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- W2920970656 endingPage "101787" @default.
- W2920970656 startingPage "101787" @default.
- W2920970656 abstract "Preterm infants are at high risk for brain injury during the perinatal period. Intraventricular hemorrhage and periventricular leukomalacia, the two most common patterns of brain injury in prematurely-born children, are associated with poor neurodevelopmental outcomes. The hippocampus is known to be critical for learning and memory; however, it remains unknown how these forms of brain injury affect hippocampal growth and how the resulting alterations in hippocampal development relate to childhood outcomes. To investigate these relationships, hippocampal segmentations were performed on term equivalent MRI scans from 55 full-term infants, 85 very preterm infants (born ≤32 weeks gestation) with no to mild brain injury and 73 very preterm infants with brain injury (e.g., grade III/IV intraventricular hemorrhage, post-hemorrhagic hydrocephalus, cystic periventricular leukomalacia). Infants then underwent standardized neurodevelopmental testing using the Bayley Scales of Infant and Toddler Development, 3rd edition at age 2 years, corrected for prematurity. To delineate the effects of brain injury on early hippocampal development, hippocampal volumes were compared across groups and associations between neonatal volumes and neurodevelopmental outcomes at age 2 years were explored. Very preterm infants with brain injury had smaller hippocampal volumes at term equivalent age compared to term and very preterm infants with no to mild injury, with the smallest hippocampi among those with grade III/IV intraventricular hemorrhage and post-hemorrhagic hydrocephalus. Further, larger ventricle size was associated with smaller hippocampal size. Smaller hippocampal volumes were related to worse motor performance at age 2 years across all groups. In addition, smaller hippocampal volumes in infants with brain injury were correlated with impaired cognitive scores at age 2 years, a relationship specific to this group. Consistent with our preclinical findings, these findings demonstrate that perinatal brain injury is associated with hippocampal size in preterm infants, with smaller volumes related to domain-specific neurodevelopmental impairments in this high-risk clinical population." @default.
- W2920970656 created "2019-03-22" @default.
- W2920970656 creator A5010634604 @default.
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- W2920970656 creator A5057295149 @default.
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- W2920970656 date "2019-01-01" @default.
- W2920970656 modified "2023-10-17" @default.
- W2920970656 title "Impaired hippocampal development and outcomes in very preterm infants with perinatal brain injury" @default.
- W2920970656 cites W1510435719 @default.
- W2920970656 cites W1575596763 @default.
- W2920970656 cites W1579185664 @default.
- W2920970656 cites W169256928 @default.
- W2920970656 cites W1857797615 @default.
- W2920970656 cites W1914981007 @default.
- W2920970656 cites W1965021131 @default.
- W2920970656 cites W1965245442 @default.
- W2920970656 cites W1970874907 @default.
- W2920970656 cites W1972149259 @default.
- W2920970656 cites W1972586613 @default.
- W2920970656 cites W1973882764 @default.
- W2920970656 cites W1975284164 @default.
- W2920970656 cites W1976341012 @default.
- W2920970656 cites W1976645944 @default.
- W2920970656 cites W1979804471 @default.
- W2920970656 cites W1981252180 @default.
- W2920970656 cites W1981713450 @default.
- W2920970656 cites W1983553991 @default.
- W2920970656 cites W1983706099 @default.
- W2920970656 cites W1985787128 @default.
- W2920970656 cites W1987267692 @default.
- W2920970656 cites W1987409034 @default.
- W2920970656 cites W1989571226 @default.
- W2920970656 cites W1989635542 @default.
- W2920970656 cites W1994779687 @default.
- W2920970656 cites W1997551248 @default.
- W2920970656 cites W2000361391 @default.
- W2920970656 cites W2001192596 @default.
- W2920970656 cites W2002732753 @default.
- W2920970656 cites W2004372993 @default.
- W2920970656 cites W2004430462 @default.
- W2920970656 cites W2007550342 @default.
- W2920970656 cites W2007644749 @default.
- W2920970656 cites W2011068734 @default.
- W2920970656 cites W2013522247 @default.
- W2920970656 cites W2017311476 @default.
- W2920970656 cites W2019167416 @default.
- W2920970656 cites W2025373266 @default.
- W2920970656 cites W2026023486 @default.
- W2920970656 cites W2031420920 @default.
- W2920970656 cites W2031531158 @default.
- W2920970656 cites W2040390347 @default.
- W2920970656 cites W2046094677 @default.
- W2920970656 cites W2046189979 @default.
- W2920970656 cites W2046224781 @default.
- W2920970656 cites W2048605353 @default.
- W2920970656 cites W2052672935 @default.
- W2920970656 cites W2057339629 @default.
- W2920970656 cites W2059546081 @default.
- W2920970656 cites W2065461184 @default.
- W2920970656 cites W2069976445 @default.
- W2920970656 cites W2071471912 @default.
- W2920970656 cites W2077001286 @default.
- W2920970656 cites W2079949956 @default.
- W2920970656 cites W2084669703 @default.
- W2920970656 cites W2090859832 @default.
- W2920970656 cites W2095358141 @default.
- W2920970656 cites W2095752503 @default.
- W2920970656 cites W2095988793 @default.
- W2920970656 cites W2100554620 @default.
- W2920970656 cites W2100934711 @default.
- W2920970656 cites W2102806222 @default.
- W2920970656 cites W2106169429 @default.
- W2920970656 cites W2106681349 @default.
- W2920970656 cites W2109104538 @default.
- W2920970656 cites W2112836819 @default.
- W2920970656 cites W2120470271 @default.
- W2920970656 cites W2123293994 @default.
- W2920970656 cites W2125131245 @default.
- W2920970656 cites W2130854112 @default.
- W2920970656 cites W2131014005 @default.
- W2920970656 cites W2140984125 @default.
- W2920970656 cites W2141908730 @default.
- W2920970656 cites W2144966005 @default.
- W2920970656 cites W2153732322 @default.
- W2920970656 cites W2158698668 @default.
- W2920970656 cites W2160895091 @default.
- W2920970656 cites W2161144725 @default.
- W2920970656 cites W2168619128 @default.
- W2920970656 cites W2169101968 @default.
- W2920970656 cites W2228866506 @default.
- W2920970656 cites W2312828294 @default.
- W2920970656 cites W2313210773 @default.
- W2920970656 cites W2319815943 @default.
- W2920970656 cites W2334257287 @default.