FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2920989072> ?p ?o ?g. }

• W2920989072 endingPage "134" @default.
• W2920989072 startingPage "124" @default.
• W2920989072 abstract "Bisphenol A (BPA), a synthetic monomer commonly included in the daily products, has a structure similar to the estrogen receptor agonist. Therefore BPA has been anticipated to interfere with the hormone metabolisms and cause diverse pathological conditions. But the effects of BPA on the genetic landscapes of liver or hepatic cells have not been fully established. Gene expressional changes induced by low- or high-dose of BPA were evaluated in 3D cultured human hepatoma cells (HepG2 spheroids) in vitro at 0, 0.5, 5 and 200 μM and liver of rats exposed to BPA at 0, 0.5 and 250 mg/kg for 90 days in vivo. Functional enrichment analysis, pathway activity measurement and network analysis were performed using BPA-responsive genes. Treatment with BPA changed a lot of gene expressions in both HepG2 spheroids and rat livers depending on doses of BPA. Functional enrichment and pathway analysis show that lipid or steroid metabolism-related functions were altered by BPA in both HepG2 spheroids and livers of rats. Lipid metabolism-related functions altered by BPA formed a large cluster encompassing lipid biosynthesis, steroid metabolic process and cholesterol regulation process. It was also observed that distribution of pathway activities was correlated between HepG2 spheroids and rat livers at low-dose of BPA. Distance distribution in protein-protein interaction network also evidenced the closeness of BPA-responsive genes to metabolism pathways which include lipid metabolism. Collectively, we demonstrated that BPA greatly influenced overall gene expression and biological functions in both human hepatoma spheroids and rat liver, in which lipid- or steroid metabolism-associated genes were significantly altered by the exposure to BPA." @default.
• W2920989072 created "2019-03-22" @default.
• W2920989072 creator A5007611070 @default.
• W2920989072 creator A5020439765 @default.
• W2920989072 creator A5027214907 @default.
• W2920989072 creator A5044597411 @default.
• W2920989072 creator A5056582718 @default.
• W2920989072 creator A5061215639 @default.
• W2920989072 creator A5067207199 @default.
• W2920989072 creator A5075106657 @default.
• W2920989072 creator A5087783301 @default.
• W2920989072 date "2019-06-01" @default.
• W2920989072 modified "2023-10-15" @default.
• W2920989072 title "Comprehensive analysis of transcriptomic changes induced by low and high doses of bisphenol A in HepG2 spheroids in vitro and rat liver in vivo" @default.
• W2920989072 cites W1546043964 @default.
• W2920989072 cites W1967211742 @default.
• W2920989072 cites W1969191244 @default.
• W2920989072 cites W1989523709 @default.
• W2920989072 cites W2038472343 @default.
• W2920989072 cites W2041693476 @default.
• W2920989072 cites W2048197369 @default.
• W2920989072 cites W2053570362 @default.
• W2920989072 cites W2054033346 @default.
• W2920989072 cites W2067753015 @default.
• W2920989072 cites W2076995497 @default.
• W2920989072 cites W2108900261 @default.
• W2920989072 cites W2109780493 @default.
• W2920989072 cites W2110905563 @default.
• W2920989072 cites W2119034410 @default.
• W2920989072 cites W2120865735 @default.
• W2920989072 cites W2122683221 @default.
• W2920989072 cites W2145415601 @default.
• W2920989072 cites W2167098478 @default.
• W2920989072 cites W2169589032 @default.
• W2920989072 cites W2504592607 @default.
• W2920989072 cites W2584013461 @default.
• W2920989072 cites W2611441981 @default.
• W2920989072 cites W2612467560 @default.
• W2920989072 cites W2619143987 @default.
• W2920989072 cites W2740529462 @default.
• W2920989072 cites W2750119263 @default.
• W2920989072 cites W2753856900 @default.
• W2920989072 cites W2767152490 @default.
• W2920989072 cites W2767941096 @default.
• W2920989072 cites W2775631926 @default.
• W2920989072 cites W2796512387 @default.
• W2920989072 cites W2884517527 @default.
• W2920989072 cites W2889107532 @default.
• W2920989072 cites W4294107304 @default.
• W2920989072 doi "https://doi.org/10.1016/j.envres.2019.03.035" @default.
• W2920989072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30903817" @default.
• W2920989072 hasPublicationYear "2019" @default.
• W2920989072 type Work @default.
• W2920989072 sameAs 2920989072 @default.
• W2920989072 citedByCount "8" @default.
• W2920989072 countsByYear W29209890722020 @default.
• W2920989072 countsByYear W29209890722022 @default.
• W2920989072 countsByYear W29209890722023 @default.
• W2920989072 crossrefType "journal-article" @default.
• W2920989072 hasAuthorship W2920989072A5007611070 @default.
• W2920989072 hasAuthorship W2920989072A5020439765 @default.
• W2920989072 hasAuthorship W2920989072A5027214907 @default.
• W2920989072 hasAuthorship W2920989072A5044597411 @default.
• W2920989072 hasAuthorship W2920989072A5056582718 @default.
• W2920989072 hasAuthorship W2920989072A5061215639 @default.
• W2920989072 hasAuthorship W2920989072A5067207199 @default.
• W2920989072 hasAuthorship W2920989072A5075106657 @default.
• W2920989072 hasAuthorship W2920989072A5087783301 @default.
• W2920989072 hasConcept C104317684 @default.
• W2920989072 hasConcept C121608353 @default.
• W2920989072 hasConcept C126322002 @default.
• W2920989072 hasConcept C134018914 @default.
• W2920989072 hasConcept C150194340 @default.
• W2920989072 hasConcept C150903083 @default.
• W2920989072 hasConcept C162317418 @default.
• W2920989072 hasConcept C166595027 @default.
• W2920989072 hasConcept C175369904 @default.
• W2920989072 hasConcept C178790620 @default.
• W2920989072 hasConcept C185592680 @default.
• W2920989072 hasConcept C202751555 @default.
• W2920989072 hasConcept C207001950 @default.
• W2920989072 hasConcept C2776175330 @default.
• W2920989072 hasConcept C2779684741 @default.
• W2920989072 hasConcept C4733338 @default.
• W2920989072 hasConcept C530470458 @default.
• W2920989072 hasConcept C54355233 @default.
• W2920989072 hasConcept C55493867 @default.
• W2920989072 hasConcept C62231903 @default.
• W2920989072 hasConcept C71924100 @default.
• W2920989072 hasConcept C84606932 @default.
• W2920989072 hasConcept C86803240 @default.
• W2920989072 hasConcept C9927688 @default.
• W2920989072 hasConceptScore W2920989072C104317684 @default.
• W2920989072 hasConceptScore W2920989072C121608353 @default.
• W2920989072 hasConceptScore W2920989072C126322002 @default.
• W2920989072 hasConceptScore W2920989072C134018914 @default.
• W2920989072 hasConceptScore W2920989072C150194340 @default.
• W2920989072 hasConceptScore W2920989072C150903083 @default.

• next