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- W2921034227 abstract "Introduction: H. Pylori is the most common chronic bacterial infection in humans. Although it is a causative factor for peptic ulcer disease, gastric adenocarcinoma and lymphoma, its role in esophageal adenocarcinoma is unclear. Methods: PubMed, Cochrane Library and clinicaltrail.gov databases and relevant conference proceedings were searched to identify articles from first available year to 2016 regarding the association of H. pylori and esophageal adenocarcinoma. All articles were evaluated by two separate authors. Articles lacking a comparable control group or reporting non-unique subjects, review articles and repeated studies were excluded. Data for odds ratio (OR) and 95% confidence interval (CI) was extracted and analyzed. A meta-analysis was conducted, and heterogeneity among studies was assessed through Cochran’s Q test and the I2 test. Results: Literature search initially generated 351 titles of which 21 articles were reviewed in full. A total of 14 studies including a total of 7,239 cases and 252,725 controls, based on the inclusion and exclusion criteria were analyzed in the meta-analysis. Four of the studies (figure 1) classified H.pylori status by histology and revealed a summary OR of 0.46 (95% CI 0.21, 1.01; p = 0.05), with considerable hetrogeneity (I2 = 92%). Ten studies classified H.pylori status by serology and had a summary OR of 0.60 (95% CI 0.48, 0.74; p < 0.0001), with low hetrogeneity (I2 = 28%). Conclusion: We found that in meta-analysis of observational studies, H. pylori infection is inversely associated with esophageal adenocarcinoma. The incidence of esophageal adenocarcinoma in the United States is increasing and might be linked to the declining rates of H. pylori.347_A Figure 1. Forest plot showing individual and summary odds ratio (95% CIs) for esophageal adenocarcinoma and Biopsy positive H.Pylori cases.347_B Figure 2. Forest Plot showing individual and summary odds ratio (95% CIs) for esophageal adenocarcinoma and serology positive H.Pylori cases." @default.
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- W2921034227 date "2018-10-01" @default.
- W2921034227 modified "2023-09-23" @default.
- W2921034227 title "Association of Helicobacter pylori Infection and Esophageal Adenocarcinoma: A Meta-Analysis" @default.
- W2921034227 doi "https://doi.org/10.14309/00000434-201810001-00347" @default.
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