FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2920952470> ?p ?o ?g. }

• W2920952470 endingPage "1591" @default.
• W2920952470 startingPage "1576" @default.
• W2920952470 abstract "Comparison of Mycobacterium tuberculosis with Escherichia coli reveals a reduction in the diversity of DNA-managing proteins, such as DNA topoisomerases, although genome sizes are similar for the two species. The same is true for nucleoid-associated proteins (NAPs), important factors in bacterial chromosome compaction, chromosome remodeling, and regulation of gene expression. In a search for still uncharacterized NAPs, we found that M. tuberculosis protein Rv0430 has NAP-like features: it binds to DNA in a length- and supercoil-dependent fashion, prefers A/T-rich DNA sequences, protects DNA from damaging agents, and modulates DNA supercoiling. At a ratio of 1 dimer/40 bps of DNA, Rv0430 bridges distant DNA segments; at 1 dimer/20 bps, it coats DNA, forming inflexible rods. Rv0430 also stimulates the DNA relaxation activity of topoisomerase I. Remarkably, Rv0430 stimulates its own promoter in a supercoil-dependent manner. It is the first gene of an operon harboring two regulators of M. tuberculosis virulence (virR and sodC), and controls the expression of these downstream virulence regulators and therefore itself is a virulence regulator. The sensitivity of rv0430 expression to supercoiling is consistent with supercoiling being important for infection by M. tuberculosis. Thus, Rv0430 is a novel NAP, doubling up as a topology modulator of M. tuberculosis." @default.
• W2920952470 created "2019-03-22" @default.
• W2920952470 creator A5006030743 @default.
• W2920952470 creator A5008285785 @default.
• W2920952470 creator A5064070525 @default.
• W2920952470 creator A5077668301 @default.
• W2920952470 date "2019-04-01" @default.
• W2920952470 modified "2023-10-07" @default.
• W2920952470 title "NapA (Rv0430), a Novel Nucleoid-Associated Protein that Regulates a Virulence Operon in Mycobacterium tuberculosis in a Supercoiling-Dependent Manner" @default.
• W2920952470 cites W1502474321 @default.
• W2920952470 cites W1578950175 @default.
• W2920952470 cites W1830481063 @default.
• W2920952470 cites W1938427307 @default.
• W2920952470 cites W1965218097 @default.
• W2920952470 cites W1966197698 @default.
• W2920952470 cites W1966913029 @default.
• W2920952470 cites W1972168116 @default.
• W2920952470 cites W1973517906 @default.
• W2920952470 cites W1974473584 @default.
• W2920952470 cites W1974819573 @default.
• W2920952470 cites W1977711073 @default.
• W2920952470 cites W1978527008 @default.
• W2920952470 cites W1979843975 @default.
• W2920952470 cites W1985345774 @default.
• W2920952470 cites W1985963323 @default.
• W2920952470 cites W1987925755 @default.
• W2920952470 cites W1989756617 @default.
• W2920952470 cites W1990445244 @default.
• W2920952470 cites W1990535832 @default.
• W2920952470 cites W1993675149 @default.
• W2920952470 cites W1995850701 @default.
• W2920952470 cites W1998203805 @default.
• W2920952470 cites W2003925078 @default.
• W2920952470 cites W2005318857 @default.
• W2920952470 cites W2007985102 @default.
• W2920952470 cites W2008015588 @default.
• W2920952470 cites W2008270769 @default.
• W2920952470 cites W2009653511 @default.
• W2920952470 cites W2013958276 @default.
• W2920952470 cites W2016160555 @default.
• W2920952470 cites W2016709199 @default.
• W2920952470 cites W2017516011 @default.
• W2920952470 cites W2022189854 @default.
• W2920952470 cites W2032113353 @default.
• W2920952470 cites W2032250800 @default.
• W2920952470 cites W2033560237 @default.
• W2920952470 cites W2044473542 @default.
• W2920952470 cites W2047671794 @default.
• W2920952470 cites W2052221476 @default.
• W2920952470 cites W2060468400 @default.
• W2920952470 cites W2064768985 @default.
• W2920952470 cites W2066080379 @default.
• W2920952470 cites W2067576392 @default.
• W2920952470 cites W2067600267 @default.
• W2920952470 cites W2072576748 @default.
• W2920952470 cites W2082927796 @default.
• W2920952470 cites W2090545518 @default.
• W2920952470 cites W2090558348 @default.
• W2920952470 cites W2090795034 @default.
• W2920952470 cites W2092419062 @default.
• W2920952470 cites W2096779123 @default.
• W2920952470 cites W2096781326 @default.
• W2920952470 cites W2096991651 @default.
• W2920952470 cites W2099577127 @default.
• W2920952470 cites W2107557066 @default.
• W2920952470 cites W2109771891 @default.
• W2920952470 cites W2109811392 @default.
• W2920952470 cites W2113717795 @default.
• W2920952470 cites W2116395964 @default.
• W2920952470 cites W2116576921 @default.
• W2920952470 cites W2119109353 @default.
• W2920952470 cites W2126156443 @default.
• W2920952470 cites W2127552033 @default.
• W2920952470 cites W2128482141 @default.
• W2920952470 cites W2128996981 @default.
• W2920952470 cites W2144300164 @default.
• W2920952470 cites W2145179825 @default.
• W2920952470 cites W2148295680 @default.
• W2920952470 cites W2148986226 @default.
• W2920952470 cites W2149840315 @default.
• W2920952470 cites W2154484815 @default.
• W2920952470 cites W2155347381 @default.
• W2920952470 cites W2160174395 @default.
• W2920952470 cites W2160256258 @default.
• W2920952470 cites W2162451787 @default.
• W2920952470 cites W2306419994 @default.
• W2920952470 cites W2308362620 @default.
• W2920952470 cites W2496885165 @default.
• W2920952470 cites W2766746896 @default.
• W2920952470 cites W2783742719 @default.
• W2920952470 doi "https://doi.org/10.1016/j.jmb.2019.02.029" @default.
• W2920952470 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30872139" @default.
• W2920952470 hasPublicationYear "2019" @default.
• W2920952470 type Work @default.
• W2920952470 sameAs 2920952470 @default.
• W2920952470 citedByCount "9" @default.
• W2920952470 countsByYear W29209524702019 @default.
• W2920952470 countsByYear W29209524702020 @default.

• next