363 @default.
- W2920762928 cites W1986362483 @default.
- W2920762928 cites W1988202385 @default.
- W2920762928 cites W1989488774 @default.
- W2920762928 cites W1998185450 @default.
- W2920762928 cites W1998584284 @default.
- W2920762928 cites W2001138725 @default.
- W2920762928 cites W2004709539 @default.
- W2920762928 cites W2004964177 @default.
- W2920762928 cites W2005372695 @default.
- W2920762928 cites W2011649527 @default.
- W2920762928 cites W2013759011 @default.
- W2920762928 cites W2014434187 @default.
- W2920762928 cites W2017346525 @default.
- W2920762928 cites W2018710872 @default.
- W2920762928 cites W2020894519 @default.
- W2920762928 cites W2022044168 @default.
- W2920762928 cites W2024444267 @default.
- W2920762928 cites W2027107068 @default.
- W2920762928 cites W2028290247 @default.
- W2920762928 cites W2038269688 @default.
- W2920762928 cites W2043104148 @default.
- W2920762928 cites W2047625159 @default.
- W2920762928 cites W2047919169 @default.
- W2920762928 cites W2049752350 @default.
- W2920762928 cites W2060363542 @default.
- W2920762928 cites W2063186565 @default.
- W2920762928 cites W2068315188 @default.
- W2920762928 cites W2069184191 @default.
- W2920762928 cites W2069463037 @default.
- W2920762928 cites W2069968267 @default.
- W2920762928 cites W2070303673 @default.
- W2920762928 cites W2072656551 @default.
- W2920762928 cites W2074870692 @default.
- W2920762928 cites W2075155653 @default.
- W2920762928 cites W2075704290 @default.
- W2920762928 cites W2076195226 @default.
- W2920762928 cites W2079471172 @default.
- W2920762928 cites W2079593308 @default.
- W2920762928 cites W2080688660 @default.
- W2920762928 cites W2080900730 @default.
- W2920762928 cites W2087753842 @default.
- W2920762928 cites W2088733965 @default.
- W2920762928 cites W2091982285 @default.
- W2920762928 cites W2092906794 @default.
- W2920762928 cites W2093548226 @default.
- W2920762928 cites W2094409086 @default.
- W2920762928 cites W2097302754 @default.
- W2920762928 cites W2097305047 @default.
- W2920762928 cites W2100314338 @default.
- W2920762928 cites W2108195866 @default.
- W2920762928 cites W2109758481 @default.
- W2920762928 cites W2110745394 @default.
- W2920762928 cites W2111325483 @default.
- W2920762928 cites W2111327072 @default.
- W2920762928 cites W2112792797 @default.
- W2920762928 cites W2113612523 @default.
- W2920762928 cites W2114772522 @default.
- W2920762928 cites W2115400034 @default.
- W2920762928 cites W2115871010 @default.
- W2920762928 cites W2115906498 @default.
- W2920762928 cites W2116275086 @default.
- W2920762928 cites W2120344776 @default.
- W2920762928 cites W2123615589 @default.
- W2920762928 cites W2125112034 @default.
- W2920762928 cites W2125657224 @default.
- W2920762928 cites W2126818765 @default.
- W2920762928 cites W2129119088 @default.
- W2920762928 cites W2130360100 @default.
- W2920762928 cites W2131189533 @default.
- W2920762928 cites W2134201593 @default.
- W2920762928 cites W2137015675 @default.
- W2920762928 cites W2139173441 @default.
- W2920762928 cites W2140118240 @default.
- W2920762928 cites W2141606648 @default.
- W2920762928 cites W2144627731 @default.
- W2920762928 cites W2146580387 @default.
- W2920762928 cites W2147196205 @default.