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- W2920824725 abstract "Small cell lung cancer (SCLC) is a highly malignant disease with a dismal prognosis that is currently being tested for theclinical activity of checkpoint inhibitors. SCLC is associated with smoking and exhibits a high mutational burden. However, low expression of PD-L1 and MHC antigens, as well low levels of immune cell infiltration and rapid tumor progress seems to limit the efficacy of anticancer immunity. Nevertheless, long-term survival was reported from studies using anti-PD-1/PD-L1 and CTLA-4 agents.Data of clinical trials of checkpoint inhibitors in SCLC show lower success rates compared to NSCLC. The mechanisms of resistance to immunotherapy are discussed for their relevance to SCLC patients.Although some factors, such as a high mutation rate, favor immunotherapy for SCLC patients, downregulation of MHC class I, low expression of PD-L1, poor tumor infiltration by effector T cells, presence of myeloid-derived suppressor cells as well as regulatory T lymphocytes counteract the immune system activation by checkpoint inhibitors. Furthermore, this tumor develops avascular regions which have immunosuppressive effects and restrict access of lymphocytes and antibodies. In conclusion, immunotherapy in SCLC is effective in highly selected patients with good performance status and special and unknown preconditions contributing to long-lasting responses." @default.
- W2920824725 created "2019-03-22" @default.
- W2920824725 creator A5019973974 @default.
- W2920824725 creator A5052820511 @default.
- W2920824725 date "2019-03-18" @default.
- W2920824725 modified "2023-10-16" @default.
- W2920824725 title "Immunotherapy for small cell lung cancer: mechanisms of resistance" @default.
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- W2920824725 cites W1889335134 @default.
- W2920824725 cites W1903523058 @default.
- W2920824725 cites W1922412259 @default.
- W2920824725 cites W1923410233 @default.
- W2920824725 cites W1991396100 @default.
- W2920824725 cites W1994261231 @default.
- W2920824725 cites W2009720434 @default.
- W2920824725 cites W2030500811 @default.
- W2920824725 cites W2043261929 @default.
- W2920824725 cites W2045097625 @default.
- W2920824725 cites W2058264985 @default.
- W2920824725 cites W2062873927 @default.
- W2920824725 cites W2070841384 @default.
- W2920824725 cites W2095090692 @default.
- W2920824725 cites W2095690828 @default.
- W2920824725 cites W2103973613 @default.
- W2920824725 cites W2115094537 @default.
- W2920824725 cites W2131664752 @default.
- W2920824725 cites W2132518242 @default.
- W2920824725 cites W2139216037 @default.
- W2920824725 cites W2166447055 @default.
- W2920824725 cites W2168234885 @default.
- W2920824725 cites W2175875188 @default.
- W2920824725 cites W2179187436 @default.
- W2920824725 cites W2345952503 @default.
- W2920824725 cites W2407043630 @default.
- W2920824725 cites W2414258135 @default.
- W2920824725 cites W2418354692 @default.
- W2920824725 cites W2482957815 @default.
- W2920824725 cites W2512460219 @default.
- W2920824725 cites W2518538521 @default.
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- W2920824725 cites W2547187744 @default.
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- W2920824725 cites W2587048937 @default.
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- W2920824725 cites W2728472279 @default.
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- W2920824725 cites W2804102248 @default.
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- W2920824725 doi "https://doi.org/10.1080/14712598.2019.1592155" @default.
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