FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2920981918> ?p ?o ?g. }

• W2920981918 abstract "Overexpression of the murine double minute 2 (MDM2) has been explored in many tumors with high proliferation and anti-apoptosis ability. However, the role of MDM2 and its functional single nucleotide polymorphism (SNP) rs2279744 (also known as SNP309) in esophageal squamous cell carcinoma (ESCC) remains unclear.We performed a genotype study of blood samples in 360 ESCC patients and 360 healthy control individuals to determine the risk of various rs2279744 in ESCC. To further evaluate the role of rs2279744 in regulating MDM2 expression, we performed an allele-specific reporter assay and investigated whether the SNP-containing sequences functioned as an active enhancer. To examine the functional role of MDM2 on esophageal cancer cell lines, we carried out an MTS assay and flow cytometry analysis.From the genotyping study, we found that GG genotype of SNP309 significantly increased the risk of ESCC in an additive model [odds ratio (OR) = 2.55, 95% confidence interval (CI) = 1.66-3.89, p = 1.50 × 10-5 ) and in a recessive model (OR = 2.44, 95% CI = 1.69-3.51, p = 1.60 × 10-8 ). Furthermore, the G allele was significantly associated with a higher risk of ESCC (OR = 1.56, 95% CI = 1.26-1.92, p = 2.81 × 10-5 ). In multivariate logistic regression analysis, the GG genotype had increased the occurrence of ESCC by 2.39-fold (95% CI = 1.48-3.8). Compared to the T allele, the variant G allele had significantly higher luciferase activity on the promoter of MDM2 in both cell lines. By transfecting the gene to ESCC lines, we showed that overexpression of MDM2 significantly promote cell proliferation and anti-apoptosis.The MDM2 promoter SNP309 is a risk factor for esophageal cancer. MDM2 promotes the proliferation and anti-apoptosis of ESCC." @default.
• W2920981918 created "2019-03-22" @default.
• W2920981918 creator A5021392958 @default.
• W2920981918 creator A5021701516 @default.
• W2920981918 creator A5070144271 @default.
• W2920981918 creator A5084195289 @default.
• W2920981918 creator A5091486977 @default.
• W2920981918 date "2019-04-08" @default.
• W2920981918 modified "2023-10-16" @default.
• W2920981918 title "<i>MDM2</i> and its functional polymorphism SNP309 contribute to the development of esophageal carcinoma" @default.
• W2920981918 cites W1545000863 @default.
• W2920981918 cites W1976261939 @default.
• W2920981918 cites W1982545718 @default.
• W2920981918 cites W1984235851 @default.
• W2920981918 cites W1985273972 @default.
• W2920981918 cites W1999416824 @default.
• W2920981918 cites W2015237564 @default.
• W2920981918 cites W2021581476 @default.
• W2920981918 cites W2050963387 @default.
• W2920981918 cites W2083974327 @default.
• W2920981918 cites W2086943685 @default.
• W2920981918 cites W2090450640 @default.
• W2920981918 cites W2091151265 @default.
• W2920981918 cites W2094042239 @default.
• W2920981918 cites W2103026005 @default.
• W2920981918 cites W2113236360 @default.
• W2920981918 cites W2134612158 @default.
• W2920981918 cites W2152587975 @default.
• W2920981918 cites W2157004084 @default.
• W2920981918 cites W2166503791 @default.
• W2920981918 cites W2219655163 @default.
• W2920981918 cites W2484420184 @default.
• W2920981918 cites W2515452405 @default.
• W2920981918 cites W2566076681 @default.
• W2920981918 cites W2588865557 @default.
• W2920981918 cites W2801232817 @default.
• W2920981918 doi "https://doi.org/10.1002/jgm.3086" @default.
• W2920981918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30861607" @default.
• W2920981918 hasPublicationYear "2019" @default.
• W2920981918 type Work @default.
• W2920981918 sameAs 2920981918 @default.
• W2920981918 citedByCount "3" @default.
• W2920981918 countsByYear W29209819182019 @default.
• W2920981918 countsByYear W29209819182020 @default.
• W2920981918 countsByYear W29209819182023 @default.
• W2920981918 crossrefType "journal-article" @default.
• W2920981918 hasAuthorship W2920981918A5021392958 @default.
• W2920981918 hasAuthorship W2920981918A5021701516 @default.
• W2920981918 hasAuthorship W2920981918A5070144271 @default.
• W2920981918 hasAuthorship W2920981918A5084195289 @default.
• W2920981918 hasAuthorship W2920981918A5091486977 @default.
• W2920981918 hasConcept C104317684 @default.
• W2920981918 hasConcept C126322002 @default.
• W2920981918 hasConcept C135763542 @default.
• W2920981918 hasConcept C139275648 @default.
• W2920981918 hasConcept C143998085 @default.
• W2920981918 hasConcept C153209595 @default.
• W2920981918 hasConcept C153911025 @default.
• W2920981918 hasConcept C156957248 @default.
• W2920981918 hasConcept C180754005 @default.
• W2920981918 hasConcept C190283241 @default.
• W2920981918 hasConcept C2776192174 @default.
• W2920981918 hasConcept C31467283 @default.
• W2920981918 hasConcept C44249647 @default.
• W2920981918 hasConcept C502942594 @default.
• W2920981918 hasConcept C54355233 @default.
• W2920981918 hasConcept C71924100 @default.
• W2920981918 hasConcept C86803240 @default.
• W2920981918 hasConceptScore W2920981918C104317684 @default.
• W2920981918 hasConceptScore W2920981918C126322002 @default.
• W2920981918 hasConceptScore W2920981918C135763542 @default.
• W2920981918 hasConceptScore W2920981918C139275648 @default.
• W2920981918 hasConceptScore W2920981918C143998085 @default.
• W2920981918 hasConceptScore W2920981918C153209595 @default.
• W2920981918 hasConceptScore W2920981918C153911025 @default.
• W2920981918 hasConceptScore W2920981918C156957248 @default.
• W2920981918 hasConceptScore W2920981918C180754005 @default.
• W2920981918 hasConceptScore W2920981918C190283241 @default.
• W2920981918 hasConceptScore W2920981918C2776192174 @default.
• W2920981918 hasConceptScore W2920981918C31467283 @default.
• W2920981918 hasConceptScore W2920981918C44249647 @default.
• W2920981918 hasConceptScore W2920981918C502942594 @default.
• W2920981918 hasConceptScore W2920981918C54355233 @default.
• W2920981918 hasConceptScore W2920981918C71924100 @default.
• W2920981918 hasConceptScore W2920981918C86803240 @default.
• W2920981918 hasIssue "5" @default.
• W2920981918 hasLocation W29209819181 @default.
• W2920981918 hasLocation W29209819182 @default.
• W2920981918 hasOpenAccess W2920981918 @default.
• W2920981918 hasPrimaryLocation W29209819181 @default.
• W2920981918 hasRelatedWork W121700474 @default.
• W2920981918 hasRelatedWork W1504890006 @default.
• W2920981918 hasRelatedWork W1508523048 @default.
• W2920981918 hasRelatedWork W2056355462 @default.
• W2920981918 hasRelatedWork W2057739827 @default.
• W2920981918 hasRelatedWork W2090450640 @default.
• W2920981918 hasRelatedWork W2164332050 @default.
• W2920981918 hasRelatedWork W2184363627 @default.
• W2920981918 hasRelatedWork W2329658823 @default.
• W2920981918 hasRelatedWork W4246971673 @default.

• next