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- W2920841323 endingPage "1175" @default.
- W2920841323 startingPage "1170" @default.
- W2920841323 abstract "The past decade has witnessed a major increase in our understanding of the genetic underpinnings of childhood cancer. Genomic sequencing studies have highlighted key differences between pediatric and adult cancers. Whereas many adult cancers are characterized by a high number of somatic mutations, pediatric cancers typically have few somatic mutations but a higher prevalence of germline alterations in cancer predisposition genes. Also noteworthy is the remarkable heterogeneity in the types of genetic alterations that likely drive the growth of pediatric cancers, including copy number alterations, gene fusions, enhancer hijacking events, and chromoplexy. Because most studies have genetically profiled pediatric cancers only at diagnosis, the mechanisms underlying tumor progression, therapy resistance, and metastasis remain poorly understood. We discuss evidence that points to a need for more integrative approaches aimed at identifying driver events in pediatric cancers at both diagnosis and relapse. We also provide an overview of key aspects of germline predisposition for cancer in this age group." @default.
- W2920841323 created "2019-03-22" @default.
- W2920841323 creator A5023572421 @default.
- W2920841323 creator A5026362990 @default.
- W2920841323 date "2019-03-15" @default.
- W2920841323 modified "2023-10-12" @default.
- W2920841323 title "The genomic landscape of pediatric cancers: Implications for diagnosis and treatment" @default.
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- W2920841323 doi "https://doi.org/10.1126/science.aaw3535" @default.
- W2920841323 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7757338" @default.
- W2920841323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30872516" @default.
- W2920841323 hasPublicationYear "2019" @default.
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