FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2921032705> ?p ?o ?g. }

• W2921032705 endingPage "43" @default.
• W2921032705 startingPage "36" @default.
• W2921032705 abstract "Snake venoms as well as their components have been tested worldwide to find new molecules for prophylaxis and treatment of several pathologies or even for diagnostic purposes. It is widely known that snake venoms contain enzymes and non-enzymatic proteins that interfere with hemostasis leading to hemorrhage or even thrombosis. The treatment of snake envenoming and the development of new drugs. The thrombin generation test (TGT) is a highly sensitive tool for investigation of hemostatic changes, overlapping with existing coagulometric techniques. The aim of this study was to use TGT to evaluate in vitro hemostatic changes caused by venom of Brazilian snakes B. jararacussu, B. alternatus, B. moojeni and C. durissus terrificus in a normal pool of platelet-poor plasma, comparing results to those obtained by the classical coagulation assays, at the same concentrations of venom. B. moojeni venom showed to be more hypercoagulable, with a greater ability to activate coagulation, evidenced by increased values of Endogenous Thrombin Potential (ETP), even in the reactions in which the triggering reagent (tissue factor) was not added. On the other hand, the lowest ETP values were observed in plasma incubated with C. durissus terrificus venom. As a new finding of great importance, all venoms at the same concentrations assessed by TGT did not promote changes in a pool of platelet-poor plasma by classic coagulometric assays, such as prothrombin time (PT) and activated partial thromboplastin time (aPTT), whose results were within the reference range. Thus, TGT showed to be more sensitive than the coagulometric assays to evaluate the hemostatic effect of venom components in vitro. Our preliminary results indicate a potential role for TGT in improving the laboratory investigation of hemostatic changes due to snakebite. In addition, elucidation of hemostatic changes induced by different Brazilian snake venoms related to hypocoagulability or hypercoagulability represents an important approach to improving the treatment of snake envenoming and the development of new drugs." @default.
• W2921032705 created "2019-03-22" @default.
• W2921032705 creator A5019047278 @default.
• W2921032705 creator A5025811358 @default.
• W2921032705 creator A5050211466 @default.
• W2921032705 creator A5069218271 @default.
• W2921032705 creator A5072617485 @default.
• W2921032705 creator A5089828291 @default.
• W2921032705 date "2019-05-01" @default.
• W2921032705 modified "2023-10-17" @default.
• W2921032705 title "Thrombin generation test for evaluating hemostatic effects of Brazilian snake venoms" @default.
• W2921032705 cites W1964529378 @default.
• W2921032705 cites W1972970439 @default.
• W2921032705 cites W2027259074 @default.
• W2921032705 cites W2029124049 @default.
• W2921032705 cites W2040036901 @default.
• W2921032705 cites W2042957352 @default.
• W2921032705 cites W2048013243 @default.
• W2921032705 cites W2058775318 @default.
• W2921032705 cites W2065142535 @default.
• W2921032705 cites W2095982855 @default.
• W2921032705 cites W2119768870 @default.
• W2921032705 cites W2123050335 @default.
• W2921032705 cites W2527520038 @default.
• W2921032705 cites W2741798088 @default.
• W2921032705 cites W2750293594 @default.
• W2921032705 cites W2792475511 @default.
• W2921032705 cites W2800248379 @default.
• W2921032705 cites W2897273029 @default.
• W2921032705 cites W620150056 @default.
• W2921032705 doi "https://doi.org/10.1016/j.toxicon.2019.03.012" @default.
• W2921032705 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30880188" @default.
• W2921032705 hasPublicationYear "2019" @default.
• W2921032705 type Work @default.
• W2921032705 sameAs 2921032705 @default.
• W2921032705 citedByCount "13" @default.
• W2921032705 countsByYear W29210327052019 @default.
• W2921032705 countsByYear W29210327052020 @default.
• W2921032705 countsByYear W29210327052021 @default.
• W2921032705 countsByYear W29210327052022 @default.
• W2921032705 countsByYear W29210327052023 @default.
• W2921032705 crossrefType "journal-article" @default.
• W2921032705 hasAuthorship W2921032705A5019047278 @default.
• W2921032705 hasAuthorship W2921032705A5025811358 @default.
• W2921032705 hasAuthorship W2921032705A5050211466 @default.
• W2921032705 hasAuthorship W2921032705A5069218271 @default.
• W2921032705 hasAuthorship W2921032705A5072617485 @default.
• W2921032705 hasAuthorship W2921032705A5089828291 @default.
• W2921032705 hasConcept C126322002 @default.
• W2921032705 hasConcept C144594695 @default.
• W2921032705 hasConcept C185592680 @default.
• W2921032705 hasConcept C186738567 @default.
• W2921032705 hasConcept C203014093 @default.
• W2921032705 hasConcept C2776725428 @default.
• W2921032705 hasConcept C2777292125 @default.
• W2921032705 hasConcept C2778261982 @default.
• W2921032705 hasConcept C2778382381 @default.
• W2921032705 hasConcept C2778589496 @default.
• W2921032705 hasConcept C2779448229 @default.
• W2921032705 hasConcept C2780434524 @default.
• W2921032705 hasConcept C55493867 @default.
• W2921032705 hasConcept C71924100 @default.
• W2921032705 hasConcept C89560881 @default.
• W2921032705 hasConcept C98274493 @default.
• W2921032705 hasConceptScore W2921032705C126322002 @default.
• W2921032705 hasConceptScore W2921032705C144594695 @default.
• W2921032705 hasConceptScore W2921032705C185592680 @default.
• W2921032705 hasConceptScore W2921032705C186738567 @default.
• W2921032705 hasConceptScore W2921032705C203014093 @default.
• W2921032705 hasConceptScore W2921032705C2776725428 @default.
• W2921032705 hasConceptScore W2921032705C2777292125 @default.
• W2921032705 hasConceptScore W2921032705C2778261982 @default.
• W2921032705 hasConceptScore W2921032705C2778382381 @default.
• W2921032705 hasConceptScore W2921032705C2778589496 @default.
• W2921032705 hasConceptScore W2921032705C2779448229 @default.
• W2921032705 hasConceptScore W2921032705C2780434524 @default.
• W2921032705 hasConceptScore W2921032705C55493867 @default.
• W2921032705 hasConceptScore W2921032705C71924100 @default.
• W2921032705 hasConceptScore W2921032705C89560881 @default.
• W2921032705 hasConceptScore W2921032705C98274493 @default.
• W2921032705 hasFunder F4320322025 @default.
• W2921032705 hasLocation W29210327051 @default.
• W2921032705 hasLocation W29210327052 @default.
• W2921032705 hasOpenAccess W2921032705 @default.
• W2921032705 hasPrimaryLocation W29210327051 @default.
• W2921032705 hasRelatedWork W1591132000 @default.
• W2921032705 hasRelatedWork W1965189182 @default.
• W2921032705 hasRelatedWork W2105662874 @default.
• W2921032705 hasRelatedWork W2121253457 @default.
• W2921032705 hasRelatedWork W2366308376 @default.
• W2921032705 hasRelatedWork W2367072416 @default.
• W2921032705 hasRelatedWork W2404763501 @default.
• W2921032705 hasRelatedWork W2421123155 @default.
• W2921032705 hasRelatedWork W2921032705 @default.
• W2921032705 hasRelatedWork W2921441540 @default.
• W2921032705 hasVolume "163" @default.
• W2921032705 isParatext "false" @default.
• W2921032705 isRetracted "false" @default.

• next