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- W2920797671 abstract "Cancer currently stands as the second-leading cause of death worldwide. Studies reveal colorectal cancer (CRC) to be the 4 th leading cause of mortality due to cancer. It is estimated that about 30% of CRC cases are hereditary, of which 5% are attributed by known syndromes, particularly Lynch Syndrome. This pilot study aims to fabricate a DNA-graphene-polypyrole (DGP) based biosensor to diagnose deficiency of functional MMR proteins present in patients at a scale of less than ng/ ml. We find that the interactive forces between avidin and graphene are mainly hydrophobic, along with some van der Waals, electrostatic and hydrogen bonding interactions. Notably, the structure and function of the avidin molecule is preserved after its adsorption on the graphene surface. Electrochemical impedance spectroscopy (EIS) analysis of avidin immobilized on a graphenated polypyrrole (G-PPy) conductive substrate, confirms adsorption of avidin on graphene nano platelets and corresponding changes in electrical impedance, respectively. EIS analysis of MutS substrate and MutS immobilized on GPPy chips confirmed the working of the bio sensor by corresponding change in electrical impedance. To support this real-world system, we have conducted simulation studies as well. In the simulation studies from 0-200na, we portray progression structures of human MutS protein to biotinylated DNA that has been fixed to simulate the process of a biosensor, furthermore the mismatch in the DNA has been manually introduced by means of computational tools to show to see the interaction of the DNA and the protein. This investigation additionally permits us in early detection of colorectal cancer and the mapping and understanding of the process associated with the location of the mismatch repair." @default.
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- W2920797671 date "2018-03-23" @default.
- W2920797671 modified "2023-09-22" @default.
- W2920797671 title "Graphene Patterned Microchip For Colorectal Cancer Detection" @default.
- W2920797671 hasPublicationYear "2018" @default.
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