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- W2920781373 abstract "The major cause of hereditary blindness in North America is retinitis pigmentosa (RP), which is a group of inherited retinal diseases characterized by the onset of night blindness, early loss of peripheral vision, and late loss of central vision. Most cases of RP are caused by mutations in rod-specific genes resulting in the demise of rod photoreceptors. However, the subsequent loss of cone photoreceptor function remained a mystery until the recent observation that glucose starvation of cones occurs because of the entrapment of glucose in RPE following the onset of rod outer segment (ROS) degeneration. Reversal of glucose starvation of cones represents a potential therapeutic intervention that would be of great benefit to patients regardless of the genetic mutation in rods responsible for RP." @default.
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- W2920781373 date "2019-01-01" @default.
- W2920781373 modified "2023-09-25" @default.
- W2920781373 title "Restoration of Cone Photoreceptor Function in Retinitis Pigmentosa (RP): Retinal Cell-Based Therapy" @default.
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- W2920781373 doi "https://doi.org/10.1007/978-3-030-05222-5_9" @default.
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