Matches in SemOpenAlex for { <https://semopenalex.org/work/W2920955434> ?p ?o ?g. }
- W2920955434 endingPage "1107" @default.
- W2920955434 startingPage "1103" @default.
- W2920955434 abstract "Crystal structure of the KDEL receptor Eukaryotic cells concentrate chaperones in the lumen of the endoplasmic reticulum (ER). These chaperones can be swept along the secretory pathway to the Golgi apparatus, from where they must be returned. For 20 years, cell biologists have known the identity of the KDEL (Lys-Asp-Glu-Leu) receptor responsible for this process, but the molecular basis for its function has remained elusive. Now, Bräuer et al. present crystal structures of the KDEL receptor, in both the apo ER state and KDEL retrieval signal–bound Golgi state. Comparisons of these two states identify the conformational switch that exposes the ER retrieval motif. The authors recapitulated the binding and release cycle of the receptor using purified components, confirming that the receptor is the minimal component required to bind KDEL ligands in the Golgi. Science , this issue p. 1103" @default.
- W2920955434 created "2019-03-22" @default.
- W2920955434 creator A5017714497 @default.
- W2920955434 creator A5022968869 @default.
- W2920955434 creator A5033315873 @default.
- W2920955434 creator A5064649331 @default.
- W2920955434 creator A5065142739 @default.
- W2920955434 creator A5085801984 @default.
- W2920955434 creator A5086591800 @default.
- W2920955434 date "2019-03-08" @default.
- W2920955434 modified "2023-10-10" @default.
- W2920955434 title "Structural basis for pH-dependent retrieval of ER proteins from the Golgi by the KDEL receptor" @default.
- W2920955434 cites W1516276392 @default.
- W2920955434 cites W1536827165 @default.
- W2920955434 cites W1940906693 @default.
- W2920955434 cites W1983986068 @default.
- W2920955434 cites W2000504183 @default.
- W2920955434 cites W2006922696 @default.
- W2920955434 cites W2013083986 @default.
- W2920955434 cites W2023397454 @default.
- W2920955434 cites W2055286572 @default.
- W2920955434 cites W2058971645 @default.
- W2920955434 cites W2066015352 @default.
- W2920955434 cites W2080987586 @default.
- W2920955434 cites W2095429868 @default.
- W2920955434 cites W2102948276 @default.
- W2920955434 cites W2110808180 @default.
- W2920955434 cites W2115112794 @default.
- W2920955434 cites W2118964280 @default.
- W2920955434 cites W2124026197 @default.
- W2920955434 cites W2126953096 @default.
- W2920955434 cites W2145835877 @default.
- W2920955434 cites W2155682217 @default.
- W2920955434 cites W2157728632 @default.
- W2920955434 cites W2162613182 @default.
- W2920955434 cites W2163341755 @default.
- W2920955434 cites W2165161764 @default.
- W2920955434 cites W2167279371 @default.
- W2920955434 cites W2168987575 @default.
- W2920955434 cites W2171422037 @default.
- W2920955434 cites W2180229411 @default.
- W2920955434 cites W221247672 @default.
- W2920955434 cites W2218793017 @default.
- W2920955434 cites W2559655684 @default.
- W2920955434 cites W2737510383 @default.
- W2920955434 cites W2768448654 @default.
- W2920955434 cites W2793311671 @default.
- W2920955434 doi "https://doi.org/10.1126/science.aaw2859" @default.
- W2920955434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30846601" @default.
- W2920955434 hasPublicationYear "2019" @default.
- W2920955434 type Work @default.
- W2920955434 sameAs 2920955434 @default.
- W2920955434 citedByCount "95" @default.
- W2920955434 countsByYear W29209554342019 @default.
- W2920955434 countsByYear W29209554342020 @default.
- W2920955434 countsByYear W29209554342021 @default.
- W2920955434 countsByYear W29209554342022 @default.
- W2920955434 countsByYear W29209554342023 @default.
- W2920955434 crossrefType "journal-article" @default.
- W2920955434 hasAuthorship W2920955434A5017714497 @default.
- W2920955434 hasAuthorship W2920955434A5022968869 @default.
- W2920955434 hasAuthorship W2920955434A5033315873 @default.
- W2920955434 hasAuthorship W2920955434A5064649331 @default.
- W2920955434 hasAuthorship W2920955434A5065142739 @default.
- W2920955434 hasAuthorship W2920955434A5085801984 @default.
- W2920955434 hasAuthorship W2920955434A5086591800 @default.
- W2920955434 hasBestOaLocation W29209554341 @default.
- W2920955434 hasConcept C104317684 @default.
- W2920955434 hasConcept C119062480 @default.
- W2920955434 hasConcept C143065580 @default.
- W2920955434 hasConcept C158617107 @default.
- W2920955434 hasConcept C170493617 @default.
- W2920955434 hasConcept C185592680 @default.
- W2920955434 hasConcept C2778043179 @default.
- W2920955434 hasConcept C2779377555 @default.
- W2920955434 hasConcept C55493867 @default.
- W2920955434 hasConcept C6492254 @default.
- W2920955434 hasConcept C86803240 @default.
- W2920955434 hasConcept C95444343 @default.
- W2920955434 hasConceptScore W2920955434C104317684 @default.
- W2920955434 hasConceptScore W2920955434C119062480 @default.
- W2920955434 hasConceptScore W2920955434C143065580 @default.
- W2920955434 hasConceptScore W2920955434C158617107 @default.
- W2920955434 hasConceptScore W2920955434C170493617 @default.
- W2920955434 hasConceptScore W2920955434C185592680 @default.
- W2920955434 hasConceptScore W2920955434C2778043179 @default.
- W2920955434 hasConceptScore W2920955434C2779377555 @default.
- W2920955434 hasConceptScore W2920955434C55493867 @default.
- W2920955434 hasConceptScore W2920955434C6492254 @default.
- W2920955434 hasConceptScore W2920955434C86803240 @default.
- W2920955434 hasConceptScore W2920955434C95444343 @default.
- W2920955434 hasFunder F4320307874 @default.
- W2920955434 hasFunder F4320320924 @default.
- W2920955434 hasFunder F4320320998 @default.
- W2920955434 hasFunder F4320323874 @default.
- W2920955434 hasIssue "6431" @default.
- W2920955434 hasLocation W29209554341 @default.
- W2920955434 hasLocation W29209554342 @default.