FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2920876248> ?p ?o ?g. }

• W2920876248 endingPage "808" @default.
• W2920876248 startingPage "800" @default.
• W2920876248 abstract "Objectives: To evaluate enhanced renal clearance over time in patients with aneurysmal subarachnoid hemorrhage or intracerebral hemorrhage via measured creatinine clearance and to compare measured creatinine clearance to creatinine clearance calculated by the Cockcroft-Gault equation and estimated glomerular filtration rate calculated by the Modification of Diet in Renal Diseases equation. Design: Prospective, observational study. Setting: Neurosciences ICU in a tertiary care academic medical center. Patients: Study participants had an admission diagnosis of aneurysmal subarachnoid hemorrhage or intracerebral hemorrhage, an expected neurosciences ICU length of stay greater than 48 hours, no evidence of renal dysfunction (admission serum creatinine < 1.5 mg/dL), and no history of chronic kidney disease. Interventions: Eight-hour urine collections to measure creatinine clearance were collected daily as the primary method of measuring renal function. Creatinine clearance was also calculated using the Cockcroft-Gault equation and estimated glomerular filtration rate was calculated using the Modification of Diet in Renal Disease equation. Enhanced renal clearance was defined as a measured creatinine clearance greater than the calculated creatinine clearance via Cockcroft-Gault and estimated glomerular filtration rate via Modification of Diet in Renal Disease. Augmented renal clearance was defined by a measured creatinine clearance greater than or equal to 130 mL/min/1.73 m 2 . Relevant demographic, clinical, and outcome data were recorded. Measurements and Main Results: Fifty aneurysmal subarachnoid hemorrhage patients and 30 intracerebral hemorrhage patients were enrolled, contributing 590 individual measurements. Patients with aneurysmal subarachnoid hemorrhage had a higher mean measured creatinine clearance compared with the mean calculated creatinine clearance based on the Cockcroft-Gault equation (147.9 ± 50.2 vs 109.1 ± 32.7 mL/min/1.73 m 2 ; p < 0.0001) and higher mean measured creatinine clearance compared with the mean calculated estimated glomerular filtration rate based on the Modification of Diet in Renal Disease equation (147.9 ± 50.2 vs 126.0 ± 41.9 mL/min/1.73 m 2 ; p = 0.04). Ninety-four percent of participants with aneurysmal subarachnoid hemorrhage experienced augmented renal clearance on at least 1 day. In patients with intracerebral hemorrhage, there was a higher mean measured creatinine clearance over the study period compared with the mean calculated creatinine clearance (119.5 ± 57.2 vs 77.8 ± 27.6 mL/min/1.73 m 2 ; p < 0.0001) and higher mean measured creatinine clearance compared with the mean calculated estimated glomerular filtration rate based on the Modification of Diet in Renal Disease equation (119.5 ± 57.2 vs 93.0.0 ± 32.8 mL/min/1.73 m 2 ; p = 0.02). Fifty percent of participants with intracerebral hemorrhage experienced augmented renal clearance on at least 1 day. Conclusions: A substantial group of patients with aneurysmal subarachnoid hemorrhage or intracerebral hemorrhage experienced enhanced renal clearance, which may be otherwise unknown to clinicians. Enhanced renal clearance may lead to increased renal solute elimination over what is expected, resulting in subtherapeutic renally eliminated drug concentrations. This may result in underexposure to critical medications, leading to treatment failure and other medical complications." @default.
• W2920876248 created "2019-03-22" @default.
• W2920876248 creator A5011757795 @default.
• W2920876248 creator A5020748269 @default.
• W2920876248 creator A5062162017 @default.
• W2920876248 creator A5067928315 @default.
• W2920876248 creator A5075190732 @default.
• W2920876248 creator A5081521738 @default.
• W2920876248 date "2019-06-01" @default.
• W2920876248 modified "2023-09-27" @default.
• W2920876248 title "Enhanced Renal Clearance in Patients With Hemorrhagic Stroke*" @default.
• W2920876248 cites W1934555000 @default.
• W2920876248 cites W1968671584 @default.
• W2920876248 cites W1969762322 @default.
• W2920876248 cites W1982034577 @default.
• W2920876248 cites W1990063730 @default.
• W2920876248 cites W2001055552 @default.
• W2920876248 cites W2006314650 @default.
• W2920876248 cites W2008071711 @default.
• W2920876248 cites W2015902971 @default.
• W2920876248 cites W2017797252 @default.
• W2920876248 cites W2018053572 @default.
• W2920876248 cites W2025227235 @default.
• W2920876248 cites W2026865446 @default.
• W2920876248 cites W2030491148 @default.
• W2920876248 cites W2037620834 @default.
• W2920876248 cites W2052024166 @default.
• W2920876248 cites W2053156248 @default.
• W2920876248 cites W2055774426 @default.
• W2920876248 cites W2055864845 @default.
• W2920876248 cites W2056607794 @default.
• W2920876248 cites W2056612376 @default.
• W2920876248 cites W2057226149 @default.
• W2920876248 cites W2059213454 @default.
• W2920876248 cites W2076122670 @default.
• W2920876248 cites W2078013380 @default.
• W2920876248 cites W2082780993 @default.
• W2920876248 cites W2089766560 @default.
• W2920876248 cites W2099953546 @default.
• W2920876248 cites W2100383570 @default.
• W2920876248 cites W2109804739 @default.
• W2920876248 cites W2127024827 @default.
• W2920876248 cites W2143069698 @default.
• W2920876248 cites W2149974939 @default.
• W2920876248 cites W2152901217 @default.
• W2920876248 cites W2157006832 @default.
• W2920876248 cites W2160467969 @default.
• W2920876248 cites W2160902978 @default.
• W2920876248 cites W2163232559 @default.
• W2920876248 cites W2165141447 @default.
• W2920876248 cites W2292369446 @default.
• W2920876248 cites W2509714450 @default.
• W2920876248 cites W2738371376 @default.
• W2920876248 cites W2786832455 @default.
• W2920876248 cites W2807738141 @default.
• W2920876248 cites W3171831654 @default.
• W2920876248 doi "https://doi.org/10.1097/ccm.0000000000003716" @default.
• W2920876248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30870191" @default.
• W2920876248 hasPublicationYear "2019" @default.
• W2920876248 type Work @default.
• W2920876248 sameAs 2920876248 @default.
• W2920876248 citedByCount "20" @default.
• W2920876248 countsByYear W29208762482019 @default.
• W2920876248 countsByYear W29208762482021 @default.
• W2920876248 countsByYear W29208762482022 @default.
• W2920876248 crossrefType "journal-article" @default.
• W2920876248 hasAuthorship W2920876248A5011757795 @default.
• W2920876248 hasAuthorship W2920876248A5020748269 @default.
• W2920876248 hasAuthorship W2920876248A5062162017 @default.
• W2920876248 hasAuthorship W2920876248A5067928315 @default.
• W2920876248 hasAuthorship W2920876248A5075190732 @default.
• W2920876248 hasAuthorship W2920876248A5081521738 @default.
• W2920876248 hasConcept C126322002 @default.
• W2920876248 hasConcept C126894567 @default.
• W2920876248 hasConcept C127413603 @default.
• W2920876248 hasConcept C159641895 @default.
• W2920876248 hasConcept C2777094939 @default.
• W2920876248 hasConcept C2777736543 @default.
• W2920876248 hasConcept C2778653478 @default.
• W2920876248 hasConcept C2780306776 @default.
• W2920876248 hasConcept C2780645631 @default.
• W2920876248 hasConcept C71924100 @default.
• W2920876248 hasConcept C78519656 @default.
• W2920876248 hasConceptScore W2920876248C126322002 @default.
• W2920876248 hasConceptScore W2920876248C126894567 @default.
• W2920876248 hasConceptScore W2920876248C127413603 @default.
• W2920876248 hasConceptScore W2920876248C159641895 @default.
• W2920876248 hasConceptScore W2920876248C2777094939 @default.
• W2920876248 hasConceptScore W2920876248C2777736543 @default.
• W2920876248 hasConceptScore W2920876248C2778653478 @default.
• W2920876248 hasConceptScore W2920876248C2780306776 @default.
• W2920876248 hasConceptScore W2920876248C2780645631 @default.
• W2920876248 hasConceptScore W2920876248C71924100 @default.
• W2920876248 hasConceptScore W2920876248C78519656 @default.
• W2920876248 hasIssue "6" @default.
• W2920876248 hasLocation W29208762481 @default.
• W2920876248 hasLocation W29208762482 @default.
• W2920876248 hasOpenAccess W2920876248 @default.

• next