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• W2920854633 endingPage "592" @default.
• W2920854633 startingPage "578" @default.
• W2920854633 abstract "Mechanokinetic statistical models describe the mechanisms of muscle contraction on the basis of the average behavior of a large ensemble of actin–myosin motors. Such models often assume that myosin II motor domains bind to regularly spaced, discrete target zones along the actin-based thin filaments and develop force in a series of strain-dependent transitions under the turnover of ATP. The simplest models assume that there is just one myosin-binding site per target zone and a uniform spatial distribution of the myosin motor domains in relation to each site. However, most of the recently developed models assume three myosin-binding sites per target zone, and some models include a spatially explicit 3-D treatment of the myofilament lattice and thereby of the geometry of the actin–myosin contact points. Here, I show that the predictions for steady-state contractile behavior of muscle are very similar whether one or three myosin-binding sites per target zone is assumed, provided that the model responses are appropriately scaled to the number of sites. Comparison of the model predictions for isometrically contracting mammalian muscle cells suggests that each target zone contains three or more myosin-binding sites. Finally, I discuss the strengths and weaknesses of one-site spatially inexplicit models in relation to three-site models, including those that take into account the detailed 3-D geometry of the myofilament lattice. The results of this study suggest that single-site models, with reduced computational cost compared with multisite models, are useful for several purposes, e.g., facilitated molecular mechanistic insights." @default.
• W2920854633 created "2019-03-22" @default.
• W2920854633 creator A5003694914 @default.
• W2920854633 date "2019-03-14" @default.
• W2920854633 modified "2023-10-06" @default.
• W2920854633 title "Comparing models with one versus multiple myosin-binding sites per actin target zone: The power of simplicity" @default.
• W2920854633 cites W1263268564 @default.
• W2920854633 cites W1965337436 @default.
• W2920854633 cites W1972794896 @default.
• W2920854633 cites W1973038113 @default.
• W2920854633 cites W1974259657 @default.
• W2920854633 cites W1976053070 @default.
• W2920854633 cites W1976823045 @default.
• W2920854633 cites W1977609596 @default.
• W2920854633 cites W1983407178 @default.
• W2920854633 cites W1983877182 @default.
• W2920854633 cites W1984647013 @default.
• W2920854633 cites W1987181390 @default.
• W2920854633 cites W1992331713 @default.
• W2920854633 cites W1996422981 @default.
• W2920854633 cites W1998192455 @default.
• W2920854633 cites W2001056402 @default.
• W2920854633 cites W2006971654 @default.
• W2920854633 cites W2007099432 @default.
• W2920854633 cites W2008328509 @default.
• W2920854633 cites W2011855284 @default.
• W2920854633 cites W2014383313 @default.
• W2920854633 cites W2015389979 @default.
• W2920854633 cites W2016084904 @default.
• W2920854633 cites W2017488454 @default.
• W2920854633 cites W2019201408 @default.
• W2920854633 cites W2021903837 @default.
• W2920854633 cites W2025966513 @default.
• W2920854633 cites W2026145805 @default.
• W2920854633 cites W2031099832 @default.
• W2920854633 cites W2032127615 @default.
• W2920854633 cites W2036538240 @default.
• W2920854633 cites W2036574067 @default.
• W2920854633 cites W2046546582 @default.
• W2920854633 cites W2049674508 @default.
• W2920854633 cites W2050659206 @default.
• W2920854633 cites W2052192720 @default.
• W2920854633 cites W2056192324 @default.
• W2920854633 cites W2057046821 @default.
• W2920854633 cites W2060959865 @default.
• W2920854633 cites W2061142561 @default.
• W2920854633 cites W2062142305 @default.
• W2920854633 cites W2065278823 @default.
• W2920854633 cites W2068812356 @default.
• W2920854633 cites W2069438042 @default.
• W2920854633 cites W2072529314 @default.
• W2920854633 cites W2075667746 @default.
• W2920854633 cites W2080969849 @default.
• W2920854633 cites W2084606804 @default.
• W2920854633 cites W2085437800 @default.
• W2920854633 cites W2086663078 @default.
• W2920854633 cites W2089906199 @default.
• W2920854633 cites W2091650498 @default.
• W2920854633 cites W2099540110 @default.
• W2920854633 cites W2103624248 @default.
• W2920854633 cites W2105714029 @default.
• W2920854633 cites W2112590743 @default.
• W2920854633 cites W2127917887 @default.
• W2920854633 cites W2136647448 @default.
• W2920854633 cites W2149447750 @default.
• W2920854633 cites W2150197223 @default.
• W2920854633 cites W2156106096 @default.
• W2920854633 cites W2165535734 @default.
• W2920854633 cites W2167768320 @default.
• W2920854633 cites W2169949242 @default.
• W2920854633 cites W217559604 @default.
• W2920854633 cites W2243195272 @default.
• W2920854633 cites W2327099584 @default.
• W2920854633 cites W2466774112 @default.
• W2920854633 cites W2550356362 @default.
• W2920854633 cites W2556378489 @default.
• W2920854633 cites W2605370065 @default.
• W2920854633 cites W2606113495 @default.
• W2920854633 cites W2625968815 @default.
• W2920854633 cites W2789573965 @default.
• W2920854633 cites W2801397054 @default.
• W2920854633 cites W2809236918 @default.
• W2920854633 cites W2883891331 @default.
• W2920854633 cites W2888023784 @default.
• W2920854633 cites W2889842780 @default.
• W2920854633 cites W2904198162 @default.
• W2920854633 cites W2963242444 @default.
• W2920854633 cites W336760737 @default.
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• W2920854633 doi "https://doi.org/10.1085/jgp.201812301" @default.
• W2920854633 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6445577" @default.
• W2920854633 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30872560" @default.
• W2920854633 hasPublicationYear "2019" @default.
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