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• W2921037800 abstract "BackgroundMycobacterium abscessus is an emerging pathogen in cystic fibrosis (CF) lung disease. Hospital transmission of M. abscessus has been described. This paper details the investigation into possible cross-transmission of M. abscessus locally at our paediatric hospital CF centre, and the subsequent infection control response.MethodsWhole genome sequencing (WGS) of M. abscessus respiratory isolates with epidemiological linkage analysis using hospital electronic medical records.Results6.7% (22/328) of CF patients had M. abscessus isolated from respiratory specimens.WGS revealed a cluster of three patients with genomically related isolates that differed by <7 single nucleotide polymorphisms (SNPs), suggesting a shared recent ancestor and probable cross-transmission.Epidemiological investigation revealed multiple potential crossovers between patients with genomically similar M. abscessus isolates.ConclusionsCross-infection of NTM occurs in CF hospital patients. Hospital infection control practices should be upgraded to reflect this. Consensus is needed between centres." @default.
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• W2921037800 date "2020-03-01" @default.
• W2921037800 modified "2023-10-03" @default.
• W2921037800 title "Investigating transmission of Mycobacterium abscessus amongst children in an Australian cystic fibrosis centre" @default.
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• W2921037800 doi "https://doi.org/10.1016/j.jcf.2019.02.011" @default.
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