Matches in SemOpenAlex for { <https://semopenalex.org/work/W2920792857> ?p ?o ?g. }
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- W2920792857 abstract "Among the diverse interneuron subtypes in the neocortex, chandelier cells (ChCs) are the only population that selectively innervate pyramidal neurons (PyNs) at their axon initial segment (AIS), the site of action potential initiation, allowing them to exert powerful control over PyN output. Yet, mechanisms underlying their subcellular innervation of PyN AISs are unknown. To identify molecular determinants of ChC/PyN AIS innervation, we performed an in vivo RNAi screen of PyN-expressed axonal cell adhesion molecules (CAMs) and select Ephs/ephrins. Strikingly, we found the L1 family member L1CAM to be the only molecule required for ChC/PyN AIS innervation. Further, we show that L1CAM is required during both the establishment and maintenance of innervation, and that selective innervation of PyN AISs by ChCs requires AIS anchoring of L1CAM by the cytoskeletal ankyrin-G/βIV-spectrin complex. Thus, our findings identify PyN-expressed L1CAM as a critical CAM required for innervation of neocortical PyN AISs by ChCs.Video AbstracteyJraWQiOiI4ZjUxYWNhY2IzYjhiNjNlNzFlYmIzYWFmYTU5NmZmYyIsImFsZyI6IlJTMjU2In0.eyJzdWIiOiI1NWQwZTlhMDg1ZjUzZDc1M2QxM2IwY2FhZThlYzZkYSIsImtpZCI6IjhmNTFhY2FjYjNiOGI2M2U3MWViYjNhYWZhNTk2ZmZjIiwiZXhwIjoxNjc4Nzc1MjExfQ.QaGJhWx4T4uVNmlBFy978v8ALcK26wtP5Bag44qRdI_AMBdPpc0CwjOfB6l956uuuzeLnzvt8_IAovNtB8_Rii4_ILTIW8jaEewC1capz-HNvTutgDiz7Rpp4OPX0o7da8YYJDSnSN7D-141OdQ2AsD8GZqjl1tUhk2bPpEayr9xG_l1CouWgxU4CVgLZ5kiKluTP9p3jvWY7ZfaCnGLgECQ7WsssEwnMwUT4M7-AxSPGD3sle7n14ikS4YmXYD5B-Gjs1HEE79Ru7rh9Pfh5Wcp7F7x2W8i4W74zrY2rotF0g10RfaDFsm0ykkqvAAJpo6xv--WcuElGng2g1WhKQ(mp4, (46.17 MB) Download video" @default.
- W2920792857 created "2019-03-11" @default.
- W2920792857 creator A5036647389 @default.
- W2920792857 creator A5054326054 @default.
- W2920792857 creator A5054938864 @default.
- W2920792857 creator A5055032477 @default.
- W2920792857 creator A5072827834 @default.
- W2920792857 date "2019-04-01" @default.
- W2920792857 modified "2023-10-16" @default.
- W2920792857 title "Axo-axonic Innervation of Neocortical Pyramidal Neurons by GABAergic Chandelier Cells Requires AnkyrinG-Associated L1CAM" @default.
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- W2920792857 doi "https://doi.org/10.1016/j.neuron.2019.02.009" @default.
- W2920792857 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6525570" @default.