FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2920844234> ?p ?o ?g. }

• W2920844234 abstract "Abstract Members of the Mycobacterium chelonae - abscessus complex (MCAC) are close to the mycobacterial ancestor and includes both human, animal and fish pathogens. We present the genomes of 14 members of this complex: the complete genomes of Mycobacterium salmoniphilum and Mycobacterium chelonae type strains, seven M. salmoniphilum isolates, and five M. salmoniphilum -like strains including strains isolated during an outbreak in an animal facility at Uppsala University. Average nucleotide identity (ANI) analysis and core gene phylogeny revealed that the M. salmoniphilum -like strains are variants of the human pathogen Mycobacterium franklinii and phylogenetically close to Mycobacterium abscessus . Our data further suggested that M. salmoniphilum separates into three branches named group I, II and III with the M. salmoniphilum type strain belonging to group II. Among predicted virulence factors, the presence of phospholipase C ( plcC ), which is a major virulence factor that makes M. abscessus highly cytotoxic to mouse macrophages, and that M. franklinii originally was isolated from infected humans make it plausible that the outbreak in the animal facility was caused by a M. salmoniphilum -like strain. Interestingly, M. salmoniphilum -like was isolated from tap water suggesting that it can be present in the environment. Moreover, we predicted the presence of mutational hotspots in the M. salmoniphilum isolates and 26% of these hotspots overlap with genes categorized as having roles in virulence, disease and defense. We also provide data about key genes involved in transcription and translation such as sigma factor, ribosomal protein and tRNA genes." @default.
• W2920844234 created "2019-03-22" @default.
• W2920844234 creator A5026752432 @default.
• W2920844234 creator A5030376046 @default.
• W2920844234 creator A5036103402 @default.
• W2920844234 creator A5037123805 @default.
• W2920844234 creator A5044013608 @default.
• W2920844234 creator A5061229122 @default.
• W2920844234 creator A5064067009 @default.
• W2920844234 creator A5079902178 @default.
• W2920844234 date "2019-03-14" @default.
• W2920844234 modified "2023-10-16" @default.
• W2920844234 title "Extended insight into the Mycobacterium chelonae-abscessus complex through whole genome sequencing of Mycobacterium salmoniphilum outbreak and Mycobacterium salmoniphilum-like strains" @default.
• W2920844234 cites W1535325794 @default.
• W2920844234 cites W1607802369 @default.
• W2920844234 cites W1670267633 @default.
• W2920844234 cites W1748664227 @default.
• W2920844234 cites W1872269975 @default.
• W2920844234 cites W1943865121 @default.
• W2920844234 cites W1958799813 @default.
• W2920844234 cites W1967912835 @default.
• W2920844234 cites W1969349373 @default.
• W2920844234 cites W1973827044 @default.
• W2920844234 cites W1979390490 @default.
• W2920844234 cites W1983403167 @default.
• W2920844234 cites W1987084454 @default.
• W2920844234 cites W1988561009 @default.
• W2920844234 cites W1989005071 @default.
• W2920844234 cites W1990426706 @default.
• W2920844234 cites W1991330646 @default.
• W2920844234 cites W1993124128 @default.
• W2920844234 cites W1997219104 @default.
• W2920844234 cites W1998258963 @default.
• W2920844234 cites W2000425923 @default.
• W2920844234 cites W2000898667 @default.
• W2920844234 cites W2004548026 @default.
• W2920844234 cites W2007604850 @default.
• W2920844234 cites W2020767338 @default.
• W2920844234 cites W2029249249 @default.
• W2920844234 cites W2035710039 @default.
• W2920844234 cites W2045843097 @default.
• W2920844234 cites W2050075759 @default.
• W2920844234 cites W2052426953 @default.
• W2920844234 cites W2057740405 @default.
• W2920844234 cites W2075061006 @default.
• W2920844234 cites W2075879801 @default.
• W2920844234 cites W2078868084 @default.
• W2920844234 cites W2096093282 @default.
• W2920844234 cites W2100363512 @default.
• W2920844234 cites W2101830136 @default.
• W2920844234 cites W2102229358 @default.
• W2920844234 cites W2103339684 @default.
• W2920844234 cites W2104308365 @default.
• W2920844234 cites W2105329815 @default.
• W2920844234 cites W2113068511 @default.
• W2920844234 cites W2116233885 @default.
• W2920844234 cites W2119888547 @default.
• W2920844234 cites W2121139063 @default.
• W2920844234 cites W2125391832 @default.
• W2920844234 cites W2126259938 @default.
• W2920844234 cites W2129267752 @default.
• W2920844234 cites W2134375163 @default.
• W2920844234 cites W2134948698 @default.
• W2920844234 cites W2136322092 @default.
• W2920844234 cites W2141115207 @default.
• W2920844234 cites W2141925611 @default.
• W2920844234 cites W2143191480 @default.
• W2920844234 cites W2145552072 @default.
• W2920844234 cites W2145767324 @default.
• W2920844234 cites W2152331922 @default.
• W2920844234 cites W2158023121 @default.
• W2920844234 cites W2166297468 @default.
• W2920844234 cites W2167621178 @default.
• W2920844234 cites W2211282329 @default.
• W2920844234 cites W2223993952 @default.
• W2920844234 cites W2277244975 @default.
• W2920844234 cites W2317876947 @default.
• W2920844234 cites W2328071476 @default.
• W2920844234 cites W2342145395 @default.
• W2920844234 cites W2431006159 @default.
• W2920844234 cites W2462915387 @default.
• W2920844234 cites W2474645827 @default.
• W2920844234 cites W2527411440 @default.
• W2920844234 cites W2535274628 @default.
• W2920844234 cites W2553168732 @default.
• W2920844234 cites W2556833369 @default.
• W2920844234 cites W2600736805 @default.
• W2920844234 cites W2611319530 @default.
• W2920844234 cites W2613213106 @default.
• W2920844234 cites W2620976278 @default.
• W2920844234 cites W2762985876 @default.
• W2920844234 cites W2783698286 @default.
• W2920844234 cites W2789948184 @default.
• W2920844234 cites W2791765621 @default.
• W2920844234 cites W2802044770 @default.
• W2920844234 cites W2950666031 @default.
• W2920844234 cites W365155413 @default.
• W2920844234 cites W4251026935 @default.
• W2920844234 doi "https://doi.org/10.1038/s41598-019-40922-x" @default.
• W2920844234 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6418233" @default.

• next