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- W2920797095 abstract "Evidence supports an inverse association between vitamin D and bacterial vaginosis (BV) during pregnancy. Furthermore, both the vaginal microbiome and vitamin D status correlate with pregnancy outcome. Women of African ancestry are more likely to experience BV, to be vitamin D deficient, and to have certain pregnancy complications. We investigated the association between vitamin D status and the vaginal microbiome.Subjects were assigned to a treatment (4400 IU) or a control group (400 IU vitamin D daily), sampled three times during pregnancy, and vaginal 16S rRNA gene taxonomic profiles and plasma 25-hydroxyvitamin D [25(OH)D] concentrations were examined.Gestational age and ethnicity were significantly associated with the microbiome. Megasphaera correlated negatively (p = 0.0187) with 25(OH)D among women of African ancestry. Among controls, women of European ancestry exhibited a positive correlation between plasma 25(OH)D and L. crispatus abundance.Certain vaginal bacteria are associated with plasma 25(OH)D concentration." @default.
- W2920797095 created "2019-03-22" @default.
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- W2920797095 date "2019-03-11" @default.
- W2920797095 modified "2023-10-12" @default.
- W2920797095 title "Relationship between vitamin D status and the vaginal microbiome during pregnancy" @default.
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- W2920797095 doi "https://doi.org/10.1038/s41372-019-0343-8" @default.
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