FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2920781391> ?p ?o ?g. }

• W2920781391 abstract "Abstract Offspring of mothers with hyperglycemia during pregnancy have a higher incidence of long-term neuropsychiatric disorders than offspring from a normal pregnancy, indicating that neocortical neurogenesis might be affected by maternal hyperglycemia. A paucity of study evaluating the effects of hyperglycemia on neocortical neurogenetic differentiation of neural stem cells, and the mechanism remains unclear. We sought to investigate the the roles and possible molecular mechanism of maternal hyperglycemia on neocortical neurogenetic differentiation of neural stem cells. We established a mouse model of a hyperglycemic pregnancy to study effects of intrauterine exposure to maternal hyperglycemia on neocortical neurogenesis. We observed morphological changes in the neocortex and detected the neurogenetic differentiation of neural stem cells in offspring affected by high glucose levels. We investigated the regulatory network between epigenetic modification and transcription factors in differentiated neural stem cells under hyperglycemic conditions. Maternal hyperglycemia disturbs neocortical lamination in some non-malformed offspring. Our results suggested that hyperglycemia altered the early-born neuron fate and the distribution of newborn neurons in deep layers by promoting the earlier differentiation of neural stem cells. Altered histone acetylation and its regulation on the transcription of proneural genes might be correlated to the disrupted differentiation of neural stem cells and altered distribution of newborn projection neurons in the neocortex. Our data raised the possibility that maternal hyperglycemia in pregnancy disturbs the laminar distribution of neocortical projection neurons in some non-malformed offspring via epigenetic regulation on neural stem cell differentiation and the birthdate of neocortical neurons." @default.
• W2920781391 created "2019-03-11" @default.
• W2920781391 creator A5004260318 @default.
• W2920781391 creator A5004957511 @default.
• W2920781391 creator A5013654875 @default.
• W2920781391 creator A5024541563 @default.
• W2920781391 creator A5029586830 @default.
• W2920781391 creator A5043927577 @default.
• W2920781391 creator A5055205314 @default.
• W2920781391 creator A5068074713 @default.
• W2920781391 creator A5070760631 @default.
• W2920781391 creator A5086948762 @default.
• W2920781391 date "2019-03-01" @default.
• W2920781391 modified "2023-10-12" @default.
• W2920781391 title "Maternal hyperglycemia disturbs neocortical neurogenesis via epigenetic regulation in C57BL/6J mice" @default.
• W2920781391 cites W118818797 @default.
• W2920781391 cites W1639109957 @default.
• W2920781391 cites W1692786758 @default.
• W2920781391 cites W1778792730 @default.
• W2920781391 cites W1885149309 @default.
• W2920781391 cites W1912023046 @default.
• W2920781391 cites W1921704775 @default.
• W2920781391 cites W1966900376 @default.
• W2920781391 cites W1986048260 @default.
• W2920781391 cites W1989164058 @default.
• W2920781391 cites W1989591246 @default.
• W2920781391 cites W1990510025 @default.
• W2920781391 cites W1999846090 @default.
• W2920781391 cites W2000177129 @default.
• W2920781391 cites W2002698073 @default.
• W2920781391 cites W2006718746 @default.
• W2920781391 cites W2007835245 @default.
• W2920781391 cites W2008919101 @default.
• W2920781391 cites W2010459589 @default.
• W2920781391 cites W2015964634 @default.
• W2920781391 cites W2026128535 @default.
• W2920781391 cites W2040900733 @default.
• W2920781391 cites W2048163917 @default.
• W2920781391 cites W2050106804 @default.
• W2920781391 cites W2052572393 @default.
• W2920781391 cites W2062809474 @default.
• W2920781391 cites W2063231976 @default.
• W2920781391 cites W2063790483 @default.
• W2920781391 cites W2069709375 @default.
• W2920781391 cites W2072982367 @default.
• W2920781391 cites W2084408643 @default.
• W2920781391 cites W2085256528 @default.
• W2920781391 cites W2085826958 @default.
• W2920781391 cites W2086308437 @default.
• W2920781391 cites W2086505658 @default.
• W2920781391 cites W2092639362 @default.
• W2920781391 cites W2093654293 @default.
• W2920781391 cites W2095296561 @default.
• W2920781391 cites W2097725455 @default.
• W2920781391 cites W2099642308 @default.
• W2920781391 cites W2107056468 @default.
• W2920781391 cites W2108932086 @default.
• W2920781391 cites W2117317524 @default.
• W2920781391 cites W2120504963 @default.
• W2920781391 cites W2126486896 @default.
• W2920781391 cites W2127136880 @default.
• W2920781391 cites W2131905274 @default.
• W2920781391 cites W2131998216 @default.
• W2920781391 cites W2132053987 @default.
• W2920781391 cites W2133446394 @default.
• W2920781391 cites W2137155763 @default.
• W2920781391 cites W2138948174 @default.
• W2920781391 cites W2142695196 @default.
• W2920781391 cites W2151718948 @default.
• W2920781391 cites W2164821316 @default.
• W2920781391 cites W2171774073 @default.
• W2920781391 cites W2202302713 @default.
• W2920781391 cites W2277544136 @default.
• W2920781391 cites W2292671099 @default.
• W2920781391 cites W2338198207 @default.
• W2920781391 cites W2338530425 @default.
• W2920781391 cites W2535607091 @default.
• W2920781391 cites W2740957747 @default.
• W2920781391 cites W2754006628 @default.
• W2920781391 doi "https://doi.org/10.1038/s41419-019-1438-z" @default.
• W2920781391 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6397163" @default.
• W2920781391 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30824686" @default.
• W2920781391 hasPublicationYear "2019" @default.
• W2920781391 type Work @default.
• W2920781391 sameAs 2920781391 @default.
• W2920781391 citedByCount "14" @default.
• W2920781391 countsByYear W29207813912020 @default.
• W2920781391 countsByYear W29207813912021 @default.
• W2920781391 countsByYear W29207813912022 @default.
• W2920781391 countsByYear W29207813912023 @default.
• W2920781391 crossrefType "journal-article" @default.
• W2920781391 hasAuthorship W2920781391A5004260318 @default.
• W2920781391 hasAuthorship W2920781391A5004957511 @default.
• W2920781391 hasAuthorship W2920781391A5013654875 @default.
• W2920781391 hasAuthorship W2920781391A5024541563 @default.
• W2920781391 hasAuthorship W2920781391A5029586830 @default.
• W2920781391 hasAuthorship W2920781391A5043927577 @default.
• W2920781391 hasAuthorship W2920781391A5055205314 @default.
• W2920781391 hasAuthorship W2920781391A5068074713 @default.
• W2920781391 hasAuthorship W2920781391A5070760631 @default.

• next