FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2920973954> ?p ?o ?g. }

• W2920973954 endingPage "1776" @default.
• W2920973954 startingPage "1766" @default.
• W2920973954 abstract "Abstract Background Hyaluronidases (HAases), enzymes that degrade hyaluronan, have been widely investigated in cancer biology. However, whether HAases serve as tumor promoters or suppressors has been controversial in different cancers, and the exact role of HAases in colorectal cancer (CRC) has not been elucidated. Methods The expression levels of HYAL1, HYAL2, and HYAL3 in cancer and corresponding normal tissues from CRC patients were examined via immunohistochemistry. Then the correlation between HAases levels and pathological characteristics of CRC patients was analyzed. To verify the clinical data, HYAL1 and HYAL2 were downregulated or overexpressed in colon cancer cells LOVO and HCT116 to observe their influences on cell invasion and migration. For the mechanism study, we investigated the effects of HYAL1 and HYAL2 on the expression of matrix metalloproteases (MMPs)/tissue inhibitor of metalloproteases (TIMPs) and distribution of F‐actin. Results All the three HAases were abnormally elevated in cancer tissues. Interestingly, HYAL1 and HYAL2, but not HYAL3, were negatively correlated with lymphatic metastasis and TNM stage. When HYAL1 and HYAL2 were knocked down, the invasion and migration abilities of colon cancer cells were accelerated, whereas overexpression of HYAL1 and HYAL2 had the opposite effects. In addition, colon cancer cells with HYAL1 and HYAL2 downregulation showed increased levels of MMP2 and MMP9, decreased levels of TIMP1 and TIMP2, and more intense F‐actin stress fibers. Conclusions Our study suggests that HYAL1 and HYAL2 suppress CRC metastasis through regulating MMPs/TIMPs balance and rearranging F‐actin distribution, further inhibiting invasion and migration of cancer cells." @default.
• W2920973954 created "2019-03-22" @default.
• W2920973954 creator A5003852242 @default.
• W2920973954 creator A5028948838 @default.
• W2920973954 creator A5030419296 @default.
• W2920973954 creator A5036189659 @default.
• W2920973954 creator A5049924184 @default.
• W2920973954 creator A5053528169 @default.
• W2920973954 creator A5084266744 @default.
• W2920973954 date "2019-04-10" @default.
• W2920973954 modified "2023-10-15" @default.
• W2920973954 title "The suppressive role of HYAL1 and HYAL2 in the metastasis of colorectal cancer" @default.
• W2920973954 cites W1511612393 @default.
• W2920973954 cites W1782904287 @default.
• W2920973954 cites W1864824629 @default.
• W2920973954 cites W1967834755 @default.
• W2920973954 cites W1973332589 @default.
• W2920973954 cites W1977690808 @default.
• W2920973954 cites W1985044730 @default.
• W2920973954 cites W1999087336 @default.
• W2920973954 cites W2000688089 @default.
• W2920973954 cites W2005318950 @default.
• W2920973954 cites W2022295066 @default.
• W2920973954 cites W2030533818 @default.
• W2920973954 cites W2039593341 @default.
• W2920973954 cites W2051728526 @default.
• W2920973954 cites W2065895195 @default.
• W2920973954 cites W2067014191 @default.
• W2920973954 cites W2077810031 @default.
• W2920973954 cites W2081057626 @default.
• W2920973954 cites W2092100136 @default.
• W2920973954 cites W2093105418 @default.
• W2920973954 cites W2105173347 @default.
• W2920973954 cites W2107214690 @default.
• W2920973954 cites W2113431340 @default.
• W2920973954 cites W2113745903 @default.
• W2920973954 cites W2127466034 @default.
• W2920973954 cites W2131554707 @default.
• W2920973954 cites W2165948908 @default.
• W2920973954 cites W2592565933 @default.
• W2920973954 cites W2770885214 @default.
• W2920973954 doi "https://doi.org/10.1111/jgh.14660" @default.
• W2920973954 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30972813" @default.
• W2920973954 hasPublicationYear "2019" @default.
• W2920973954 type Work @default.
• W2920973954 sameAs 2920973954 @default.
• W2920973954 citedByCount "14" @default.
• W2920973954 countsByYear W29209739542020 @default.
• W2920973954 countsByYear W29209739542021 @default.
• W2920973954 countsByYear W29209739542022 @default.
• W2920973954 countsByYear W29209739542023 @default.
• W2920973954 crossrefType "journal-article" @default.
• W2920973954 hasAuthorship W2920973954A5003852242 @default.
• W2920973954 hasAuthorship W2920973954A5028948838 @default.
• W2920973954 hasAuthorship W2920973954A5030419296 @default.
• W2920973954 hasAuthorship W2920973954A5036189659 @default.
• W2920973954 hasAuthorship W2920973954A5049924184 @default.
• W2920973954 hasAuthorship W2920973954A5053528169 @default.
• W2920973954 hasAuthorship W2920973954A5084266744 @default.
• W2920973954 hasConcept C104317684 @default.
• W2920973954 hasConcept C109523444 @default.
• W2920973954 hasConcept C121608353 @default.
• W2920973954 hasConcept C126322002 @default.
• W2920973954 hasConcept C127561419 @default.
• W2920973954 hasConcept C146357865 @default.
• W2920973954 hasConcept C150194340 @default.
• W2920973954 hasConcept C151730666 @default.
• W2920973954 hasConcept C2775997469 @default.
• W2920973954 hasConcept C2779013556 @default.
• W2920973954 hasConcept C2780692422 @default.
• W2920973954 hasConcept C2780699576 @default.
• W2920973954 hasConcept C502942594 @default.
• W2920973954 hasConcept C526805850 @default.
• W2920973954 hasConcept C55493867 @default.
• W2920973954 hasConcept C71924100 @default.
• W2920973954 hasConcept C86803240 @default.
• W2920973954 hasConceptScore W2920973954C104317684 @default.
• W2920973954 hasConceptScore W2920973954C109523444 @default.
• W2920973954 hasConceptScore W2920973954C121608353 @default.
• W2920973954 hasConceptScore W2920973954C126322002 @default.
• W2920973954 hasConceptScore W2920973954C127561419 @default.
• W2920973954 hasConceptScore W2920973954C146357865 @default.
• W2920973954 hasConceptScore W2920973954C150194340 @default.
• W2920973954 hasConceptScore W2920973954C151730666 @default.
• W2920973954 hasConceptScore W2920973954C2775997469 @default.
• W2920973954 hasConceptScore W2920973954C2779013556 @default.
• W2920973954 hasConceptScore W2920973954C2780692422 @default.
• W2920973954 hasConceptScore W2920973954C2780699576 @default.
• W2920973954 hasConceptScore W2920973954C502942594 @default.
• W2920973954 hasConceptScore W2920973954C526805850 @default.
• W2920973954 hasConceptScore W2920973954C55493867 @default.
• W2920973954 hasConceptScore W2920973954C71924100 @default.
• W2920973954 hasConceptScore W2920973954C86803240 @default.
• W2920973954 hasFunder F4320321001 @default.
• W2920973954 hasIssue "10" @default.
• W2920973954 hasLocation W29209739541 @default.
• W2920973954 hasLocation W29209739542 @default.
• W2920973954 hasOpenAccess W2920973954 @default.

• next